DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and rhp16

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_587701.1	Gene:	rhp16 / 2538860	PomBaseID:	SPCC330.01c	Length:	963	Species:	Schizosaccharomyces pombe

Alignment Length:	1022	Identity:	223/1022 - (21%)
Similarity:	382/1022 - (37%)	Gaps:	324/1022 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QSCSIQDQSSVP---VPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVSASEYNEKKAQIDQL 76
            ||.:...|.|.|   :.|:|....:     ..|::|.      |.:..|.||   .::..:...|
pombe   171 QSNNTSSQHSTPPLSISDTSTHTGS-----STDNVEA------NPNTGFSSA---RKRSLRSSNL 221

  Fly    77 VQKILTMEQQQRQLE------ENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQEIKI 135
            .:|.:.:...:...|      :.:.|...:.|:| ..|..::::| :.|...:.....|::.|.:
pombe   222 KKKFVPLSSPEESNESEFIDDDESDEVASIIDIK-EDETFDSKVE-IPEAAPSSSTESDEESIPL 284

  Fly   136 EDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDS-LKTLYEPIQPRPAIDDL- 198
            ...|:                ..|...:|:.:|:...:.::..|.| .:|.|..|:..|.::.:
pombe   285 SYQSK----------------RRRVSARASSSASSSSRTQAKSIPSHERTHYRLIRQHPELEHVW 333

  Fly   199 EK-------------QPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALIL 250
            ||             ||..|::.||..|:..:.|::.:|.....||||||:||:|||:..|||:|
pombe   334 EKLEEEAPREVKQIEQPKELVLNLLPFQREGVYWLKRQEDSSFGGGILADEMGMGKTIQTIALLL 398

  Fly   251 ASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTK 315
            :                                         |..||.
pombe   399 S-----------------------------------------EPRGKP----------------- 405

  Fly   316 KINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSV 380
                                                                    ||||.|:..
pombe   406 --------------------------------------------------------TLVVAPVVA 414

  Fly   381 MCQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRSYDLVITSYNLV--VNELKRYG------- 436
            :.||..|:.:. ...|:....::|..| :|..|...|||:|:||||::  |...:|.|
pombe   415 IMQWKEEIDTH-TNKALSTYLYYGQAR-DISGEELSSYDVVLTSYNVIESVYRKERSGFRRKNGV 477

  Fly   437 --NTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVN 499
              ..|.|..:.:.|:||||||.|::...|...:||.||......|:|||:|||..::|:||||:.
pombe   478 VKEKSLLHQMEFYRIILDEAHGIKSRTCNTARAVCGLRTTRKICLSGTPLQNRIGELFSLLRFLR 542

  Fly   500 VPNF---QDLQ------QW----KKNLNE----------------------------SMLGHRRL 523
            ...|   ..||      .|    :.|.:|                            ..|..:::
pombe   543 ADPFAYYYCLQCECKSLHWRFSDRSNCDECGHKPMSHTCYFNAEMLKPIQKFGYEGPGKLAFKKV 607

  Fly   524 NFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREK 588
            :.::|.:|||||  ||:.:.|: .||...:|:.....::.|..|||.|...||:.|..:|.:
pombe   608 HSLLKHIMLRRT--KLERADDL-GLPPRVVEVRKDLFNEEEEDVYQSLYMDSKRKFNTYLAE--- 666

  Fly   589 GNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPG 653
             ...||.|:                                       .|..|:.|:||...||.
pombe   667 -GVVLNNYA---------------------------------------NIFQLITRMRQMADHPD 691

  Fly   654 LMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDD------CCDEEDSTRRD 712
            |::...|..:..|:.:|:.....|...|            |..:|...      |..|..:...|
pombe   692 LVLASKRKTVDIENQENIVCKICDEVAQ------------DAIESRCHHTFCRLCVTEYINAAGD 744

  Fly   713 GNFKLEVIKDEIKEENV-------PWDSGDDLPTASSF-EDQLDSARALKLLNPQNPIFQFIRPS 769
            |             |||       |.......|....| |::..:|..|..::..:     .|.|
pombe   745 G-------------ENVNCPSCFIPLSIDLSAPALEDFSEEKFKNASILNRIDMNS-----WRSS 791

  Fly   770 AKLKMVIDKLEELLTGTND---KIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLR 831
            .|::.::::|  .|....|   |.||.||:.|.|.::..||:...:..:..:|.:|.|.|...:.
pombe   792 TKIEALVEEL--YLLRKKDRTLKSIVFSQFTSMLDLIHWRLRKAGFNCVKLDGGMTPKARAATIE 854

  Fly   832 DFNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMC 896
            .|:.:....:.|:||.||||.|||..|:.:.::|..||..::.||.|||:|.||.:|..:.....
pombe   855 AFSNDINITIFLVSLKAGGVALNLTEASQVFMMDPWWNGAVQWQAMDRIHRIGQKRPIKVITLCI 919

  Fly   897 QDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKLF 943
            ::::|.:|..||:.|.::....:.::...:.:     |::.:::.||
pombe   920 ENSIESKIIELQEKKAQMIHATIDQDEKALNQ-----LSVEDMQFLF 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	208/944 (22%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	84/376 (22%)
rhp16	NP_587701.1	HepA	27..962	CDD:223627	223/1022 (22%)
		DEXDc	378..526	CDD:238005	59/263 (22%)
		RING	711..753	CDD:214546	11/66 (17%)
		Helicase_C	791..907	CDD:278689	39/117 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		otm47368
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840