Protein Alignment Ir85a and Grin2a

DIOPT Version :10

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 732
• Identity: 142/732 - (19%)
• Similarity: 250/732 - (34%)
• Gaps: 254/732 - (34%)

  Fly    23 ENHIPLD-----------LKK--SSIVMVKMSQ-----ILCKARIKVL----FVYFENQTSHEHT 65
            :|.|.||           |||  ||::::..|:     ||.:||...|    |.:........:|
Mouse   201 QNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNT 265

  Fly    66 GQILKEVTKCDIS----NQNTPLEAVKDDGILMYMVMITTNISQPLE-LSLI-----------RK 114
            ..|.||.....||    :.:..|||...||    :.::||..|..|| .|.|           .|
Mouse   266 ELIPKEFPSGLISVSYDDWDYSLEARVRDG----LGILTTAASSMLEKFSYIPEAKASCYGQTEK 326

  Fly   115 KSAAKHRSHVFLLVRDADTVSDAW--MRASF-RQFWKIWLLNIVILY-----------WRDGRLN 165
            .....|..|.|:       |:..|  ...|| .:.:::....:||:.           |.:..|:
Mouse   327 PETPLHTLHQFM-------VNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQTLS 384

  Fly   166 AY-----RYNPFM-----DNYL--IPVDNKPNEV-----PTLEQLFPKTIP-------------- 199
            ..     ||..|.     ||:|  :.::..|..:     |..|.....|:|
Mouse   385 LRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEG 449

  Fly   200 -NMQRKPLRMC--IYKDDVRAIFWRQGTILGT------------DGLLAAYVAERLNATMMITRP 249
             |:::.....|  |.|...|.:.:.....|.|            :|::...|.:|  |.|.:
Mouse   450 MNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQR--AVMAV--- 509

  Fly   250 HSYNNHNLSSDICFLEVAKEYVDVAMNIRFLVP------DTFRKQAESTVSHTRDDLCVIVPKAK 308
                     ..:...|...|.||      |.||      .....::..|||          |.|.
Mouse   510 ---------GSLTINEERSEVVD------FSVPFVETGISVMVSRSNGTVS----------PSAF 549

  Fly   309 TAPTFWNIFRSFGSLVWALILVSVLVAN---VFCYILKSEV--------GRVP----------MQ 352
            ..|        |.:.||.::.|.:|:.:   ||.:...|.|        |:.|          :.
Mouse   550 LEP--------FSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIW 606

  Fly   353 LFAGAL---TMPMTQIPPNHSIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALAR 414
            |..|.:   ::|: |.|...:.::.:..|.:|.::..:::..||.:.|:.:.:   ::|:..|:.
Mouse   607 LLWGLVFNNSVPV-QNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEF---VDQVTGLSD 667

  Fly   415 SHYHIIIRPRHVKHIQHFLTLGHKHESRIREQMLEVSDTQMYEMMRNNDIRFAYLEKYHIARFQV 479
            ..:.   ||             |.:....|...:....|:  ..:|||   :.|:.:| :.:|
Mouse   668 KKFQ---RP-------------HDYSPPFRFGTVPNGSTE--RNIRNN---YPYMHQY-MTKF-- 708

  Fly   480 NSR------VHMHLGRPLFHLMNSCLVPFHA-----VYIVPYGSPYL----GFLDSLIRSSHEFG 529
            |.|      |.:..|:....:.::.::.:.|     ..:|..||.|:    |:..:|.:.|.
Mouse   709 NQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSP--- 770

  Fly   530 FERYWDRIMNSAFIKSGVKVVNRRRGSGNDEPV-------------------VLKLQHFHAVFAL 575
                |.|.::.|.::.        .|.|..|.:                   .|.:.:...||.:
Mouse   771 ----WKRQIDLALLQF--------VGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYM 823

  Fly   576 WLVGIGMACIVLAWEHL 592
            ....:.::.|...||||
Mouse   824 LAAAMALSLITFIWEHL 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	46/196 (23%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	85/479 (18%)
		NMDAR2_C	839..1464	CDD:463148	2/2 (100%)