Protein Alignment CG10445 and RAD16

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_009672.1
• Gene: RAD16 / 852411
• SGDID: S000000318
• Length: 790
• Species: Saccharomyces cerevisiae
• Alignment Length: 985
• Identity: 207/985 - (21%)
• Similarity: 384/985 - (38%)
• Gaps: 311/985 - (31%)

  Fly    51 EYADNESAIFVSASEYNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLE 115
            |.:|:::|:      .|.|..|:....:.:  .:.|..:..::|:..|...|     :..:..::
Yeast    23 ELSDDDTAV------KNSKTLQLKGNSENV--NDSQDEEYRDDATLVKSPDD-----DDKDFIID 74

  Fly   116 ALGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNR-----YRQKANHTAA------ 169
            ..|...:.....|:...|| .||.|:::..|:...|:....|.:     .|:|...|:.
Yeast    75 LTGSDKERTATDENTHAIK-NDNDEIIEIKEERDVSDDDEPLTKKRKTTARKKKKKTSTKKKSPK 138

  Fly   170 ---------QFYQHK---SNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQF 222
                     :.|:|.   .|:...||      ...|.:....|||..:.::||..|...|.|:..
Yeast   139 VTPYERNTLRLYEHHPELRNVFTDLK------NAPPYVPQRSKQPDGMTIKLLPFQLEGLHWLIS 197

  Fly   223 RERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKIS 287
            :|....:||:|||:||:|||:..|||::
Yeast   198 QEESIYAGGVLADEMGMGKTIQTIALLM------------------------------------- 225

  Fly   288 MFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEV 352
                                                    ||              |.|:|
Yeast   226 ----------------------------------------ND--------------LTKSP---- 232

  Fly   353 FSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRS 417
                               :|||.|...:.||.:|: .:..:..:::..:||.:| ...|:..:.
Yeast   233 -------------------SLVVAPTVALMQWKNEI-EQHTKGQLKIYIYHGASR-TTDIKDLQG 276

  Fly   418 YDLVITSYNLVVNELKR--YG---------NTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQL 471
            ||:|:|:|.::.:..::  ||         ..|.|..:.:.||||||||.|::.::|...:|..|
Yeast   277 YDVVLTTYAVLESVFRKQNYGFRRKNGLFKQPSVLHNIDFYRVILDEAHNIKDRQSNTARAVNNL 341

  Fly   472 RAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDL---------QQWK----------------- 510
            :....|.|:|||:|||..::::|:||:|:..|...         :.||
Yeast   342 KTQKRWCLSGTPLQNRIGEMYSLIRFLNINPFTKYFCTKCDCASKDWKFTDRMHCDHCSHVIMQH 406

  Fly   511 ---------KNLNE------SMLGHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQ- 559
                     ||:.:      .:.....:..::|.:|||||  |::.:.|:...|    .::.|:
Yeast   407 TNFFNHFMLKNIQKFGVEGPGLESFNNIQTLLKNIMLRRT--KVERADDLGLPP----RIVTVRR 465

  Fly   560 --LSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFL 622
              .::.|..:|:.|...||:.:..|:   |:|....||.:
Yeast   466 DFFNEEEKDLYRSLYTDSKRKYNSFV---EEGVVLNNYAN------------------------- 502

  Fly   623 KSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQ------ 681
                           |..|:.|:||...||.|::..|.. ...:|:..|.....:.|.:
Yeast   503 ---------------IFTLITRMRQLADHPDLVLKRLNN-FPGDDIGVVICQLCNDEAEEPIESK 551

  Fly   682 -----LKMDVLAELDKFDETDSEDDC--CDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPT 739
                 .::.:...::.|.|.:::..|  |          :..|.:                || :
Yeast   552 CHHKFCRLCIKEYVESFMENNNKLTCPVC----------HIGLSI----------------DL-S 589

  Fly   740 ASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTND-KIIVTSQWVSYLAIV 803
            ..:.|..|||.:...:::..|...:: :.|.|::.::::|.:|.:.... |.||.||:.|.|.:|
Yeast   590 QPALEVDLDSFKKQSIVSRLNMSGKW-QSSTKIEALVEELYKLRSNKRTIKSIVFSQFTSMLDLV 653

  Fly   804 RKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHW 868
            ..||:...::|:...|.::..:|:..::.|..|.:..|.|:||.||||.|||..|:.:.|:|..|
Yeast   654 EWRLKRAGFQTVKLQGSMSPTQRDETIKYFMNNIQCEVFLVSLKAGGVALNLCEASQVFILDPWW 718

  Fly   869 NPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGG 933
            ||.:|.|:.||::|.||.:|..|.|:..:|::|.||..||:.|..:....:.::...:::
Yeast   719 NPSVEWQSGDRVHRIGQYRPVKITRFCIEDSIEARIIELQEKKANMIHATINQDEAAISR----- 778

  Fly   934 LNLAELKKLF 943
            |..|:|:.||
Yeast   779 LTPADLQFLF 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	192/897 (21%)
		DEAD-like_helicase_N	209..534	CDD:475120	76/376 (20%)
RAD16	NP_009672.1	HepA	<172..769	CDD:440319	173/790 (22%)
		RING-HC_RAD16-like	536..584	CDD:438229	5/57 (9%)