Protein Alignment CG2747 and Heatr5a

DIOPT Version :10

• Sequence 1: NP_001262364.1
• Gene: CG2747 / 40950
• FlyBaseID: FBgn0037541
• Length: 2172
• Species: Drosophila melanogaster
• Sequence 2: XP_038934067.1
• Gene: Heatr5a / 362737
• RGDID: 1561116
• Length: 2052
• Species: Rattus norvegicus
• Alignment Length: 2181
• Identity: 968/2181 - (44%)
• Similarity: 1369/2181 - (62%)
• Gaps: 191/2181 - (8%)

  Fly    49 MELAHTLILNEDALKQLPEHKRPVFELEWLRYLEKALPLVSKAEIKASQKKLVQQLSERIQGAPG 113
            |||||:|:|||:|..||.:.::..|..||||||||.|...::.:::..||.||:||...:..:||
  Rat     1 MELAHSLLLNEEASNQLGDVQKAEFVFEWLRYLEKLLLATNRDDVREKQKALVEQLLSLLSSSPG 65

  Fly   114 PPIRKLIASALATLFSVGDTFMLFDTVNACNDILKNKDDSPSYLPTKLAAICVLGSMYEKLGRMM 178
            ||.|||:|..||.|:|:||||.:::|::.|||::::||||||||||||||:..|||:|:||||::
  Rat    66 PPTRKLLAQNLAILYSIGDTFSVYETIDKCNDLIRSKDDSPSYLPTKLAAVVCLGSLYKKLGRIL 130

  Fly   179 GRTYEDTVQILIRTLRNAESQARIEIMHTLEKVSAGMGTAIANVHKDIYKAAKHCLLDRVMAVRV 243
            ...:.|||..:::.:::||||.|.|||.:|:.:..|:|.|.|..|:|:||||:.||.||.||||.
  Rat   131 ANGFTDTVGNILKAVKSAESQGRYEIMLSLQSILTGLGAAAAPCHRDVYKAARSCLTDRSMAVRC 195

  Fly   244 AAARCILKMIYSAPFLYQTELESLGTLCFRAFDGSNYEVRCAVAQLLGTLLAYTQQLAEAATSKK 308
            |||:|:|::...|.|::.|:|:|:.||||::|:||||:||.:|::||||:      ||:|..:|.
  Rat   196 AAAKCLLELQNEAIFMWSTDLDSVATLCFKSFEGSNYDVRISVSKLLGTV------LAKAVIAKH 254

  Fly   309 KQGQAVAIQAGKGATQRLVSLDEALGILMSGFLRGGASFLKGTGEIIKGSSGVNREVRVGVTHAY 373
            ..|     .|.:.:|:| |||:|.|.:|.:|||||.:.||:.:|:::||||.|:|:||||||.||
  Rat   255 PGG-----AASRQSTRR-VSLEEVLELLGAGFLRGSSGFLRASGDMLKGSSSVSRDVRVGVTQAY 313

  Fly   374 VVFVQFMGSVWLERQLSTFLAHVLDLV--ANPKAACSHVDAVYSRKCISFILRSTIGKMLGEKAQ 436
            ||||..:|..|||:.|:.||:|:|.||  :||||..:.:|||..|:|:|||||:|||.:||||||
  Rat   314 VVFVSTLGGAWLEKNLAVFLSHILSLVSQSNPKATQTQIDAVCCRRCVSFILRATIGGLLGEKAQ 378

  Fly   437 SAACKELVHLVAKQMNSIDFNPENAKDSNQETLF-------SQHLLVCALQELSSLLIGLGTTAQ 494
            .||.|::...:.|....:|   ....|.|.||..       |||:||||||||.:|:..|||||.
  Rat   379 IAAAKDICQAIWKLKKVMD---AVLSDGNLETRLSSTDVAASQHMLVCALQELGNLIHSLGTTAA 440

  Fly   495 NLLGDQSLQAIDATCAVLVHPCAAARLAAAWCLRCACVAVPGQITPLIDRFVEAIEQMRSSPEAM 559
            .||.|.|...:|:..:|::||..:.||||||||.|..||:|..:|||:||.:|.:..::|||||:
  Rat   441 PLLQDSSTGLLDSVISVVLHPSISVRLAAAWCLHCIAVALPSYLTPLLDRCLERLTTLKSSPEAV 505

