Protein Alignment Ir85a and Grin2b

DIOPT Version :10

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_032197.3
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 586
• Identity: 110/586 - (18%)
• Similarity: 209/586 - (35%)
• Gaps: 175/586 - (29%)

  Fly    90 DGILMYMVMITTNISQPL-ELSLIRKKSAAKHRSH---VF---LLVRDADTVSDAWMRASFRQ-F 146
            |||    .:|||..|..| |.|.|.:..::.:.:|   ::   :|.|....|:......||.: .
Mouse   295 DGI----AIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDG 355

  Fly   147 WKIWLLNIVILY-----------WRDGRLN-AYRYNPFM--------DNYL--IPVDNKP----- 184
            :::....::||.           |:|..|. .|...|.|        |::|  :.::..|
Mouse   356 YQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE 420

  Fly   185 -----------NEVPTLEQLFPKTIPNMQRKPLRMC-------IYKDDVRAIFWRQGTILGTDGL 231
                       |.||..:::..:...:.:...::.|       |.|...:::.:.....|.|:|
Mouse   421 SVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNG- 484

  Fly   232 LAAYVAERLNATM--MITRPHSYNNHNLSSDICFLEVAKEYVDVAMNIRFLVP------DTFRKQ 288
               ...:::|.|.  ||........:.....:...|...|.||      |.||      .....:
Mouse   485 ---KHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVD------FSVPFIETGISVMVSR 540

  Fly   289 AESTVSHTRDDLCVIVPKAKTAPTFWNIFRSFGSLVWALILVSVLVAN---VFCYILKSEV---- 346
            :..|||          |.|...|        |.:.||.::.|.:|:.:   ||.:...|.|
Mouse   541 SNGTVS----------PSAFLEP--------FSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNR 587

  Fly   347 ----GRVP----------MQLFAGAL---TMPMTQIPPNHSIRLFLIFWLYFGLLICSAFKGNLT 394
                ||.|          :.|..|.:   ::|: |.|...:.::.:..|.:|.::..:::..||.
Mouse   588 CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPV-QNPKGTTSKIMVSVWAFFAVIFLASYTANLA 651

  Fly   395 SMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGH-KHESRIREQMLEVSDTQMYEM 458
            :.|:.:.|   ::|:..|:...:.   ||........|.|:.: ..|..||....|:
Mouse   652 AFMIQEEY---VDQVSGLSDKKFQ---RPNDFSPPFRFGTVPNGSTERNIRNNYAEM-------- 702

  Fly   459 MRNNDIRFAYLEKYHIARFQVNSRVHMHLGRPLFHLMNSCLVPFHA-----VYIVPYGSPYLGFL 518
                   .||:.|:: .|...::.:.:..|:....:.::.::.:.|     ..:|..||
Mouse   703 -------HAYMGKFN-QRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGS------ 753

  Fly   519 DSLIRSSHEFGF----ERYWDRIMNSAFIKSGVKVVNRRRGSGNDEPVVLKLQHFHAVFALWLVG 579
             ..:.:|..:|.    :..|.|.::.|.:        :..|.|..|.:.          ||||.|
Mouse   754 -GKVFASTGYGIAIQKDSGWKRQVDLAIL--------QLFGDGEMEELE----------ALWLTG 799

  Fly   580 I 580
            |
Mouse   800 I 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Grin2b	NP_032197.3	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	22/96 (23%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	85/474 (18%)
		NMDAR2_C	840..1482	CDD:463148