Protein Alignment 5-HT2B and HTR1B

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 91/299 - (30%)
• Similarity: 134/299 - (44%)
• Gaps: 46/299 - (15%)

  Fly    33 ETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVLV----LGTAAGNIL 93
            ||....||.:|..:|      |.:....|......:|      |.:|.::|:    |.|...|..
Human    17 ETWVPQANLSSAPSQ------NCSAKDYIYQDSISLP------WKVLLVMLLALITLATTLSNAF 69

  Fly    94 VCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCT 158
            |...:...|:|....||.:.|||:|||:|::||||:..:..|.|.:.||...|..|:..|:..||
Human    70 VIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCT 134

  Fly   159 ASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLP---LSLMYSKNHASVL 220
            |||:|||.|::|||.::...:.:...:|.:|..:.|..||:.||::|||   .....::...|..
Human   135 ASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSEC 199

  Fly   221 VNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLG 285
            |..|..|...||..||:   ||.|   .||...|..|:....|..:                 |.
Human   200 VVNTDHILYTVYSTVGA---FYFP---TLLLIALYGRIYVEARSRI-----------------LK 241

  Fly   286 QAP-ALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDL 323
            |.| ...:|.|..:|:...||:.|||.   |.||...|:
Human   242 QTPNRTGKRLTRAQLITDSPGSTSSVT---SINSRVPDV 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	67/199 (34%)
		TM helix 1	75..101	CDD:320433	7/29 (24%)
		TM helix 2	108..134	CDD:320433	13/25 (52%)
		TM helix 3	146..176	CDD:320433	15/29 (52%)
		TM helix 4	188..211	CDD:320433	9/25 (36%)
		TM helix 5	229..258	CDD:320433	10/28 (36%)
		7tm_GPCRs	<799..893	CDD:475119
		TM helix 6	818..840	CDD:410628
		TM helix 7	854..879	CDD:410628
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	83/264 (31%)
		TM helix 1	51..77	CDD:320455	6/25 (24%)
		TM helix 2	84..110	CDD:320455	13/25 (52%)
		TM helix 3	122..152	CDD:320455	15/29 (52%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	9/22 (41%)
		TM helix 5	205..234	CDD:320455	12/34 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		9/22 (41%)
		TM helix 6	307..337	CDD:320455
		TM helix 7	348..373	CDD:320455
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369