Protein Alignment CG10445 and Ercc6l

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001092144.1
• Gene: Ercc6l / 317252
• RGDID: 1565734
• Length: 1230
• Species: Rattus norvegicus
• Alignment Length: 923
• Identity: 199/923 - (21%)
• Similarity: 328/923 - (35%)
• Gaps: 362/923 - (39%)

  Fly    75 QLVQKILTMEQQQRQLEENA--SETKELCDLKLHL---EKLNARLEALGEFLDTLRLREDQQEIK 134
            ||.:..|...|:.::..:|.  .|..:|.:|...:   :|:.:|::.|.|.|:.|...||
  Rat    16 QLAESYLRYSQEAKEAAKNGDLEEALKLFNLAKDIFPTKKVISRIQKLQEALEQLAEEED----- 75

  Fly   135 IEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDDLE 199
                .|..|...        |||..||:                      |||
  Rat    76 ----DEFTDVCN--------SGLLLYRE----------------------LYE------------ 94

  Fly   200 KQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKK 264
                    :|.:||:..:.::....:....|||||||||||||:.:||.:
  Rat    95 --------KLFEHQKEGIAFLYSLYKNGRKGGILADDMGLGKTVQIIAFL--------------- 136

  Fly   265 KALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDND 329
                                 ..|||                       ...:|
  Rat   137 ---------------------SGMFD-----------------------ASLVN----------- 146

  Fly   330 AGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQ 394
                                                     :.|::.|.:::..|..|.|....
  Rat   147 -----------------------------------------HVLLIMPTNLINTWVKEFAKWTP- 169

  Fly   395 NAIRVLTFHGPNRHEIGIEAFRSY-------DLVITSYNLVVNELKRYGNTSPLFAVYWNRVILD 452
             .:||.||||.:::    |..|:.       .:|||:|.:::|..::..:.:.. |..|:.||||
  Rat   170 -GMRVKTFHGSSKN----ERIRNLTRIQQRNGVVITTYQMLLNNWQQLASFNGQ-AFVWDYVILD 228

  Fly   453 EAHIIRNSKTNCCNSVC--QLRAHCHWALTGTPVQNRGVDVFALLRFVNVPN-FQDLQQWKKNLN 514
            |||.|:::.|.  ::||  .:.|.....|||||:||...::::|..|....: ...|:.:|....
  Rat   229 EAHKIKSASTK--SAVCARAVPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYE 291

  Fly   515 ESML---------GHRRLNF--------IIKPLMLRRTKQKL-QASGDMPAL-PSLK---IELIC 557
            ..::         |.:.|.|        ||||..|||||::: ....|.|.: |..|   :|.||
  Rat   292 NPIIRAREKDATPGEKALGFKMSENLMEIIKPYFLRRTKEEVHMKKADKPEVRPGEKNSGVEDIC 356

  Fly   558 VQLS---KTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYE 619
            ..||   |.::.|:..|..:.::|:.:|:             ||:...:.:.     |..:.:.|
  Rat   357 EMLSLTRKNDLIVWIRLVPLQEEIYRKFV-------------SLDHIKELLM-----ETRSPLAE 403

  Fly   620 RFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLM---------IGMLRGALTAEDVQNVKVDA 675
                          ||:        |::.|.||.|:         :|.:  ..:||| :|.:.||
  Rat   404 --------------LGV--------LKKLCDHPRLLSARACHLLNLGTV--TFSAED-ENEQEDA 443

  Fly   676 SDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTA 740
            |:: |.:                                       |.:.:..:..:||
  Rat   444 SNM-GSI---------------------------------------DHLSDNALMQESG------ 462

  Fly   741 SSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMV-IDKLEELLTGTNDKIIVTSQWVSYLAIVR 804
                                            ||: :..|.|.|.....:.:|.||....|.|:.
  Rat   463 --------------------------------KMIFLMALLERLQDEGHQTLVFSQSRQILNIIE 495

  Fly   805 KRLQDLSWETLDFNGQLT-AKEREIVLRDFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHW 868
            :.|::..::||..:|.:| ..|||..::.|..|.|..|.||:...|||||.|..|:.::|.|..|
  Rat   496 RLLKNKHFKTLRIDGTVTHLWEREKRIQLFQQNKEYSVFLLTTQVGGVGLTLTAASRVVIFDPSW 560

  Fly   869 NPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGE---VTKCV 930
            ||..:.||.||:||.||.:...:||.:...|||::|...|..|..:.:....::...   .||
  Rat   561 NPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGDKKNPFRYFTK-- 623

  Fly   931 GGGLNLAELKKLF 943
                  .|||:||
  Rat   624 ------QELKELF 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	183/851 (22%)
		DEAD-like_helicase_N	209..534	CDD:475120	73/351 (21%)
Ercc6l	NP_001092144.1	HepA	<95..612	CDD:440319	166/757 (22%)
		DEXHc_ERCC6L	96..328	CDD:350759	73/351 (21%)