DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and Drd3

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_058836.1 Gene:Drd3 / 29238 RGDID:2521 Length:446 Species:Rattus norvegicus


Alignment Length:825 Identity:171/825 - (20%)
Similarity:243/825 - (29%) Gaps:416/825 - (50%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 YWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGI-LTLVKGY 138
            |:||....|:|....||.|||.|:..||.||..|||.::|||:.||:||.||||..: |.:..|.
  Rat    31 YYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGV 95

  Fly   139 FPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRF----GRNKTRRRVTLKIVFVWL 199
            :......|..::.|||:.|||||::||.||:|||.::..|:.:    |::.. |||.|.|..||:
  Rat    96 WNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSC-RRVALMITAVWV 159

  Fly   200 LSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQ 264
            |:.|:|.||...::......:    |.|.:|.:.:..|:|.||:|.||.:|.|. .:.::.||||
  Rat   160 LAFAVSCPLLFGFNTTGDPSI----CSISNPDFVIYSSVVSFYVPFGVTVLVYA-RIYIVLRQRQ 219

  Fly   265 NLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNH 329
                                 :...|.|:.:....::||....||.|..|               
  Rat   220 ---------------------RKRILTRQNSQCISIRPGFPQQSSCLRLH--------------- 248

  Fly   330 ELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQ-LQYPSS 393
                              .:.||......|         |..||.        ..|:: .|||..
  Rat   249 ------------------PIRQFSIRARFL---------SDATGQ--------MEHIEDKQYPQK 278

  Fly   394 PQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGE 458
            .|....:|.                |..||...||    ||                        
  Rat   279 CQDPLLSHL----------------QPPSPGQTHG----GL------------------------ 299

  Fly   459 QSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYP 523
                                                                ||:.|        
  Rat   300 ----------------------------------------------------KRYYS-------- 304

  Fly   524 RHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVC 588
                                          || .||.|..|                        
  Rat   305 ------------------------------IC-QDTALRHP------------------------ 314

  Fly   589 TCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITG 653
                                                                         .:.|
  Rat   315 -------------------------------------------------------------SLEG 318

  Fly   654 GPAGAAPA-TVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSR 717
            | ||.:|. ...::|||                        |..|   |||:..           
  Rat   319 G-AGMSPVERTRNSLSP------------------------TMAP---KLSLEV----------- 344

  Fly   718 HRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCM 782
               |..|.|.:.|||.|.|.:.     ...|||                                
  Rat   345 ---RKLSNGRLSTSLRLGPLQP-----RGVPLR-------------------------------- 369

  Fly   783 LQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAE 847
                                           |:|||:::.:|...|::.|.|||:.::|.|.|..
  Rat   370 -------------------------------EKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQA 403

  Fly   848 CEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 892
            |  .:|..::...|||||.:|.:||:.||.||..||:||.|:|.|
  Rat   404 C--HVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 77/196 (39%)
TM helix 1 75..101 CDD:320433 11/25 (44%)
TM helix 2 108..134 CDD:320433 15/26 (58%)
TM helix 3 146..176 CDD:320433 16/29 (55%)
TM helix 4 188..211 CDD:320433 12/22 (55%)
TM helix 5 229..258 CDD:320433 10/28 (36%)
7tm_GPCRs <799..893 CDD:475119 34/94 (36%)
TM helix 6 818..840 CDD:410628 7/21 (33%)
TM helix 7 854..879 CDD:410628 10/24 (42%)
Drd3NP_058836.1 7tmA_D3_dopamine_R 30..440 CDD:320436 166/817 (20%)
TM helix 1 31..57 CDD:320436 11/25 (44%)
TM helix 2 64..87 CDD:320436 14/22 (64%)
TM helix 3 103..133 CDD:320436 16/29 (55%)
TM helix 4 150..168 CDD:320436 8/17 (47%)
TM helix 5 185..210 CDD:320436 10/25 (40%)
TM helix 6 368..398 CDD:320436 12/92 (13%)
TM helix 7 408..433 CDD:320436 10/24 (42%)

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