DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and Htr2c

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_032338.3 Gene:Htr2c / 15560 MGIID:96281 Length:459 Species:Mus musculus


Alignment Length:856 Identity:159/856 - (18%)
Similarity:239/856 - (27%) Gaps:495/856 - (57%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 TGNATISATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDL 120
            |.|::........|....|:.||..:|:::.|..|||||.:|::.|::|.|.||||||||||.|:
Mouse    37 TFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADM 101

  Fly   121 MVAVLVMPLGILTLVKGY-FPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRN 184
            :|.:|||||.:|.::..| :||....|..||.|||||.||||||||.||:|||:::|.|:...|.
Mouse   102 LVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRF 166

  Fly   185 KTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNG-TCQIPDPVYKLVGSIVCFYIPLGVM 248
            .:|.:..:||..||.:||.:|:|:.::..::.:.|.||. ||.:.||.:.|:||.|.|:|||.:|
Mouse   167 NSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIM 231

  Fly   249 LLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHA 313
            ::||.||:.:|.||                                                   
Mouse   232 VITYFLTIYVLRRQ--------------------------------------------------- 245

  Fly   314 HSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKS 378
                                                      .|.|.||                
Mouse   246 ------------------------------------------TLMLLRG---------------- 252

  Fly   379 EFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIER 443
                                                                             
Mouse   253 ----------------------------------------------------------------- 252

  Fly   444 ESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLR 508
                                                                             
Mouse   253 ----------------------------------------------------------------- 252

  Fly   509 RHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIA 573
                                                           |::.||            
Mouse   253 -----------------------------------------------HTEEEL------------ 258

  Fly   574 GQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSG 638
             :|...::|:    |.|.. ||.                      ...|.:.:|.:.        
Mouse   259 -RNISLNFLK----CCCKK-GDE----------------------EENAPNPNPDQK-------- 287

  Fly   639 NKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLS 703
                                                                      |.|:|  
Mouse   288 ----------------------------------------------------------PRRKK-- 292

  Fly   704 ISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGE 768
                        ...|.||                               |:::..|        
Mouse   293 ------------KEKRPRG-------------------------------TMQAINN-------- 306

  Fly   769 CGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWS 833
                                                         |:||:||||:|||.|:|:|.
Mouse   307 ---------------------------------------------EKKASKVLGIVFFVFLIMWC 326

  Fly   834 PFFVLNLLPTVCAE-CEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSST 897
            |||:.|:|..:|.: |.:::...:.:|..|:||..|.:||:.||:|||::|:||.|.|.|.|...
Mouse   327 PFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPD 391

  Fly   898 SAWRPSRXQTP 908
            .  :|.. |.|
Mouse   392 K--KPPVRQIP 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 91/194 (47%)
TM helix 1 75..101 CDD:320433 10/25 (40%)
TM helix 2 108..134 CDD:320433 18/25 (72%)
TM helix 3 146..176 CDD:320433 21/29 (72%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 15/28 (54%)
7tm_GPCRs <799..893 CDD:475119 37/94 (39%)
TM helix 6 818..840 CDD:410628 13/21 (62%)
TM helix 7 854..879 CDD:410628 9/24 (38%)
Htr2cNP_032338.3 7tmA_5-HT2C 55..386 CDD:341346 151/820 (18%)
TM helix 1 56..82 CDD:341346 10/25 (40%)
TM helix 2 89..115 CDD:341346 18/25 (72%)
TM helix 3 128..158 CDD:341346 21/29 (72%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 152..154 1/1 (100%)
TM helix 4 170..193 CDD:341346 8/22 (36%)
TM helix 5 212..241 CDD:341346 15/28 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..302 10/160 (6%)
TM helix 6 305..335 CDD:341346 18/82 (22%)
TM helix 7 348..373 CDD:341346 9/24 (38%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 365..369 2/3 (67%)
PDZ-binding 457..459
Blue background indicates that the domain is not in the aligned region.

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