Protein Alignment CG2747 and Heatr5b

DIOPT Version :10

• Sequence 1: NP_001262364.1
• Gene: CG2747 / 40950
• FlyBaseID: FBgn0037541
• Length: 2172
• Species: Drosophila melanogaster
• Sequence 2: NP_001074648.1
• Gene: Heatr5b / 320473
• MGIID: 2444098
• Length: 2070
• Species: Mus musculus
• Alignment Length: 2192
• Identity: 1064/2192 - (48%)
• Similarity: 1445/2192 - (65%)
• Gaps: 195/2192 - (8%)

  Fly    49 MELAHTLILNEDALKQLPEHKRPVFELEWLRYLEKALPLVSKAEIKASQKKLVQQLSERIQGAPG 113
            |||||:|:|||:||.|:.|.|||||..||||:|:|.|...:|.::|..|||||:||:..|..:||
Mouse     1 MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPG 65

  Fly   114 PPIRKLIASALATLFSVGDTFMLFDTVNACNDILKNKDDSPSYLPTKLAAICVLGSMYEKLGRMM 178
            ||.|||:|..||.|:|:|||:.:|.|::.||||:::|||:.:||||||||:..:|:.|||:|||:
Mouse    66 PPTRKLLAKNLAALYSIGDTYTVFQTLDKCNDIIRSKDDTAAYLPTKLAAVACVGAFYEKMGRML 130

  Fly   179 GRTYEDTVQILIRTLRNAESQARIEIMHTLEKVSAGMGTAIANVHKDIYKAAKHCLLDRVMAVRV 243
            |..:.:||..|:::|::||||.|.||:.:|:||..|:|.|.|:.|:||||.|:..|.||.||||.
Mouse   131 GSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLTGLGGAAASSHRDIYKNARSLLTDRSMAVRC 195

  Fly   244 AAARCILKMIYSAPFLYQTELESLGTLCFRAFDGSNYEVRCAVAQLLGTLLAYTQQLAEAATSKK 308
            |.|:|:|::...|.|::..|||::.||||:|.:.|||.||.||::||||::| |..:.:.||
Mouse   196 AVAKCLLELQNEAVFMWTAELENVATLCFKALENSNYGVRVAVSKLLGTVMA-TALMPKQAT--- 256

  Fly   309 KQGQAVAIQAGKGATQRLVSLDEALGILMSGFLRGGASFLKGTGEIIKGSSGVNREVRVGVTHAY 373
                 |..|..|.||     .||.|.::.:||||||:.|||..||::|....||||||||||.||
Mouse   257 -----VMRQNVKRAT-----FDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAY 311

  Fly   374 VVFVQFMGSVWLERQLSTFLAHVLDLVANPKAACSHVDAVYSRKCISFILRSTIGKMLGEKAQSA 438
            ||||..:|..||||..:|||:||||||::|:|..:||||||||:|:||:||:|:|.:||||||.|
Mouse   312 VVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVDAVYSRRCVSFMLRATVGSLLGEKAQIA 376

  Fly   439 ACKELVHLVAKQMNSI-----DFNPENAKDSNQETLFSQHLLVCALQELSSLLIGLGTTAQNLLG 498
            |.||:...:.|||.::     |.:.|| |....:...|||::|||||||.||:..|..||..|:.
Mouse   377 AAKEICQAIGKQMKAVEAVVNDTSSEN-KSGTADIAASQHVMVCALQELGSLVQSLNATASPLIQ 440

  Fly   499 DQSLQAIDATCAVLVHPCAAARLAAAWCLRCACVAVPGQITPLIDRFVEAIEQMRSSPEAMAGYS 563
            :.|:..::...:||:||..||||||||||||..||:|.|:||.:||..|.:..:::||||::|||
Mouse   441 EASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYS 505

  Fly   564 CALAAILGSVRYSPLGIPHTKGKVVFNCAEELLRSASQNSRMSLHRTQAGWLLIGAIMTLGSPVV 628
            .|:||:||.|...||||||.|||:|.:.||:|||:|:||||:||.||||||||:||:||||..||
Mouse   506 FAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVV 570

  Fly   629 KGLLPRMLLLWRNSFPRSNKELESEKARGDAFTWQVTLEGRAGALSVMHSFLLNCPDLLNEDITR 693
            :..||:|||||||.||||.||||:||||||:||||||||||||||..|.||:.:||:||.||..|
Mouse   571 RYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDAIR 635

  Fly   694 RLLTPIESALAMLVNLASVLKSYGTQLKAPAAMVRLRLFETLTLLPANALEASYTHLLRMLVSEF 758
            :|:||||.|:.|:.::.||:|::|..|||.||||||||::.|.|||....|.|:..|||.||:||
Mouse   636 KLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEF 700

  Fly   759 TLSDNAANTTNSLLRTLCHGDDSIILGTWLQETNHRTIEDQMEPNRKVDGEHLQPNSAAGSGALE 823
            ||:||:||||.||||:|||.|||::||:|||||:|::||||           ||||||:||||||
Mouse   701 TLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQ-----------LQPNSASGSGALE 754

