Protein Alignment Mkk4 and map2k6

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_001005653.1
• Gene: map2k6 / 448132
• XenbaseID: XB-GENE-944183
• Length: 335
• Species: Xenopus tropicalis
• Alignment Length: 346
• Identity: 173/346 - (50%)
• Similarity: 227/346 - (65%)
• Gaps: 27/346 - (7%)

  Fly    63 GAQQPQQT--PPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDE 125
            |.:.|::.  .|..||..||              ..:..:||  :..||   ......:||||..
 Frog    12 GLKIPKEAFDQPQVSSPTPP--------------RDLDSKAC--ILIGE---KNFEVKADDLEPI 57

  Fly   126 GEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFK 190
            .|:||||:|.|.||.....:::|||||||:||:.:|||:|||||::.|::.:|.:.|.||||||:
 Frog    58 EELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFR 122

  Fly   191 EGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNI 255
            |||.||||||||||||||||.:.:|... |||.||.||.|:.|.||.:|..:|.:|||||||||:
 Frog   123 EGDVWICMELMDTSLDKFYKNVIDKGLT-IPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNV 186

  Fly   256 LLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPE-RAKGYDVRSDVWSLGITLMEV 319
            |:::.|.:|:|||||||.||||:|||.||||:||||||||:|| ..|||.|:||:|||||||:|:
 Frog   187 LINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIEL 251

  Fly   320 ATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEM 384
            |...|||..|.:.|:||.|||:...|:|...    :||.|||||.:.||.|...:||.|..|::.
 Frog   252 AILRFPYDSWGTPFQQLKQVVEEPSPQLPAD----KFSAEFVDFTSKCLKKNSKERPTYPELMQH 312

  Fly   385 PFIRRGETSHTDVAVYVADIL 405
            .|....|:.:||||.:|..||
 Frog   313 HFFVLHESKNTDVASFVKRIL 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	160/290 (55%)
map2k6	NP_001005653.1	PKc_MKK3_6	52..334	CDD:173729	162/287 (56%)