Protein Alignment Mkk4 and sek-5

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_508916.3
• Gene: sek-5 / 185267
• WormBaseID: WBGene00018034
• Length: 360
• Species: Caenorhabditis elegans
• Alignment Length: 363
• Identity: 116/363 - (31%)
• Similarity: 173/363 - (47%)
• Gaps: 50/363 - (13%)

  Fly    64 AQQPQQTPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTS-------DD 121
            :|.|.:..|.....:||:            ||.|.:..       :.||..:...|       ::
 Worm     2 SQPPGRRMPRPKLDLPPL------------RETIPEVL-------KNGALGYICVSGRILSVPEN 47

  Fly   122 LEDEGE-IGRG-AFGAVNKMTFKKLDKVMAVK----RIRSTVDEKEQKQL----LMDLEVVMKSN 176
            |...|| ||.| ...||.::.:.  .|::|.|    |:...||:....:|    |.::.|:....
 Worm    48 LLYGGERIGNGEGQSAVYRLIYN--GKLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVINGCA 110

  Fly   177 ECIYIVQFYG-ALFKEGDC---WICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALN 237
            .|.:||.|:| .:.|..||   .|.||.|..|. ...|....||...|||.::.:|..:.::|:.
 Worm   111 PCPFIVHFFGYYVHKYRDCVKIHIFMEEMALSA-SVLKTEALKQGGAIPEFVIGRIVCSVIHAMW 174

  Fly   238 YLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERI--DPERA 300
            :||:.|:|||||:||.|||:...|.:|:|||||.|.|.:||| ..|.||:.|.|||.:  ....:
 Worm   175 FLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENSIA-VSDTGCQQYTAPEILVKGVSNS 238

  Fly   301 KGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVN 365
            .||.::||:||||||:.|:||..:||....|.|..|..:|....|.|...    .:|...|:||:
 Worm   239 PGYSIKSDIWSLGITIFELATLRYPYPVGFSEFTLLSAIVTTPAPYLERG----TYSDSLVEFVS 299

  Fly   366 TCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVAD 403
            ..|..||:|||....:.::.|....:|....:...|.|
 Worm   300 KLLQIKEADRPSIVAVKDLQFFLNNDTPFLCIGTGVGD 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	106/312 (34%)
sek-5	NP_508916.3	Protein Kinases, catalytic domain	58..311	CDD:473864	95/260 (37%)