Protein Alignment Mkk4 and cst-1

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_001024575.2
• Gene: cst-1 / 180708
• WormBaseID: WBGene00017472
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 347
• Identity: 108/347 - (31%)
• Similarity: 175/347 - (50%)
• Gaps: 59/347 - (17%)

  Fly    78 VPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDE--------GEIGRGAFG 134
            :||     |:.::.|:.|             ||.::.....|..|...        |::|.|::|
 Worm     1 MPP-----STDSSRRNSE-------------EGSSDGFKLDSSALNKPPEEVFDIVGKLGEGSYG 47

  Fly   135 AVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICME 199
            :|:|...::...|:|:|::....|.:|   ::.::. :|:..:..|:|::||:.||..|.||.||
 Worm    48 SVHKAIHRESGHVLAIKKVPVDTDLQE---IIKEIS-IMQQCKSKYVVKYYGSYFKHSDLWIVME 108

  Fly   200 LMDT-SLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDI 263
            .... |:..    |...:::.:.|..::.:...|:..|.|| .:||.||||:|..||||:..|..
 Worm   109 YCGAGSISD----IMRARRKPLSEQEISAVLRDTLKGLQYL-HDLKKIHRDIKAGNILLNTDGIA 168

  Fly   264 KLCDFGISGQLVDSIAKTKDAGCRPY-MAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPY- 326
            ||.|||::|||.|::||.......|: ||||.|:   ..|||.::|:||||||.:|:|.|..||
 Worm   169 KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIE---EIGYDTKADIWSLGITAIEMAEGRPPYS 230

  Fly   327 --RKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRR 389
              ....::|     ::..:||.  |.....|:|.||.||:.:|||||..:|....||.|..||:.
 Worm   231 DIHPMRAIF-----MIPTKPPP--TFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFIKN 288

  Fly   390 GETSHTDVAVYVADILESMEKD 411
            ...         .||::.|.:|
 Worm   289 APG---------CDIMQLMIQD 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	98/302 (32%)
cst-1	NP_001024575.2	STKc_MST1_2	31..286	CDD:132943	93/273 (34%)
		Mst1_SARAH	446..493	CDD:463314