Protein Alignment Ir85a and Grin2c

DIOPT Version :10

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: XP_017452477.1
• Gene: Grin2c / 24411
• RGDID: 2739
• Length: 1250
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 96/543 - (17%)
• Similarity: 201/543 - (37%)
• Gaps: 184/543 - (33%)

  Fly   159 WRDGRLNAYRYNPFMDNY---LIP-VDNKPNEVPTLEQLFPKTIPNMQRKPLRMCIYKDDVRAIF 219
            |..|.|  |...|....|   |.| ||::...|.|||:           :|..:....|.
  Rat   388 WDHGVL--YMKYPVWPRYSTSLQPVVDSRHLTVATLEE-----------RPFVIVESPDP----- 434

  Fly   220 WRQGTILGTDGLLAAYVAERLNATMMITRPHSYNNHNLS--SDIC----FLEVAKEYVDVAMNIR 278
                   ||.|.:...|..|..:.      |::::.:|:  :.:|    .:::.|:...|   ::
  Rat   435 -------GTGGCVPNTVPCRRQSN------HTFSSGDLTPYTKLCCKGFCIDILKKLAKV---VK 483

  Fly   279 F----------------------LVPDTFRKQAES-----TVSHTRDDLC-VIVPKAKTAPTFWN 315
            |                      ::.:.:.|:|:.     |::..|.::. ..||..:|..:..
  Rat   484 FSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVM- 547

  Fly   316 IFRSFGSL------------VWALILV---SVLVANVFCY-----------ILKSE--------V 346
            :.||.|::            ||.::.|   :|:...||.:           :.|.:        :
  Rat   548 VSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKPGGPSFTI 612

  Fly   347 GRVPMQLFAGAL--TMPMTQIPPNHSIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQL 409
            |:....|:|...  ::|: :.|...:.::.::.|.:|.::..:::..||.:.|:.:.|   |:.:
  Rat   613 GKSVWLLWALVFNNSVPI-ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQY---IDTV 673

  Fly   410 GALARSHYHIIIRPRHVKHIQHFLTLGHKHESRIREQMLEVSDTQMYEMMRNNDIRFAYLEKY-H 473
            ..|:...:.   ||:.......|.|:.:....|                    :||..|.:.: |
  Rat   674 SGLSDKKFQ---RPQDQYPPFRFGTVPNGSTER--------------------NIRSNYRDMHTH 715

  Fly   474 IARFQVNS----RVHMHLGRPLFHLMNSCLVPFHA-----VYIVPYGSPYL----GFLDSLIRSS 525
            :.:|...|    ...:.:|:....:.::.::.:.|     ..:|..||..:    |:..::.:.|
  Rat   716 MVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDS 780

  Fly   526 HEFGFERYWDRIMNSAFIK---------------SGVKVVNRRRGSGNDEPVV----LKLQHFHA 571
            |       |.|.::.|.::               ||:        ..|::..|    |.:.:...
  Rat   781 H-------WKRAIDLALLQLLGDGETQKLETVWLSGI--------CQNEKNEVMSSKLDIDNMAG 830

  Fly   572 VFALWLVGIGMACIVLAWEHLTH 594
            ||.:.||.:|:|.:|.|||||.:
  Rat   831 VFYMLLVAMGLALLVFAWEHLVY 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Grin2c	XP_017452477.1	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	4/10 (40%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	71/474 (15%)
		NMDAR2_C	850..>925	CDD:463148	2/4 (50%)