Protein Alignment Mkk4 and Map2k6

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: XP_036012601.1
• Gene: Map2k6 / 26399
• MGIID: 1346870
• Length: 347
• Species: Mus musculus
• Alignment Length: 342
• Identity: 171/342 - (50%)
• Similarity: 222/342 - (64%)
• Gaps: 31/342 - (9%)

  Fly    65 QQPQQTPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIG 129
            :|||      :|..||              ..:..:||..:     |.......:||||...|:|
Mouse    34 EQPQ------TSSTPP--------------RDLDSKACISI-----GNQNFEVKADDLEPIVELG 73

  Fly   130 RGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDC 194
            |||:|.|.||......::|||||||:||:.:|||:|||||:|.|::.:|.:.|.||||||:|||.
Mouse    74 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDV 138

  Fly   195 WICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHR 259
            ||||||||||||||||.:.:|.|. |||.||.||.|:.|.||.:|..:|.:|||||||||:|::.
Mouse   139 WICMELMDTSLDKFYKQVIDKGQT-IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINT 202

  Fly   260 RGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPE-RAKGYDVRSDVWSLGITLMEVATGN 323
            .|.:|:|||||||.||||:|||.||||:||||||||:|| ..|||.|:||:||||||::|:|...
Mouse   203 LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR 267

  Fly   324 FPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIR 388
            |||..|.:.|:||.|||:...|:|...    :||.:||||.:.||.|...:||.|..|::.||..
Mouse   268 FPYDSWGTPFQQLKQVVEEPSPQLPAD----KFSADFVDFTSQCLKKNSKERPTYPELMQHPFFT 328

  Fly   389 RGETSHTDVAVYVADIL 405
            ..|:...|||.:|..||
Mouse   329 VHESKAADVASFVKLIL 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	160/290 (55%)
Map2k6	XP_036012601.1	PKc_MKK3_6	64..346	CDD:173729	162/287 (56%)