  Fly   560 AGYSCALAAILGSVRYSPLGIPHTKGK-VVFNCAEELLRSASQNSRMSLHRTQAGWLLIGAIMTL 623
            .|:|.|:||:||:|.:.||||||.||| ::...||:||.||:||||:||.|||||||||.|:|||
  Rat   506 TGFSFAVAALLGAVTHCPLGIPHGKGKQIIMTLAEDLLCSAAQNSRLSLQRTQAGWLLISALMTL 570

  Fly   624 GSPVVKGLLPRMLLLWRNSFPRSNKELESEKARGDAFTWQVTLEGRAGALSVMHSFLLNCPDLLN 688
            |..||...|||:||||:..||.|.|:||:|::|||:||||||||||||||..:.||:.:|.|||.
  Rat   571 GPAVVSHHLPRVLLLWKCVFPVSPKDLETERSRGDSFTWQVTLEGRAGALCAVKSFISHCGDLLT 635

  Fly   689 EDITRRLLTPIESALAMLVNLASVLKSYGTQLKAPAAMVRLRLFETLTLLPANALEASYTHLLRM 753
            |::.:|||.|:..|:.:|..|:|:||:||:.||.|:.:.|.||:|.|.|||....:.:...:|:.
  Rat   636 EEVIQRLLPPLPCAVDLLTQLSSILKTYGSSLKTPSVVYRQRLYELLILLPPETYKGNLCAILKE 700

  Fly   754 LVSEFTLSDNAANTTNSLLRTLCHGDDSIILGTWLQETNHRTIEDQMEPNRKVDGEHLQPNSAAG 818
            :.:|.|..|:....:..||..|||.||.:||...||||:||.||:|:          |..|..|
  Rat   701 VAAELTAPDSQVAASACLLPALCHPDDLLILSPLLQETDHRFIEEQL----------LFGNGIA- 754

  Fly   819 SGALEHDPCCLYRPRSAQGNGSSSNGSSATSTGGSNGGGGSNIQQISKAQQCPGPLPLGVAVIDM 883
            .|:||:||..:|. :..:|:                              ..|.|||..::||..
  Rat   755 CGSLEYDPYSIYE-KDVEGD------------------------------SVPKPLPPALSVISS 788

  Fly   884 AVTLYGTIFPKVANKHRLQMLEHFTECIRQAKSSRQEAVQMNIFTALLCALKNLTDSKTSLGQED 948
            |..|:|.:...|....|:.:|:.....|:..|.:||:.||:::.:|:...||.:..||.|||.|
  Rat   789 ASKLFGVVCANVDEAQRVLILDQLLNSIKHTKGARQQTVQLHVVSAISNLLKYVAGSKQSLGPE- 852

  Fly   949 VRKSATALIVASLTSANSTIRCAAGEALGRLAQVVGDSHFTAELAQNSFDKLKSARDVVTRTGHS 1013
            ||:....|::.:|.|.|..:||||.||..||||||.|..|||.|||.||||||||||||||||||
  Rat   853 VRRLVLTLVLGALESPNPLLRCAAAEAWARLAQVVDDGAFTAGLAQVSFDKLKSARDVVTRTGHS 917

  Fly  1014 HALGCLHRYVGGMGSSQHLSTSVSILLALGQDSASPVVQAWSLYALAQIADSGGPMFRGYVEATL 1078
            .|||.||||:||:| .||||:.:.:|..|.|||.||.||.|:|::|:...||.|.::..:||:||
  Rat   918 LALGSLHRYLGGIG-PQHLSSCIGVLYTLSQDSTSPDVQTWALHSLSLTIDSAGALYHVHVESTL 981

  Fly  1079 TLCLKLLLTVPHAHVDVHQCVGRVVNALITTVGPELQGGGGAVATMRGSFLCSAALLQSHSDPLV 1143
            :|.:.|||.||..|..|||.:||.:||||||:||||||...:|:.:|.|.|...|::|.|...||
  Rat   982 SLIVMLLLNVPPTHAQVHQSLGRCLNALITTLGPELQGNNTSVSALRTSCLLGCAVMQDHPGCLV 1046