  Fly   824 HDPCCLYRPRSAQGNGSSSNGSSATSTGGSNGGGGSNIQQISKAQQCPGPLPLGVAVIDMAVTLY 888
            |||..:|                               .:|...:..||||||||:|||.:|.|:
Mouse   755 HDPSSIY-------------------------------LRIPAGEAVPGPLPLGVSVIDASVALF 788

  Fly   889 GTIFPKVANKHRLQMLEHFTECIRQAKSSRQEAVQMNIFTALLCALKNLTDSKTSLGQEDVRKSA 953
            |.:||.|:.|||||||:||.||::|||..||:|||:|||||:|.|||.|.::|::||.|:|||||
Mouse   789 GVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSA 853

  Fly   954 TALIVASLTSANSTIRCAAGEALGRLAQVVGDSHFTAELAQNSFDKLKSARDVVTRTGHSHALGC 1018
            ..|::.:|.:.|..:||||||||||:|||||::.|.|.:||.||||||||||||:|||||.||||
Mouse   854 LTLVMGALDNPNPILRCAAGEALGRMAQVVGEASFIARMAQYSFDKLKSARDVVSRTGHSLALGC 918

  Fly  1019 LHRYVGGMGSSQHLSTSVSILLALGQDSASPVVQAWSLYALAQIADSGGPMFRGYVEATLTLCLK 1083
            |||||||:||.|||.|||||||||.||..||.||.|||::||.|.||.|||:|||||.||:|.|.
Mouse   919 LHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLT 983

  Fly  1084 LLLTVPHAHVDVHQCVGRVVNALITTVGPELQGGGGAVATMRGSFLCSAALLQSHSDPLVQAEAI 1148
            ||||||.:|.:||||:||.:.|:||||||||||....::|:|.|.|...|:.|.|||.||||.||
Mouse   984 LLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNAATISTIRSSCLVGCAITQDHSDSLVQAAAI 1048

  Fly  1149 GCLQQLHLFASKSLQLEELVPTLVGMLACNYFILRKASVSCLRQLAHREAKEVCELALTINAEQL 1213
            .||||||:||.:.:.|..|||:|...|..::.:||:|:|:||||||.|||.||||.|::: |:..
Mouse  1049 SCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSL-AKNA 1112

  Fly  1214 PD---------------------------LVITEYGLPGLLFSLLDTETDAEMLRNIHDTLTSML 1251
            .|                           :.||:.||.||||.:||.|||.::..:|||||..||
Mouse  1113 GDKEISGGNVNPFTPGVSSRSDVHCRHQGVNITDTGLEGLLFGMLDRETDRKLCSDIHDTLGHML 1177

  Fly  1252 QMLAADNLSSWLSLCKNVLTVAVEGGLNDDPAAGEQSKSKEAGGEDDEEDEEEEYADDVTEYRAE 1316
            ..||.:.||.||.|||:||..:     :|..||     :..:.|:|:|.::::|..||.......
Mouse  1178 SSLAVEKLSHWLMLCKDVLAAS-----SDMSAA-----TLLSSGKDEESEKKDEMDDDAMFTTLG 1232

  Fly  1317 ENTSTHPAVQPRWPTRVFAAQCVRRIIASCEAASSVHFDLLQAKEQQLIRSRGDYLILHLAELIR 1381
            |...:.|.|.|||.||||||.|:.|||..||.:...||||..|:..:|...:.|.|:|||::|||
Mouse  1233 EEDKSKPFVAPRWATRVFAADCLCRIINLCENSDQAHFDLALARSAKLRNPKNDLLVLHLSDLIR 1297

  Fly  1382 MSFMAATSDSDQLRLEGLRTLQEIIDRFANVPEPEFPGHLLLEQFQAQVGAALRPAFAPDTPSHV 1446
            |:|||||..|:|||:.||:.|::||.:||:|||||||||::|||:||.|||||||||:.||||.:
Mouse  1298 MAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDI 1362

  Fly  1447 TAAACEVCSAWIGSGVARDIGDLKRVHQLLVSSLDKL-SSKTNSTQLYNESMATLEKLSILKAWA 1510
            .|.||:|||.||||||..|:.||:|||.|||||||.: :.|.:|:|||.||..|:|||::|||||
Mouse  1363 IAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDTVQAGKGSSSQLYRESATTMEKLAVLKAWA 1427

  Fly  1511 EVYIVAMIGNGKAPASLLNLQSQQSGFQSLTNLETDSD----VPDSRGESLLGLVQPELHNLSTH 1571
            |||:|||         .:..:::....:::.|.:.|.|    :.:...:||:.||||||..||..
Mouse  1428 EVYVVAM---------NIKKEAESKPKRAMNNPDDDDDDYGTIDELPPDSLITLVQPELPTLSRL 1483

  Fly  1572 WLSAMKDHALLLLPAEFQSQLPHDGGAFYTTDTINSSKPHYMTSWPPILYASALWLRDEGFARHL 1636
            ||:|:||:|||.|||||.||||.|||||||.:||::::.||..||.|||:|.||||...||...
Mouse  1484 WLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFISQ- 1547

