Protein Alignment 5-HT2B and Htr2b

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_006529209.1
• Gene: Htr2b / 15559
• MGIID: 109323
• Length: 495
• Species: Mus musculus
• Alignment Length: 967
• Identity: 178/967 - (18%)
• Similarity: 273/967 - (28%)
• Gaps: 558/967 - (57%)

  Fly    21 SSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISATFE---DVPFDANN-YW-ALLA 80
            ::|||::       |:|..         |:...|.:|..|.|...|   .|....:. :| |||.
Mouse    12 TTSEHIL-------QKTCD---------HLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLI 60

  Fly    81 LVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLV-KGYFPLGSE 144
            |.:::.|..|||||.||:|.|:|||..||||||||||.||:|.:.|||:.:||:: :..:||...
Mouse    61 LAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLA 125

  Fly   145 HCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAM-SLPL 208
            .|..|:.|||||.||||||||.||:|||::::.|::..:..:|....:||..|||:||.| .:||
Mouse   126 LCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGMWGMPL 190

  Fly   209 SLMYSKNHASVLV----------------NGTCQIPDP---VYKLVGSIVCFYIPLGVMLLTYCL 254
             ..|.:|.:|.:.                |.||::...   .:.:.||:..|:.||.:|::||.|
Mouse   191 -FPYGQNASSGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFL 254

  Fly   255 TVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANST 319
            |:..|.::..                                  |:|..|
Mouse   255 TIHTLQKKAY----------------------------------LVKNKP--------------- 270

  Fly   320 DTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSN 384
                                                                             
Mouse   271 ----------------------------------------------------------------- 270

  Fly   385 HLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNS 449
                     |||                                     |:..|:
Mouse   271 ---------PQR-------------------------------------LTRWTV---------- 279

  Fly   450 LASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHN 514
                                                                 ||..||.
Mouse   280 -----------------------------------------------------PTVFLRE----- 286

  Fly   515 SLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQS 579
                                                                             
Mouse   287 ----------------------------------------------------------------- 286

  Fly   580 DYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLT 644
                                           .|:|          |||.::.:|
Mouse   287 -------------------------------DSSF----------SSPEKVAML----------- 299

  Fly   645 SSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTAS 709
                                                   |||
Mouse   300 ---------------------------------------DGS----------------------- 302

  Fly   710 VVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTR 774
                    ||                 .|....|:..|.:||.:::               ||
Mouse   303 --------HR-----------------DKILPNSSDETLMRRMSSV---------------GK-- 325

  Fly   775 TTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLN 839
                                |::..||.           ||:|:|.||||||.|:::|.|||:.|
Mouse   326 --------------------RSAQTISN-----------EQRASKALGVVFFLFLLMWCPFFITN 359

  Fly   840 LLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWR--- 901
            |...:|..|.:.....:.::..|:||.||.|||:.||:|||.||:||.:.:.|.|.:|.:.:
Mouse   360 LTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALR 424

  Fly   902 -----------------------------PSRXQTPVKPGKLKTNTHKCASVDFQDS 929
                                         |:..|:|:   :|:::|.:.:|:...|:
Mouse   425 KFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPM---RLRSSTIQSSSIILLDT 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	87/215 (40%)
		TM helix 1	75..101	CDD:320433	14/26 (54%)
		TM helix 2	108..134	CDD:320433	17/25 (68%)
		TM helix 3	146..176	CDD:320433	20/29 (69%)
		TM helix 4	188..211	CDD:320433	10/23 (43%)
		TM helix 5	229..258	CDD:320433	10/31 (32%)
		7tm_GPCRs	<799..893	CDD:475119	38/93 (41%)
		TM helix 6	818..840	CDD:410628	12/21 (57%)
		TM helix 7	854..879	CDD:410628	10/24 (42%)
Htr2b	XP_006529209.1	7tm_GPCRs	54..413	CDD:475119	156/839 (19%)
		TM helix 1	56..80	CDD:410628	12/23 (52%)
		TM helix 2	89..111	CDD:410628	15/21 (71%)
		TM helix 3	128..150	CDD:410628	15/21 (71%)
		TM helix 4	173..205	CDD:410628	13/32 (41%)
		TM helix 5	230..253	CDD:410628	7/22 (32%)
		TM helix 6	338..360	CDD:410628	12/21 (57%)
		TM helix 7	374..399	CDD:410628	10/24 (42%)