Protein Alignment Mkk4 and sek-4

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_508915.3
• Gene: sek-4 / 180811
• WormBaseID: WBGene00018035
• Length: 364
• Species: Caenorhabditis elegans
• Alignment Length: 359
• Identity: 111/359 - (30%)
• Similarity: 171/359 - (47%)
• Gaps: 43/359 - (11%)

  Fly    62 FGAQ--QPQQTPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLED 124
            ||.:  :|:...|.....:|.|               ::..|.|.:..  .|.|.:. ..|.|..
 Worm     4 FGRRVPRPKLDLPALRETIPEV---------------LKNGALGYICL--SGRNLNV-PEDMLHG 50

  Fly   125 EGEIGRG-AFGAVNKMTFKKLDKVMAVK----RIRSTVDEKEQKQL----LMDLEVVMKSNECIY 180
            ...||.| ...||.::.:..:  |:|.|    |:....||....:|    |.::.|:.....|.:
 Worm    51 GVRIGSGEGQSAVYRLIYNGM--VIARKDVAVRLPQGGDEDSTNKLMAKRLREVNVINGCAPCPF 113

  Fly   181 IVQFYG-ALFKEGDC---WICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKE 241
            ||.|:| .:.|..||   .|.||.|..|.....|.:. |:...:||.::.:|..:.::|:.:|||
 Worm   114 IVHFFGYYVHKYKDCVKIHIFMEEMALSASVLKKEVL-KRGGIVPEFVIGRIACSVIHAMWFLKE 177

  Fly   242 ELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPE--RIDPERAKGYD 304
            :::|||||:||.|||:...|.:|:|||||||.|.|||| ....||:.|.|||  .:....:.||.
 Worm   178 KMQIIHRDIKPGNILIDYDGRVKICDFGISGILQDSIA-VSATGCQQYTAPEINELAMVHSPGYS 241

  Fly   305 VRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLI 369
            ::||:||||||:.|:||..:||....|.|.....::....|.|   ..|: :|...|:||...|.
 Worm   242 IKSDIWSLGITIFELATLTYPYPVGISEFTLSSTIMTSPAPSL---ERGI-YSDSLVEFVERLLQ 302

  Fly   370 KKESDRPKYSRLLEMPFIRRGETSHTDVAVYVAD 403
            |.:.|||....:.|:.|..:.:...:.:...|.|
 Worm   303 KNKDDRPSIVAVQELKFFVKNDIPFSCIGTGVGD 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	101/304 (33%)
sek-4	NP_508915.3	Protein Kinases, catalytic domain	57..324	CDD:473864	95/274 (35%)