DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT2B and Htr1a

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_036717.2 Gene:Htr1a / 24473 RGDID:2845 Length:422 Species:Rattus norvegicus


Alignment Length:855 Identity:149/855 - (17%)
Similarity:225/855 - (26%) Gaps:475/855 - (55%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 GNATISATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLM 121
            ||.|   :..||.|......:||...|:.....||..|..|||.||.||||.||.:.|||:||||
  Rat    23 GNVT---SISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLM 84

  Fly   122 VAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKT 186
            |:|||:|:..|..|...:.||...|..:|.||||.||:||:|||.|::|||.::..|:.:...:|
  Rat    85 VSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRT 149

  Fly   187 RRRVTLKIVFVWLLSIAMSLPLSLMY--------------SKNHASVLVNGTCQIPDPVYKLVGS 237
            .||....|...||:...:|:|..|.:              ||:|.              |.:..:
  Rat   150 PRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHG--------------YTIYST 200

  Fly   238 IVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKP 302
            ...|||||.:||:.|                             |.:.:|.....|.|.|::.|.
  Rat   201 FGAFYIPLLLMLVLY-----------------------------GRIFRAARFRIRKTVRKVEKK 236

  Fly   303 GPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVA 367
            |.|                                                              
  Rat   237 GAG-------------------------------------------------------------- 239

  Fly   368 SSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVL 432
                                                                             
  Rat   240 ----------------------------------------------------------------- 239

  Fly   433 GLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDAD 497
                |:||                                        :|:.|            
  Rat   240 ----TSLG----------------------------------------TSSAP------------ 248

  Fly   498 EDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELD 562
                                                                             
  Rat   249 ----------------------------------------------------------------- 248

  Fly   563 PPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSP 627
            ||:|:    :.||....|:                 :.|.::..|                    
  Rat   249 PPKKS----LNGQPGSGDW-----------------RRCAENRAV-------------------- 272

  Fly   628 SEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAP 692
                                                                             
  Rat   273 ----------------------------------------------------------------- 272

  Fly   693 GTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRS 757
            ||||          |...|        |:|..    ..:|.:........|....||...:...|
  Rat   273 GTPC----------TNGAV--------RQGDD----EATLEVIEVHRVGNSKEHLPLPSESGSNS 315

  Fly   758 HQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLG 822
            :                    :|..|:|:.. |:..::....::|           |:|..|.||
  Rat   316 Y--------------------APACLERKNE-RNAEAKRKMALAR-----------ERKTVKTLG 348

  Fly   823 VVFFTFVILWSPFFVLNLLPTVCAECEERISHW---VFDVVTWLGYASSMVNPIFYTIFNKVFRQ 884
            ::..||::.|.|||::.|:...|    |...|.   :..::.||||::|::||:.|..|||.|:.
  Rat   349 IIMGTFILCWLPFFIVALVLPFC----ENSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQN 409

  Fly   885 AFKKVLLCRY 894
            ||||::.|::
  Rat   410 AFKKIIKCKF 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 72/206 (35%)
TM helix 1 75..101 CDD:320433 9/25 (36%)
TM helix 2 108..134 CDD:320433 15/25 (60%)
TM helix 3 146..176 CDD:320433 17/29 (59%)
TM helix 4 188..211 CDD:320433 7/22 (32%)
TM helix 5 229..258 CDD:320433 9/28 (32%)
7tm_GPCRs <799..893 CDD:475119 32/96 (33%)
TM helix 6 818..840 CDD:410628 9/21 (43%)
TM helix 7 854..879 CDD:410628 9/27 (33%)
Htr1aNP_036717.2 7tmA_5-HT1A_vertebrates 37..411 CDD:320453 138/828 (17%)
TM helix 1 38..64 CDD:320453 9/25 (36%)
TM helix 2 71..97 CDD:320453 15/25 (60%)
TM helix 3 109..139 CDD:320453 17/29 (59%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 133..135 1/1 (100%)
TM helix 4 151..173 CDD:320453 7/21 (33%)
TM helix 5 192..221 CDD:320453 11/71 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..261 13/277 (5%)
TM helix 6 338..368 CDD:320453 13/40 (33%)
TM helix 7 379..404 CDD:320453 8/24 (33%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 396..400 2/3 (67%)

Return to query results.
Submit another query.