  Fly  1637 DTSEAAAES---------NNNQITHGSLSA--------DRFHMIFGICMEALCSMRSSERPRNIV 1684
            :::||...|         :.||:.....||        ||.|:|.|:.::.|||.|..|...::.
Mouse  1548 ESTEATTVSGVQKRSPAVSLNQVPGAMASAKPLPEVNKDRMHLILGVSIQFLCSPRPEEPIEHVT 1612

  Fly  1685 SCLRSLHSIFDSDWARRQLVKDRALTIELCHVLHRQILTRDELLVQLLCVEILKQTIRAAREDLE 1749
            :||::||::..|.:||..:.:|:.:.:||..||||.:||.:...:|||...:::|.:|||::.|:
Mouse  1613 ACLQALHTLLGSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSIQLLVTGVVQQIVRAAQDYLQ 1677

  Fly  1750 RKRDDNA-NSED---------GKGGERHGEDDSMQPGSSHVYAVLEVCLCLFVRQIPTMNPTRQG 1804
            .||  || |.||         |:||:..|    :.||.|.|:|.:|:.:.:.||.:|.::
Mouse  1678 EKR--NALNEEDMEKESCPTLGEGGDTGG----LIPGKSLVFATMELLMFILVRHMPHLS----- 1731

  Fly  1805 AGGSGLQLDFAYAKMATGSSFFSV---LGDENGLLVSSGLQCVEQLMDLCTPKGALAILPTVLYM 1866
                        .||....|..::   |.:|:..||::.:..:..|..||:|.|.:.||||:|::
Mouse  1732 ------------TKMLDSPSHTAMKTQLSEESARLVAATVAILSDLPSLCSPAGCMTILPTILFL 1784

  Fly  1867 TTSIVKEIANKSAIDSTILANTCAVKSALQCLRSVCVHKWAKVEETTEEWQQLLQSALATIVDLT 1931
            ...|:|:.|.||| |:.:   ...|.:|||.::|:.....||.|:|.::|..|::|.||.|::.:
Mouse  1785 IARILKDTAIKSA-DNQV---PPPVSAALQGIKSIVTLSMAKTEDTQKQWTTLIRSTLACILEYS 1845

  Fly  1932 KTAGDNEERKVDEVTMLLAITVFILHTPASVVATPSLQYPCINHFRQCLQSENLSVKLRCIETTR 1996
            :.  |:.....|||:.|.||.:|:....:.::...|||..|:|.|:..|.|.:..|:.:|.:...
Mouse  1846 QP--DDCMPAPDEVSTLTAIALFLWSASSEIIGVQSLQNGCMNRFKSALNSCDPWVQAKCYQLLL 1908

  Fly  1997 SIFARAELKTATPYIHALAPRIIESLYAESSKVPTSELELQVTLESIVTVEQLIDLSEPQNRNMN 2061
            |:|..:....:|||||:|||.::..|.|.....|.|..||....|.|..:|.|:.|.|.|||
Mouse  1909 SVFQHSNRALSTPYIHSLAPLVVGKLKAVERHRPASSTELLAVQEGIKVLETLVALGEEQNR--- 1970

  Fly  2062 LLQDIQMLTLLVPVLIGFLAEPSRLRTLPKYQRQLHDQALQWLLKIGPKYPQEFKALMGQTPELR 2126
                :|:|.||||.||.:|.:.:...:.....:.||:.|||.|:.|||.||..||.:||..|||:
Mouse  1971 ----VQLLALLVPTLISYLLDENSFASASSISKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELK 2031

  Fly  2127 QKLEAAIRSQQQSINIAQKASEAQRNLLAKP-----QKPTIKLKTDF 2168
            .:||.|:|:.|     |.||..|.|    :|     ..|||||||.|
Mouse  2032 ARLETAVRASQ-----ASKAKAAAR----QPAPTTHSTPTIKLKTSF 2069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2747	NP_001262364.1	HEAT repeat	145..173	CDD:293787	15/27 (56%)
		HEAT repeat	185..213	CDD:293787	14/27 (52%)
		HEAT repeat	225..255	CDD:293787	16/29 (55%)
		HEAT repeat	266..292	CDD:293787	14/25 (56%)
		Laa1_Sip1_HTR5	1371..1581	CDD:466361	116/214 (54%)
Heatr5b	NP_001074648.1	HEAT repeat	97..121	CDD:293787	13/23 (57%)
		HEAT repeat	137..165	CDD:293787	14/27 (52%)
		HEAT repeat	177..207	CDD:293787	16/29 (55%)
		HEAT repeat	218..244	CDD:293787	14/25 (56%)
		HEAT 1	848..885		22/36 (61%)
		HEAT repeat	852..882	CDD:293787	16/29 (55%)
		HEAT repeat	891..921	CDD:293787	24/29 (83%)
		HEAT repeat	932..962	CDD:293787	21/29 (72%)
		HEAT 2	1062..1099		18/36 (50%)
		Laa1_Sip1_HTR5	1288..1493	CDD:466361	116/213 (54%)
		HEAT 3	1290..1327		22/36 (61%)