Protein Alignment Mkk4 and lic

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: XP_310813.5
• Gene: lic / 1271952
• VectorBaseID: AGAMI1_007155
• Length: 393
• Species: Anopheles gambiae
• Alignment Length: 360
• Identity: 179/360 - (49%)
• Similarity: 233/360 - (64%)
• Gaps: 36/360 - (10%)

  Fly    76 SQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAVNKMT 140
            |.||.    |:..|..|:.::     .|.|..||   .:....:|.|....::||||:|.|.||.
Mosquito    25 STVPD----SAEGATPRNLDK-----RGTLTVGE---RSFVVEADHLRKLADLGRGAYGIVEKML 77

  Fly   141 FKKLDKVMAVKRIRST------------VDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGD 193
            .:....|||||||..|            |..:|||:|||||:|.|::::|.:.||||||||:|||
Mosquito    78 HQPSGTVMAVKRITVTSGMGAGGGPGGGVQSQEQKRLLMDLDVSMRASDCRHTVQFYGALFREGD 142

  Fly   194 CWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLH 258
            .|||||:||||:||||..:|::..|.|||.||.:|.:|.|.||:||..||::|||||||||:|::
Mosquito   143 VWICMEVMDTSVDKFYPVVYKRPGRTIPEYILRQIALAIVRALHYLHTELRVIHRDVKPSNVLMN 207

  Fly   259 RRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDP---ERAKGYDVRSDVWSLGITLMEVA 320
            |||::|:|||||||.||||:|||.||||:||||||||||   .|..|||::|||||||||::|:|
Mosquito   208 RRGEVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIDPGSGSRTAGYDIKSDVWSLGITMVEIA 272

  Fly   321 TGNFPYRKWDSVFEQLCQVVQGEPPRLLTSY--NGMEFSKEFVDFVNTCLIKKESDRPKYSRLLE 383
            ||.|||..|.:.||||.|||:.:||||..|.  :..|||.||..|:.:||.||...|..|..||.
Mosquito   273 TGRFPYATWRTPFEQLKQVVKDDPPRLPKSAHPDADEFSPEFHAFIVSCLQKKYQLRANYEHLLA 337

  Fly   384 MPF--IRRGETSHTD---VAVYVADILESMEKDGI 413
            ..|  :...:....|   :|.||..||:  |:||:
Mosquito   338 TDFLGLYTADAERADNALMAQYVCAILD--ERDGV 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	164/311 (53%)
lic	XP_310813.5	Protein Kinases, catalytic domain	57..340	CDD:473864	159/282 (56%)