Protein Alignment Mkk4 and STK39

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_037365.2
• Gene: STK39 / 27347
• HGNCID: 17717
• Length: 545
• Species: Homo sapiens
• Alignment Length: 353
• Identity: 105/353 - (29%)
• Similarity: 166/353 - (47%)
• Gaps: 49/353 - (13%)

  Fly    65 QQPQQTPPV--------ASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDD 121
            |.|||..||        |::...|.|||   .||.........||.|           .....|.
Human    12 QLPQQAAPVTAAAAAAPAAATAAPAPAA---PAAPAPAPAPAAQAVG-----------WPICRDA 62

  Fly   122 LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIY--IVQF 184
            .|.:..||.||...|.....|...:.:|:|||.....:....:||.:::.:   ::|.:  :|.:
Human    63 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAM---SQCSHPNVVTY 124

  Fly   185 YGALFKEGDCWICMELMD--TSLDKFYKYIYEKQQRH---IPESILAKITVATVNALNYLKEELK 244
            |.:...:.:.|:.|:|:.  :.|| ..|||..:.:..   :.|:|:|.|....:..|:||....:
Human   125 YTSFVVKDELWLVMKLLSGGSMLD-IIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQ 188

  Fly   245 IIHRDVKPSNILLHRRGDIKLCDFGISGQLV-------DSIAKTKDAGCRPYMAPERIDPERAKG 302
             ||||:|..||||...|.:::.|||:|..|.       :.:.|| ..|...:||||.:  |:.:|
Human   189 -IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKT-FVGTPCWMAPEVM--EQVRG 249

  Fly   303 YDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGME----FSKEFVDF 363
            ||.::|:||.|||.:|:|||..||.|:..: :.|...:|.:||.|.|.....|    :.|.|...
Human   250 YDFKADMWSFGITAIELATGAAPYHKYPPM-KVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKL 313

  Fly   364 VNTCLIKKESDRPKYSRLLEMPFIRRGE 391
            ::.||.|..|.||..:.||:..|.::.:
Human   314 LSLCLQKDPSKRPTAAELLKCKFFQKAK 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	89/295 (30%)
STK39	NP_037365.2	STKc_OSR1_SPAK	61..337	CDD:270787	88/284 (31%)
		Interaction with RELT. /evidence=ECO:0000250|UniProtKB:Q9Z1W9	310..536		10/32 (31%)
		Nuclear localization signal. /evidence=ECO:0000255	360..366
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..423
		Caspase cleavage related site	387..391
		OSR1_C	452..509	CDD:463491