Protein Alignment Mkk4 and jkk-1

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_001370369.1
• Gene: jkk-1 / 180810
• WormBaseID: WBGene00002177
• Length: 435
• Species: Caenorhabditis elegans
• Alignment Length: 386
• Identity: 132/386 - (34%)
• Similarity: 193/386 - (50%)
• Gaps: 46/386 - (11%)

  Fly    23 LSLNNLSIRHPPSSTSSTS---SGSTSSGSSSSSQHNHVTRCFGAQQPQQ----TPPVASSQVPP 80
            |.|....:|..|....|||   .....|.:|||.||         |:|..    |.|: ..:..|
 Worm    23 LKLGLTEVRLRPRDRRSTSVDQKHKECSSTSSSPQH---------QRPNNIGYLTSPM-ERKFTP 77

  Fly    81 VPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGE--------------IGRG 131
            :....|.|..|..::.:      :.:|.||...:.|     ||.:||              :|.|
 Worm    78 LSMKPSPSRRDTEKDAL------EYEFLEGYKKSGT-----LEIDGEKQVVDPNEIHIISLLGSG 131

  Fly   132 AFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWI 196
            :.|.|...|.:  .|:||||.:....:::..|::|.|:.::...|. .:||..||....:....|
 Worm   132 SCGVVESATVR--SKLMAVKTMYKNDNKENLKRILRDVRIMSMCNS-PFIVTSYGYFMFDSSVKI 193

  Fly   197 CMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRG 261
            ||::|....:|..:.||..:....||.:...|..:.::||:||||:..|||||:||||||....|
 Worm   194 CMQIMSACCEKLLRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSG 258

  Fly   262 DIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPY 326
            ::|||||||||.:.||:|.:|.|||.|||||||:..|....|||||||||||||:.::.||.:|:
 Worm   259 NVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTGLYPF 323

  Fly   327 RKWDSVFEQLCQVVQ-GEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPF 386
            ...|..|..|..:.. ..|...|.......||..|::|::.||.|...:||:|.:|::..|
 Worm   324 PLNDMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDF 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	108/287 (38%)
jkk-1	NP_001370369.1	PKc_MKK7	106..418	CDD:270791	108/287 (38%)