  Fly  1144 QAEAIGCLQQLHLFASKSLQLEELVPTLVGMLACN---------YFILRKASVSCLRQLAHREAK 1199
            ||:||.||||||:||.:.:.|..||..|..:|..|         |.:||:|.::|||||..|||.
  Rat  1047 QAQAISCLQQLHMFAPRHVNLSSLVSCLCEILLDNSVLVNLCSPYLLLRRAVLACLRQLVQREAA 1111

  Fly  1200 EVCELALTI---NAEQLP--DLVITEYGLPGLLFSLLDTETDAEMLRNIHDTLTSMLQMLAADNL 1259
            ||.|.|:.:   |.:..|  |..:.|.||.|.|.:|||.|||..:.::|.:||..||..:|.:.|
  Rat  1112 EVSEHAVMLARDNRDNNPAADTNLREVGLEGALLALLDRETDGSLCQDIRETLHHMLTSMAVEKL 1176

  Fly  1260 SSWLSLCKNVLTVAVEGGLNDDPAAGEQSKSKEAGGEDDEEDEEEEYADDVTEYRAEENTSTHPA 1324
            |.||.|||:||..:.:              .......|..::||.:..||.:.....:: ..||.
  Rat  1177 SLWLKLCKDVLAASAD--------------FTAVTCVDTMQEEEGDRGDDASVLTRGDD-KPHPF 1226

  Fly  1325 VQPRWPTRVFAAQCVRRIIASCEAASSVHFDLLQAKEQQLIRSRGDYLILHLAELIRMSFMAATS 1389
            ..|||.||||||.||.|||:.||.|:|.|||:..|:|.:...||.|:|:||||:||||:|||||.
  Rat  1227 SNPRWGTRVFAADCVCRIISQCENANSAHFDIALAQEMKKSDSRNDFLVLHLADLIRMAFMAATD 1291

  Fly  1390 DSDQLRLEGLRTLQEIIDRFANVPEPEFPGHLLLEQFQAQVGAALRPAFAPDTPSHVTAAACEVC 1454
            .||||||.||.||..:|.|||::.|||||||::|||:||.|||||||||..:||..:||.||:||
  Rat  1292 HSDQLRLSGLDTLLVVIRRFADIAEPEFPGHVILEQYQANVGAALRPAFTSETPPDITAKACQVC 1356

  Fly  1455 SAWIGSGVARDIGDLKRVHQLLVSSLDKL-SSKTNSTQLYNESMATLEKLSILKAWAEVYIVAMI 1518
            ||||.|||..|:|||:||||||||||.|: :.|...:||||||.:|:|.|::|||||||||:|
  Rat  1357 SAWIASGVVSDLGDLRRVHQLLVSSLMKIQAGKEALSQLYNESASTMEVLAVLKAWAEVYIIA-- 1419

  Fly  1519 GNGKAPASLLNLQSQQSGFQSL-TNLETDSDVPDSRGES--LLGLVQPELHNLSTHWLSAMKDHA 1580
                       :|..::..|:| |.:.::..|......:  ||.||..:|..||..||:|::|.|
  Rat  1420 -----------VQRHKNHKQTLKTTINSEDSVRSGSASAAGLLDLVCTDLATLSRLWLAALQDFA 1473

  Fly  1581 LLLLPAEFQSQLPHDGGAFYTTDTINSSKPHYMTSWPPILYASALWLRDEGFARHLDTSEAAAES 1645
            ||.|||||.||||.:||||||.:|..|:.|||..||..||:|:||||...|||   |..|..|..
  Rat  1474 LLTLPAEFASQLPVEGGAFYTAETSKSATPHYHNSWALILHAAALWLTSTGFA---DPDEGGANL 1535

  Fly  1646 NN----NQITHGSLSA------------DRFHMIFGICMEALCSMRSSERPRNIVSCLRSLHSIF 1694
            :.    ..:..||.|:            ||||:|.||.:|.|||:||.....:|.|||::|.::.
  Rat  1536 SRPVTPTSMCQGSSSSGPAVKSPEDVYTDRFHLILGISVEFLCSLRSDATLESITSCLQALQALL 1600

