Protein Alignment CG10445 and rhp16

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_587701.1
• Gene: rhp16 / 2538860
• PomBaseID: SPCC330.01C
• Length: 963
• Species: Schizosaccharomyces pombe
• Alignment Length: 1022
• Identity: 223/1022 - (21%)
• Similarity: 382/1022 - (37%)
• Gaps: 324/1022 - (31%)

  Fly    15 QSCSIQDQSSVP---VPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVSASEYNEKKAQIDQL 76
            ||.:...|.|.|   :.|:|....:     ..|::|.      |.:..|.||   .::..:...|
pombe   171 QSNNTSSQHSTPPLSISDTSTHTGS-----STDNVEA------NPNTGFSSA---RKRSLRSSNL 221

  Fly    77 VQKILTMEQQQRQLE------ENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQEIKI 135
            .:|.:.:...:...|      :.:.|...:.|:| ..|..::::| :.|...:.....|::.|.:
pombe   222 KKKFVPLSSPEESNESEFIDDDESDEVASIIDIK-EDETFDSKVE-IPEAAPSSSTESDEESIPL 284

  Fly   136 EDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDS-LKTLYEPIQPRPAIDDL- 198
            ...|:                ..|...:|:.:|:...:.::..|.| .:|.|..|:..|.::.:
pombe   285 SYQSK----------------RRRVSARASSSASSSSRTQAKSIPSHERTHYRLIRQHPELEHVW 333

  Fly   199 EK-------------QPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALIL 250
            ||             ||..|::.||..|:..:.|::.:|.....||||||:||:|||:..|||:|
pombe   334 EKLEEEAPREVKQIEQPKELVLNLLPFQREGVYWLKRQEDSSFGGGILADEMGMGKTIQTIALLL 398

  Fly   251 ASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTK 315
            :                                         |..||.
pombe   399 S-----------------------------------------EPRGKP----------------- 405

  Fly   316 KINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSV 380
                                                                    ||||.|:..
pombe   406 --------------------------------------------------------TLVVAPVVA 414

  Fly   381 MCQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRSYDLVITSYNLV--VNELKRYG------- 436
            :.||..|:.:. ...|:....::|..| :|..|...|||:|:||||::  |...:|.|
pombe   415 IMQWKEEIDTH-TNKALSTYLYYGQAR-DISGEELSSYDVVLTSYNVIESVYRKERSGFRRKNGV 477

  Fly   437 --NTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVN 499
              ..|.|..:.:.|:||||||.|::...|...:||.||......|:|||:|||..::|:||||:.
pombe   478 VKEKSLLHQMEFYRIILDEAHGIKSRTCNTARAVCGLRTTRKICLSGTPLQNRIGELFSLLRFLR 542

  Fly   500 VPNF---QDLQ------QW----KKNLNE----------------------------SMLGHRRL 523
            ...|   ..||      .|    :.|.:|                            ..|..:::
pombe   543 ADPFAYYYCLQCECKSLHWRFSDRSNCDECGHKPMSHTCYFNAEMLKPIQKFGYEGPGKLAFKKV 607

  Fly   524 NFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREK 588
            :.::|.:|||||  ||:.:.|: .||...:|:.....::.|..|||.|...||:.|..:|.:
pombe   608 HSLLKHIMLRRT--KLERADDL-GLPPRVVEVRKDLFNEEEEDVYQSLYMDSKRKFNTYLAE--- 666

  Fly   589 GNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPG 653
             ...||.|:                                       .|..|:.|:||...||.
pombe   667 -GVVLNNYA---------------------------------------NIFQLITRMRQMADHPD 691

  Fly   654 LMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDD------CCDEEDSTRRD 712
            |::...|..:..|:.:|:.....|...|            |..:|...      |..|..:...|
pombe   692 LVLASKRKTVDIENQENIVCKICDEVAQ------------DAIESRCHHTFCRLCVTEYINAAGD 744

  Fly   713 GNFKLEVIKDEIKEENV-------PWDSGDDLPTASSF-EDQLDSARALKLLNPQNPIFQFIRPS 769
            |             |||       |.......|....| |::..:|..|..::..:     .|.|
pombe   745 G-------------ENVNCPSCFIPLSIDLSAPALEDFSEEKFKNASILNRIDMNS-----WRSS 791

  Fly   770 AKLKMVIDKLEELLTGTND---KIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLR 831
            .|::.::::|  .|....|   |.||.||:.|.|.::..||:...:..:..:|.:|.|.|...:.
pombe   792 TKIEALVEEL--YLLRKKDRTLKSIVFSQFTSMLDLIHWRLRKAGFNCVKLDGGMTPKARAATIE 854

  Fly   832 DFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMC 896
            .|:.:....:.|:||.||||.|||..|:.:.::|..||..::.||.|||:|.||.:|..:.....
pombe   855 AFSNDINITIFLVSLKAGGVALNLTEASQVFMMDPWWNGAVQWQAMDRIHRIGQKRPIKVITLCI 919

  Fly   897 QDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLF 943
            ::::|.:|..||:.|.::....:.::...:.:     |::.:::.||
pombe   920 ENSIESKIIELQEKKAQMIHATIDQDEKALNQ-----LSVEDMQFLF 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	200/889 (22%)
		DEAD-like_helicase_N	209..534	CDD:475120	84/376 (22%)
rhp16	NP_587701.1	HepA	<319..943	CDD:440319	189/817 (23%)
		RING-HC_RAD16-like	709..757	CDD:438229	11/72 (15%)