Protein Alignment Ir85a and Grin3a

DIOPT Version :10

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 917
• Identity: 174/917 - (18%)
• Similarity: 289/917 - (31%)
• Gaps: 285/917 - (31%)

  Fly    61 KDRQKNKAKQSFLLR----NYIGFEKSFPLKNKNQTLTVIT---------KDHNVVLAFQLPETL 112
            |:||:::.:.:.|..    |.:.:::||   .::..|.::.         |..|.......||.
Mouse    43 KERQESRKEVAVLANMSHPNIVQYKESF---EESGCLYIVMDYCEGGDLFKKINNQRGSLFPEE- 103

  Fly   113 LQWETWF-------KNVGGQSTTHYMQLLKFPNQQDNVSFINKEVRCHLHDSRLAIVHGYPAETL 170
             |...||       |:|      |..::|....:..|: |:.|:....|.|..:|.|.....|..
Mouse   104 -QILDWFVQICLALKHV------HDRKILHRDIKSQNI-FLTKDGTVQLGDFGIARVLNSTVELA 160

  Fly   171 LYCEVAGASITTDHMNHRVTITP--------NDGSSEFLFCCPSIEMFSRLLKKANEDDGSLNLY 227
            ..|      |.|.:.     ::|        |:.|..:...|...||.:  ||.|.|.....||.
Mouse   161 RTC------IGTPYY-----LSPEICENKPYNNKSDIWALGCVLYEMCT--LKHAFEAGNMKNLV 212

  Fly   228 LNKKHAEGVWLQNIGNRTRKHQDSISGLSGTFSGWFNPMKPTTPSINQSEIFSSRAAINTLGIRN 292
            |.                            ...|.:.|:     ||:.|.  ..|:.:..|..||
Mouse   213 LK----------------------------IIRGSYPPV-----SIHYSP--DLRSLLAQLFKRN 242

  Fly   293 PGSKTPVGSL-----------KFLNGLLPDLILS--------SPPVITAAETPVVYP-------- 330
            |..:..|.::           |||:   |.||..        .|.:..|...|...|
Mouse   243 PRERPSVSTILDKPFLARRIHKFLS---PQLIAQEFSHSIHLQPKMSVAHAAPAKRPAPGPIPIT 304

  Fly   331 -SQQITSTSESPVLSTTDNSPYLGSEAKQRSTSLPEYVNVSHVIRPTPPLPE---------EPSR 385
             :|:||..:....:..|...|   ||..::   :|:.......::..|| |.         |..|
Mouse   305 SAQKITKPAAKYGVPLTVRRP---SEVARK---VPDAAKKPVKLKQAPP-PAAVQRRVSRVEEER 362

  Fly   386 TNHHEVIHRKASTM---TTPARESPRFSNCGEHKDFMPNRIPSKGRSMMDFSTLPYEDSGSRYES 447
            ..|.|.:.:|...|   ....||........:.|.|...::....|              :|.:.
Mouse   363 RKHEEGVRKKRMEMMERERKQREQMLLLKAAQMKRFEREKLNRINR--------------AREQG 413

  Fly   448 WRRAKKFISAFSQKSHQDLYKSAPKIGKRKASSTSALTYRTHESKHSFALSTSSSSEVDELPPPA 512
            ||..  ..|:......:..|......|...:...|...........|.||: .|.:..|.:.|.|
Mouse   414 WRHV--LSSSGGSSPERKFYGGGGGNGAPHSPGISPFPVPGPSPVPSSALA-PSRAPYDRIHPSA 475

  Fly   513 LNVAVTNPAPPLIPRKDKSNEPEIIPAGLVRLREEGSLKMRGGV-----------NIALARRLAA 566
              ..:|.|.|     ||.:.|      |.|...:.|......|.           .:...:|..:
Mouse   476 --EKLTKPTP-----KDGAGE------GAVHAGDNGRTSSDSGTLNGHACIPVKNGVRKEQRKTS 527

  Fly   567 GINGSFTKYD---GDRGTHVYPQTPEEKERKIEEFIEERRRTASTRKV--ESPDFSNDVLGKVVS 626
            ..|...:|.|   ..||     |...||.:::|||: :|:|.|...||  |....:...|..:.:
Mouse   528 LQNEQISKIDYANRFRG-----QLAVEKSKQVEEFL-QRKREAMLNKVRAEGQLGARQNLAAIFA 586

  Fly   627 NETEKFRLMERRASSVS---FNKANAVQISLLNENQK-KAAALITNHNRENSQSESMASSS---- 683
            :.|...|....|.:...   ..:...:::...||.|: ||......::.:.|.|:.....:
Mouse   587 SWTNSSRCRRPRVNKEEEEYLTRLRQIRLQNFNERQQIKARLRGEKYDSDGSDSQESCEEAVLRM 651

  Fly   684 ---ESLSSDARSKISI------KKRSNSPPR------------------------TVAPCILPKQ 715
               |:|.:.::::.::      |||..:..|                        |.:|...|..
Mouse   652 KKIEALKAQSKARAAVLKEQLEKKRREAYEREKKAWEDHQLVARGVKVAVGPVGGTPSPAAPPTP 716

  Fly   716 PSQRTLTLQQQSSSSIDSLNSTQTTRTTSSVRLPTRILVNQSSTSSEGSSGKSQHYFESKVGPKT 780
            ||..| ..:..|.::..|..||.....|::::                           .||..:
Mouse   717 PSDPT-PQEAPSKATPSSRPSTPAISMTAALK---------------------------DVGAIS 753

  Fly   781 SSTSHPSDSSHYILGRQDSRRMSEGQGSNSSDAMAQARKGYFRKNNK------------TRRSNR 833
            |..|.|.        ::||.::      .|||..:..::...|.|.|            |..||:
Mouse   754 SGQSSPM--------KEDSLKV------ESSDVQSDKKEILRRLNQKVQTTEEVSVKEPTPSSNQ 804

  Fly   834 HLDDTSP 840
            ...|..|
Mouse   805 PCPDPQP 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	108/552 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118		11/63 (17%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	64/348 (18%)
		Lig_chan	674..941	CDD:459656	33/180 (18%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115