DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mkk4 and Map2k5

DIOPT Version :10

Sequence 1:NP_477353.1 Gene:Mkk4 / 41020 FlyBaseID:FBgn0024326 Length:424 Species:Drosophila melanogaster
Sequence 2:NP_035970.1 Gene:Map2k5 / 23938 MGIID:1346345 Length:448 Species:Mus musculus


Alignment Length:410 Identity:145/410 - (35%)
Similarity:202/410 - (49%) Gaps:79/410 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 PKNLFATGSSRSRNPPDQLSLNNLSIRHPPSSTSSTSSGSTSSGSSSSSQHNHVTRCFGAQQPQQ 69
            |..:|    .|:..||.:.:::.|.:             :|.:|.|                 |.
Mouse   101 PLQIF----PRACKPPGERNIHGLKV-------------NTRAGPS-----------------QH 131

  Fly    70 TPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFG 134
            |.||.|..:|      |:|......|..:..|.|::            ...|:.....:|.|..|
Mouse   132 TSPVVSDSLP------SNSLKKSSAELRKILANGQM------------NEQDIRYRDTLGHGNGG 178

  Fly   135 AVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICME 199
            .|.|.......|::|||.|...:..:.|||::.:||::.|.:.. ||:.||||.|.|....||.|
Mouse   179 TVYKAHHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSS-YIIGFYGAFFVENRISICTE 242

  Fly   200 LMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDI 263
            .|| .|||     :|.|    |||.:|.:|.||.|..|.|| ..|||:||||||||:|::..|.:
Mouse   243 FMDGGSLD-----VYRK----IPEHVLGRIAVAVVKGLTYL-WSLKILHRDVKPSNMLVNTGGQV 297

  Fly   264 KLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPY-- 326
            ||||||:|.|||:|||||. .|...|||||||..|:   |.:.||||||||:.||:|.|.|||  
Mouse   298 KLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISGEQ---YGIHSDVWSLGISFMELALGRFPYPQ 358

  Fly   327 --RKWDSVFE-QLCQ-VVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI 387
              :...|:.. ||.| :|..:.|.|...    |||:.||.|:..|:.|:..:||....|:..|||
Mouse   359 IQKNQGSLMPLQLLQCIVDEDSPVLPLG----EFSEPFVHFITQCMRKQPKERPAPEELMGHPFI 419

  Fly   388 -RRGETSHTDVAVYVADILE 406
             :..:.:.|.|:::|...||
Mouse   420 VQFNDGNSTVVSMWVCRALE 439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mkk4NP_477353.1 PKc_MKK4 115..405 CDD:270790 123/297 (41%)
Map2k5NP_035970.1 PB1_Map2k5 17..107 CDD:99717 2/9 (22%)
Interaction with MAPK7. /evidence=ECO:0000269|PubMed:16507987 18..25
Interaction with MAP3K2/MAP3K3. /evidence=ECO:0000269|PubMed:12813044, ECO:0000269|PubMed:16507987 64..68
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..144 11/63 (17%)
Interaction with MAPK7. /evidence=ECO:0000269|PubMed:16507987 117..131 4/43 (9%)
PKc_MKK5 164..442 CDD:132950 125/295 (42%)
Blue background indicates that the domain is not in the aligned region.

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