DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mkk4 and Stk39

DIOPT Version :10

Sequence 1:NP_477353.1 Gene:Mkk4 / 41020 FlyBaseID:FBgn0024326 Length:424 Species:Drosophila melanogaster
Sequence 2:NP_062235.1 Gene:Stk39 / 54348 RGDID:621643 Length:553 Species:Rattus norvegicus


Alignment Length:359 Identity:104/359 - (28%)
Similarity:166/359 - (46%) Gaps:52/359 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 QQPQQTPPV--------------ASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTH 115
            |.|||..||              |.:..|..|||.:.:.|.........||.|           .
  Rat    12 QLPQQAAPVTAAAAAPAAATSAPAPAPAPAAPAAPAPAPAAAPAPAPAAQAVG-----------W 65

  Fly   116 TFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIY 180
            ....|..|.:..||.||...|.....|...:.:|:|||.....:....:||.:::.:   ::|.:
  Rat    66 PICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAM---SQCSH 127

  Fly   181 --IVQFYGALFKEGDCWICMELMD--TSLDKFYKYIYEKQQRH---IPESILAKITVATVNALNY 238
              :|.:|.:...:.:.|:.|:|:.  :.|| ..|||..:.:..   :.|:|:|.|....:..|:|
  Rat   128 PNVVTYYTSFVVKDELWLVMKLLSGGSMLD-IIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDY 191

  Fly   239 LKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLV-------DSIAKTKDAGCRPYMAPERID 296
            |....: ||||:|..||||...|.:::.|||:|..|.       :.:.|| ..|...:||||.: 
  Rat   192 LHRNGQ-IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKT-FVGTPCWMAPEVM- 253

  Fly   297 PERAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGME----FS 357
             |:.:|||.::|:||.|||.:|:|||..||.|:..: :.|...:|.:||.|.|.....|    :.
  Rat   254 -EQVRGYDFKADMWSFGITAIELATGAAPYHKYPPM-KVLMLTLQNDPPTLETGVEDKEMMKKYG 316

  Fly   358 KEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGE 391
            |.|...::.||.|..|.||..:.||:..|.::.:
  Rat   317 KSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mkk4NP_477353.1 PKc_MKK4 115..405 CDD:270790 89/295 (30%)
Stk39NP_062235.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..55 12/42 (29%)
STKc_OSR1_SPAK 70..346 CDD:270787 88/284 (31%)
Interaction with RELT. /evidence=ECO:0000250|UniProtKB:Q9Z1W9 319..544 10/32 (31%)
Nuclear localization signal. /evidence=ECO:0000255 369..375
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..431
Caspase cleavage related site 396..400
OSR1_C 460..517 CDD:463491
Blue background indicates that the domain is not in the aligned region.

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