Protein Alignment Mkk4 and MKK1

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_014874.1
• Gene: MKK1 / 854406
• SGDID: S000005757
• Length: 508
• Species: Saccharomyces cerevisiae
• Alignment Length: 373
• Identity: 134/373 - (35%)
• Similarity: 195/373 - (52%)
• Gaps: 39/373 - (10%)

  Fly    33 PPSSTSSTSSGSTSS----GSSSSSQHNHVTRCFGAQQPQQTPPVASSQVPPVPAASSSSAADRH 93
            |.|..|..|..:|||    ...|:|..:..:....|.:...:|..:|||    |.:||.|..|.:
Yeast   139 PSSMASPFSHTNTSSPYLRNDLSNSVGSDFSNLISAYEQSSSPIKSSSQ----PKSSSESYIDLN 199

  Fly    94 RERIRQQACGKLQFGEGG---ANTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRS 155
            ..|...      |..|.|   ||    ..|.:|..|.:|.||.|:|:|...|...|:.|:|.|.:
Yeast   200 SVRDVD------QLDENGWKYAN----LKDRIETLGILGEGAGGSVSKCKLKNGSKIFALKVINT 254

  Fly   156 -TVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGD---CWICMELM-DTSLDKFYKYIYEK 215
             ..|.:.|||:..:|: ..:|.:..|||::|| :|.:.:   .:|.||.| ..|||..||.:.|:
Yeast   255 LNTDPEYQKQIFRELQ-FNRSFQSEYIVRYYG-MFTDDENSSIYIAMEYMGGRSLDAIYKNLLER 317

  Fly   216 QQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAK 280
            ..| |.|.:|.||..|.:..|:||.|: |:||||:||.||||:..|.:||||||:||:.|:|:|
Yeast   318 GGR-ISEKVLGKIAEAVLRGLSYLHEK-KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLA- 379

  Fly   281 TKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPYRKWD-----SVFEQLCQVV 340
            |...|...|||||||   :.:.|.|.|||||||:|::|||.|.||.....     :.||.|..::
Yeast   380 TTFTGTSFYMAPERI---QGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWIL 441

  Fly   341 QGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIR 388
            ...|.......:.:.:|..|..|::.||.|...:||...:::..|:|:
Yeast   442 TFTPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWIK 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	109/284 (38%)
MKK1	NP_014874.1	Protein Kinases, catalytic domain	219..506	CDD:473864	109/279 (39%)