Protein Alignment Mkk4 and Map2k4

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: XP_063124696.1
• Gene: Map2k4 / 287398
• RGDID: 1307040
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 390
• Identity: 228/390 - (58%)
• Similarity: 276/390 - (70%)
• Gaps: 18/390 - (4%)

  Fly    28 LSIRHPPSSTSSTSSGSTSSGSSSSSQHNHVTRCFGAQQPQQTPPVASSQ----VPPVPAASSSS 88
            |:..:||..:::.   .|.:.:::..|:.|:.|..  :....|.....||    |...||.....
  Rat    55 LNFANPPVKSTAR---FTLNPNTTGVQNPHMHRLL--KSNSDTMKYILSQHWSCVTETPAPVRQR 114

  Fly    89 AADRHRERIRQ---QACGKLQFGEGGANTH-TFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMA 149
            .....:||:|.   ::.|||:.   ....| .||::||:|.|||||||:|:||||..|...::||
  Rat   115 QEFETKERLRTHSIESSGKLKI---SPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMA 176

  Fly   150 VKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYE 214
            ||||||||||||||||||||:|||:|::|.||||||||||:|||||||||||.||.||||||:|.
  Rat   177 VKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYS 241

  Fly   215 KQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIA 279
            .....|||.||.|||:|||.|||:|||.|||||||:|||||||.|.|:|||||||||||||||||
  Rat   242 VLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIA 306

  Fly   280 KTKDAGCRPYMAPERIDPERAK-GYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGE 343
            ||:|||||||||||||||..:: |||||||||||||||.|:|||.|||.||:|||:||.|||:|:
  Rat   307 KTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGD 371

  Fly   344 PPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVADILESM 408
            ||:|..| ...|||..|::|||.||.|.||.||||..||:.|||...|....:||.||..||:.|
  Rat   372 PPQLSNS-EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQM 435

  Fly   409  408
              Rat   436  435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	206/291 (71%)
Map2k4	XP_063124696.1	None