DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ir85a and Grin2b

DIOPT Version :10

Sequence 1:NP_649833.1 Gene:Ir85a / 41052 FlyBaseID:FBgn0037630 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_036706.1 Gene:Grin2b / 24410 RGDID:2738 Length:1482 Species:Rattus norvegicus


Alignment Length:586 Identity:110/586 - (18%)
Similarity:209/586 - (35%) Gaps:175/586 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 DGILMYMVMITTNISQPL-ELSLIRKKSAAKHRSH---VF---LLVRDADTVSDAWMRASFRQ-F 146
            |||    .:|||..|..| |.|.|.:..::.:.:|   ::   :|.|....|:......||.: .
  Rat   295 DGI----AIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDG 355

  Fly   147 WKIWLLNIVILY-----------WRDGRLN-AYRYNPFM--------DNYL--IPVDNKP----- 184
            :::....::||.           |:|..|. .|...|.|        |::|  :.::..|     
  Rat   356 YQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE 420

  Fly   185 -----------NEVPTLEQLFPKTIPNMQRKPLRMC-------IYKDDVRAIFWRQGTILGTDGL 231
                       |.||..:::..:...:.:...::.|       |.|...:::.:.....|.|:| 
  Rat   421 SVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNG- 484

  Fly   232 LAAYVAERLNATM--MITRPHSYNNHNLSSDICFLEVAKEYVDVAMNIRFLVP------DTFRKQ 288
               ...:::|.|.  ||........:.....:...|...|.||      |.||      .....:
  Rat   485 ---KHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVD------FSVPFIETGISVMVSR 540

  Fly   289 AESTVSHTRDDLCVIVPKAKTAPTFWNIFRSFGSLVWALILVSVLVAN---VFCYILKSEV---- 346
            :..|||          |.|...|        |.:.||.::.|.:|:.:   ||.:...|.|    
  Rat   541 SNGTVS----------PSAFLEP--------FSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNR 587

  Fly   347 ----GRVP----------MQLFAGAL---TMPMTQIPPNHSIRLFLIFWLYFGLLICSAFKGNLT 394
                ||.|          :.|..|.:   ::|: |.|...:.::.:..|.:|.::..:::..||.
  Rat   588 CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPV-QNPKGTTSKIMVSVWAFFAVIFLASYTANLA 651

  Fly   395 SMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGH-KHESRIREQMLEVSDTQMYEM 458
            :.|:.:.|   ::|:..|:...:.   ||........|.|:.: ..|..||....|:        
  Rat   652 AFMIQEEY---VDQVSGLSDKKFQ---RPNDFSPPFRFGTVPNGSTERNIRNNYAEM-------- 702

  Fly   459 MRNNDIRFAYLEKYHIARFQVNSRVHMHLGRPLFHLMNSCLVPFHA-----VYIVPYGSPYLGFL 518
                   .||:.|:: .|...::.:.:..|:....:.::.::.:.|     ..:|..||      
  Rat   703 -------HAYMGKFN-QRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGS------ 753

  Fly   519 DSLIRSSHEFGF----ERYWDRIMNSAFIKSGVKVVNRRRGSGNDEPVVLKLQHFHAVFALWLVG 579
             ..:.:|..:|.    :..|.|.::.|.:        :..|.|..|.:.          ||||.|
  Rat   754 -GKVFASTGYGIAIQKDSGWKRQVDLAIL--------QLFGDGEMEELE----------ALWLTG 799

  Fly   580 I 580
            |
  Rat   800 I 800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir85aNP_649833.1 None
Grin2bNP_036706.1 PBP1_iGluR_NMDA_NR2 33..388 CDD:380601 22/96 (23%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 85/474 (18%)
Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489 604..623 4/19 (21%)
NMDAR2_C 840..1482 CDD:463148
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1194
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1269..1301
Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097 1292..1304
PDZ-binding 1480..1482
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.