DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and hltf

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_005163433.1	Gene:	hltf / 564651	ZFINID:	ZDB-GENE-030131-3306	Length:	942	Species:	Danio rerio

Alignment Length:	833	Identity:	207/833 - (24%)
Similarity:	350/833 - (42%)	Gaps:	210/833 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 DSLKTLYEPIQPRPAIDDL------EKQPA-LLLVRLLKHQQSCLKWMQFRER------------ 225
            :.||..::.:     .|||      |.:|| .:...||.||:..|.||..||.
Zfish   195 EELKNAFDKL-----FDDLMEDKTKEMEPAEAVCTPLLSHQKQALSWMSSRENSNDLPPFWEENK 254

  Fly   226 ----------------QKISGGILADDMGLGKTLSMIALILAS-----------------EETKN 257
                            :|:.||||||||||||||:.||||:::                 ...|.
Zfish   255 GLYFNVLTNFAVKKRPEKVLGGILADDMGLGKTLTTIALIVSNFHNGKPLPLEKCKGPSMPSAKR 319

  Fly   258 RKREEKKKALTLKWTQE------FNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKK 316
            ::...|:|.:..:.:||      ..|::...:|         |:|        |:|:|...|.|.
Zfish   320 KQATSKEKGVDSEESQESMGLSPLKRLHDDTVR---------ENG--------PQKKTKTTKKKS 367

  Fly   317 INQFR--ILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMS 379
            .|..:  :|.||...|   |.:|.....::   |..:..........:|.|....| ||:|||:|
Zfish   368 ANTKKAVVLLDDVEFA---AALECSSSQVV---PSKKCVKKSSVPSEISAGSVARA-TLIVCPLS 425

  Fly   380 VMCQWAHEVASKVAQN-AIRVLTFHGPNRHEIGIEAFRSYDLVITSYNLVVNELKRYGN--TSPL 441
            |:..|..:....:..: .::|..::|..|:. .:......|:|:|:||::.::   :||  :|||
Zfish   426 VLSNWLDQFEQHIRTDVTVKVYLYYGSERNR-SVSLLSEQDVVLTTYNVLSSD---FGNKASSPL 486

  Fly   442 FAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDL 506
            ..|.|.||:|||.|::||.......:|.:|::...|.|:|||:||...|:|.||.|:.:..| |:
Zfish   487 HNVKWLRVVLDEGHVVRNPNALQSKAVLELQSERRWILSGTPIQNSLKDLFMLLSFLKLKPF-DV 550

  Fly   507 QQWKKNLNE------SMLGHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEM 565
            ::|...:.:      ..:|.:.|..::|.:.|||||........:..||..::.:..|.||..|.
Zfish   551 KEWWSRIIQRPVTMGDRVGLKNLQALVKGITLRRTKNSKVGGRTLVQLPERRVFVQYVTLSGMER 615

  Fly   566 AVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPG 630
            ..|:.:....|.|..::.   ::|....||..
Zfish   616 EKYERVKGEGKNIVGRYF---QEGTFMANYAD--------------------------------- 644

  Fly   631 EKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDE 695
                   :|.:|:||||.||||.|:     |..||.||..       ...:|:..::.::.....
Zfish   645 -------VLTILMRLRQCCCHPSLV-----GNYTAADVPG-------TPSELRERLIQKITLVLN 690

  Fly   696 TDSEDDCCDEEDSTRR----------------------DGNFKLEVIKDEIKEENVPWDSGDDLP 738
            :.|:::|....||.|:                      ....|..:.:.:||.:.:....|:...
Zfish   691 SGSDEECAICLDSLRQPVITYCAHVFCRPCICEVIRSEKEQAKCPLCRAQIKTKELVEYPGEQAE 755

  Fly   739 TAS-SFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTND----KIIVTSQWVS 798
            |.| :.|:...|::||.|::                       .||...|:    |.:|.||:..
Zfish   756 TRSDTGENWRSSSKALALMS-----------------------NLLKLRNEDPTVKSMVVSQFTG 797

  Fly   799 YLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDF--NANNEKRVLLLSLTAGGVGLNLNVANHM 861
            :|.::...|::..:.....:|.|..:.|...:.||  :......::||||.||||||||..|:.:
Zfish   798 FLDVLEVALREYGFSFTRLDGSLIQRARAKAIEDFQDSTPGSPTIMLLSLKAGGVGLNLTAASQV 862

  Fly   862 LIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEI 914
            .::|..|||..|.|..||.:|.||::...|.:::.:|:||:.:..:|..|.|:
Zfish   863 FVMDPAWNPAAEDQCVDRCHRLGQSRDVVITKFIVKDSVEENMVKIQKKKQEL 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	207/833 (25%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	105/386 (27%)
hltf	XP_005163433.1	HIRAN	59..144	CDD:214906
		SNF2_N	229..662	CDD:278600	129/504 (26%)
		DEXDc	<418..528	CDD:238005	36/113 (32%)
		RING	696..741	CDD:238093	5/44 (11%)
		Helicase_C	767..885	CDD:278689	40/140 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850