Protein Alignment CG7352 and MNS1

DIOPT Version :10

• Sequence 1: NP_649795.1
• Gene: CG7352 / 40997
• FlyBaseID: FBgn0037581
• Length: 466
• Species: Drosophila melanogaster
• Sequence 2: NP_060835.1
• Gene: MNS1 / 55329
• HGNCID: 29636
• Length: 495
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 110/450 - (24%)
• Similarity: 221/450 - (49%)
• Gaps: 71/450 - (15%)

  Fly    39 QLFRKLQ-----YDLEE-VSRSQELSKVSPITRDFIEEAAMTQEMQDLKRAEFVERKRRQQLRRD 97
            |..|.||     .|:|| :.:::|..::..:  ...:|..:..|:..||.....:.|.|||:|.:
Human    55 QFLRLLQNEQFELDMEEAIQKAEENKRLKEL--QLKQEEKLAMELAKLKHESLKDEKMRQQVREN 117

  Fly    98 CEELRDLAEQLRLAAISRDIAENLEEKKRRRQLDIKLEAAEVSQERCLLEVRQR--EKEVALKEE 160
            ..|||:|.::|:.|.::::.|..:.||...:...:|.: ||::  :.::|..:|  ::|.|.:::
Human   118 SIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRD-AEIA--KTMMEEHKRIIKEENAAEDK 179

  Fly   161 QRRLRE----SLAEQMEENRRRRLQEHAQVMNDRELSLLMQKQIQEEDRAQELEAQRKKLQKRQD 221
            :.:.:.    .|.:|:||..:::.:.:.|::.::.:...:.::|.|||   :||.| :||:|...
Human   180 RNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEED---QLEKQ-QKLEKMNA 240

  Fly   222 MLRSIKENQELREWQRAQYNQELSDLVQKQSDMERRKLQLEAERQEIQRKKQEISIRLGQQVLEI 286
            |.|.|:|.|:.:...|.:..:|:.:        |.||: :|....:.||::..::     :|.|.
Human   241 MRRYIEEFQKEQALWRKKKREEMEE--------ENRKI-IEFANMQQQREEDRMA-----KVQEN 291

  Fly   287 ENKKRHRDNLLLDLLEAEYTAKSD-ERYRQQMQQEQMS---RQRTRQELDRYRQEVKHRKMAEM- 346
            |.|:....|.|...||.....:.| |:.||::.||:.:   :.:.::|.::     |.||..||
Human   292 EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK-----KLRKQKEMK 351

  Fly   347 -----QMKRAEM---ATRQEE------------APDTIN-QNSEKQ-LDEYRRRRAHGASLLAMI 389
                 ||...|:   |.::||            ..|.|. .|::|| :.:...|||    :..:|
Human   352 QDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRA----VEKLI 412

  Fly   390 EDNHRKRAEATAENVQYFDMKAKIDAEQEERIKQERLAMLSQVPSSVLRYLPKHVLKSTD 449
            |:..::........::.:.::.:........|::|||.:|.:..:::|.||||.|.|..|
Human   413 EERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKED 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7352	NP_649795.1	TPH	94..431	CDD:464007	86/369 (23%)
MNS1	NP_060835.1	Interaction with BBOF1. /evidence=ECO:0000250|UniProtKB:Q61884	1..314		69/281 (25%)
		TPH	114..454	CDD:464007	86/369 (23%)