DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and adra2c

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_001120375.1 Gene:adra2c / 100145449 XenbaseID:XB-GENE-5773399 Length:433 Species:Xenopus tropicalis


Alignment Length:855 Identity:159/855 - (18%)
Similarity:236/855 - (27%) Gaps:450/855 - (52%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 PFDANNYWALLALV--LVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGI 131
            |:...:.|.|.|:|  |::.|..||:.|.:|:...|.|:...|.||:|||..|::||.||||..:
 Frog    25 PYSMTSVWCLAAIVGFLIIFTIVGNVFVVIAVLTSRALKAPQNLFLVSLASADILVAALVMPFSL 89

  Fly   132 LTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVF 196
            ...:.||:..|:..|..::.|||||||:||:|||.||:|||.|:...:.:...:|.||:...||.
 Frog    90 ANELMGYWYFGNVWCDIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRIKGIIVT 154

  Fly   197 VWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIV-CFYIPLGVMLLTYCLTVRLLA 260
            |||:|..:|.| .|:.........|...|::.|..:.::.|.: .|:.|..:|:|.|   :|:. 
 Frog   155 VWLISAVISFP-PLISMDRDTEDDVYPQCKLNDDTWYILSSCIGSFFAPCIIMILVY---IRIY- 214

  Fly   261 RQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLST 325
                                     |...|..|                                
 Frog   215 -------------------------QVAKLRTR-------------------------------- 222

  Fly   326 LDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQY 390
                       ::.|..||...:.|                         |::.||         
 Frog   223 -----------TLSEKKPTRDGSSH-------------------------TENGFS--------- 242

  Fly   391 PSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRM 455
                                                .||||                        
 Frog   243 ------------------------------------KGTTV------------------------ 247

  Fly   456 GGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNA 520
                                       .:|| :|..||                      .|...
 Frog   248 ---------------------------KMPG-DKENGH----------------------CPPRP 262

  Fly   521 LYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLP 585
            ..|:.|      |.:|.|.|||:..:.::.||.....:|:....:|                   
 Frog   263 SPPKAT------DVEDLELEESSMSESKRRKSSSKEDNTDSSKERK------------------- 302

  Fly   586 SVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAG 650
                                                             ||.||           
 Frog   303 -------------------------------------------------CSKGN----------- 307

  Fly   651 ITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDS 715
                                                                |.||.:|      
 Frog   308 ----------------------------------------------------SFSKQSS------ 314

  Fly   716 SRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSP 780
                                  :.:.|||.|..|                               
 Frog   315 ----------------------RLSRTSNKSMEL------------------------------- 326

  Fly   781 CMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVC 845
                    ..|...:..|.:||......|    |::.|.||.||...||:.|.|||....|..:|
 Frog   327 --------FSSRKKKKRSSVSRRKLSQAR----EKRFTFVLAVVMGVFVVCWFPFFFSYSLYGIC 379

  Fly   846 AE-CEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWRPSRXQTPV 909
            .| ||  :...:|....|:||.:|.:||:.|||||:.||::|||::..                 
 Frog   380 REACE--VPETLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSFKKIICI----------------- 425

  Fly   910 KPGKLKTNTH 919
              |:.||.||
 Frog   426 --GRRKTFTH 433

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 69/195 (35%)
TM helix 1 75..101 CDD:320433 10/27 (37%)
TM helix 2 108..134 CDD:320433 13/25 (52%)
TM helix 3 146..176 CDD:320433 19/29 (66%)
TM helix 4 188..211 CDD:320433 10/22 (45%)
TM helix 5 229..258 CDD:320433 7/29 (24%)
7tm_GPCRs <799..893 CDD:475119 37/94 (39%)
TM helix 6 818..840 CDD:410628 11/21 (52%)
TM helix 7 854..879 CDD:410628 10/24 (42%)
adra2cNP_001120375.1 7tmA_alpha2C_AR 32..419 CDD:320446 150/813 (18%)
TM helix 1 33..59 CDD:320446 9/25 (36%)
TM helix 2 66..92 CDD:320446 13/25 (52%)
TM helix 3 104..134 CDD:320446 19/29 (66%)
TM helix 4 146..169 CDD:320446 11/23 (48%)
TM helix 5 187..216 CDD:320446 7/57 (12%)
TM helix 6 346..376 CDD:320446 13/33 (39%)
TM helix 7 387..412 CDD:320446 10/24 (42%)

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