  Fly  1695 DSDWARRQLVKDRALTIELCHVLHRQILTRDELLVQLLCVEILKQTIRAAREDLERKR-----DD 1754
            |:.|.|.::..|:.|.|||.:||||.||||:...:||..:|:::|.|.||:|.::.||     ||
  Rat  1601 DAPWPRSRVGSDQDLGIELLNVLHRVILTRESPAIQLASLEVVRQIICAAQEHVKEKRRSAEVDD 1665

  Fly  1755 NANSED-----GKGGERHGEDDSMQPGSSHVYAVLEVCLCLFVRQIPTMNPTRQGAGGSGLQLDF 1814
            .|:.::     |:|.:..|    :.||.|.|:|.||:|:|:.|||:|.:||
  Rat  1666 GASEKETVPEFGEGKDTGG----LVPGKSLVFATLELCVCILVRQLPELNP-------------- 1712

  Fly  1815 AYAKMATG----SSFFSVLGDENGLLVSSGLQCVEQLMDLCTPKGALAILPTVLYMTTSIVKEIA 1875
               |:.:|    :|....|.:|...||::.|..:.:|..:|:|:|::::|||:||:...:::|.|
  Rat  1713 ---KLTSGPRDKASKPKTLSEEGSRLVAAALVILAELPAVCSPEGSVSVLPTILYLAIGVLRETA 1774

  Fly  1876 NK---SAIDSTILANTCAVKSALQCLRSVCVHKWAKVEETTEEWQQLLQSALATIVDLTKTAGDN 1937
            .|   ..:.||:.|       :|..|:.:.....|:.|::.|.|..||||||||::|..... |.
  Rat  1775 VKLPGGQLSSTVTA-------SLHALKGILTSPMARAEKSHEAWTSLLQSALATVLDCWSPV-DG 1831

  Fly  1938 EERKVDEVTMLLAITVFILHTPASVVATPSLQYPCINHFRQCLQSENLSVKLRCIETTRSIFARA 2002
            ..:::||:::|.|||||||.|...|.|.|.||..||..|:..|:|::..|:::..:...|||...
  Rat  1832 AHQELDEISLLTAITVFILSTSPEVTAVPCLQNRCIEKFKAALESKDSVVQMKTCQLLHSIFQYP 1896

  Fly  2003 ELKTATPYIHALAPRIIESLYAESSKVPTSELELQVTLESIVTVEQLIDLSEPQNRNMNLLQDIQ 2067
            :...:.|||::||..|:|.|.....:.|....|||:..|.|..:|.|:.:::.::|       .|
  Rat  1897 KPAISYPYIYSLASSIVEKLQEMDRRRPGDAAELQLCQEGIKLLEALVTVADEEHR-------AQ 1954

  Fly  2068 MLTLLVPVLIGFLAEPSRLRTLPKYQRQLHDQALQWLLKIGPKYPQEFKALMGQTPELRQKLEAA 2132
            ::..|:|:||.||.:.:.|.:.....|.|||.|||.|::|||:|...||.:|..:|.|:.:||||
  Rat  1955 LVACLLPILISFLLDENALGSATSVTRSLHDFALQTLMQIGPRYSSVFKNVMASSPALKARLEAA 2019

  Fly  2133 IRSQQQSINIAQKASEAQRNLLAKPQKPTIKLKTDF 2168
            ::..|:|:.:...:.:| :||   .:..:|:|||.|
  Rat  2020 VKGNQESVRVDPSSKQA-KNL---GRNSSIQLKTSF 2051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2747	NP_001262364.1	HEAT repeat	145..173	CDD:293787	19/27 (70%)
		HEAT repeat	185..213	CDD:293787	11/27 (41%)
		HEAT repeat	225..255	CDD:293787	18/29 (62%)
		HEAT repeat	266..292	CDD:293787	15/25 (60%)
		Laa1_Sip1_HTR5	1371..1581	CDD:466361	115/213 (54%)
Heatr5a	XP_038934067.1	HEAT repeat	97..121	CDD:293787	16/23 (70%)
		HEAT repeat	137..165	CDD:293787	11/27 (41%)
		HEAT repeat	177..207	CDD:293787	18/29 (62%)
		HEAT repeat	218..244	CDD:293787	15/25 (60%)
		Laa1_Sip1_HTR5	1273..1474	CDD:466361	115/213 (54%)