Protein Alignment Mkk4 and Map2k3

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_032954.1
• Gene: Map2k3 / 26397
• MGIID: 1346868
• Length: 347
• Species: Mus musculus
• Alignment Length: 376
• Identity: 176/376 - (46%)
• Similarity: 237/376 - (63%)
• Gaps: 43/376 - (11%)

  Fly    33 PPSSTSSTSSGSTSSGSSSSSQHNHVTRCFGAQQPQQTPPVASSQVPP--VPAASSSSAADRHRE 95
            ||:|...|      .|.|...:...:: |.      ..||| |:..||  :.:.:..:..||:.|
Mouse     8 PPASLPQT------KGKSKRKKDLRIS-CV------SKPPV-SNPTPPRNLDSRTFITIGDRNFE 58

  Fly    96 RIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEK 160
                                 ..:|||....|:||||:|.|.|:...:...:|||||||:||:.:
Mouse    59 ---------------------VEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQ 102

  Fly   161 EQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESIL 225
            |||:|||||::.|::.:|.|.|.||||||:|||.|||||||||||||||:.:.||..: |||.||
Mouse   103 EQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMK-IPEDIL 166

  Fly   226 AKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYM 290
            .:|.|:.|.||.:|..:|.:|||||||||:|:::.|.:|:|||||||.||||:|||.||||:|||
Mouse   167 GEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYM 231

  Fly   291 APERIDPE-RAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGM 354
            |||||:|| ..|||:|:|||||||||::|:|...|||..|.:.|:||.|||:...|:|...
Mouse   232 APERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD---- 292

  Fly   355 EFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVADIL 405
            :||.|||||.:.||.|..::|..|..|:|.||....:|..||:|.:|.:||
Mouse   293 QFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEIL 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	158/290 (54%)
Map2k3	NP_032954.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		13/50 (26%)
		PKc_MKK3_6	62..344	CDD:173729	160/287 (56%)