Protein Alignment CG10445 and Hltf

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_033236.2
• Gene: Hltf / 20585
• MGIID: 1196437
• Length: 1003
• Species: Mus musculus
• Alignment Length: 1035
• Identity: 257/1035 - (24%)
• Similarity: 421/1035 - (40%)
• Gaps: 270/1035 - (26%)

  Fly    13 HKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVSASEY--NEKKAQIDQ 75
            :.:..::|.:.:.|...::.::||           ::|....:......:|..|  :.|.||::.
Mouse    79 NNEMVALQREPNNPYDKNAIKVNN-----------VNGNQVGHIKREIAAAVAYIMDNKLAQVEG 132

  Fly    76 LV----QKILTMEQQQR--QLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQEIK 134
            :|    ....||.....  ..|||.:...|  .||.|..||....:.||..|:.
Mouse   133 VVPFGASNTFTMPLYMTFWGKEENRNVVLE--QLKKHGFKLGPTPKTLGSSLEN----------- 184

  Fly   135 IEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDD-- 197
                          .|.:..:|.: |.:.| |.|.|.      ..|.|||.::.:......||
Mouse   185 --------------AWGSGRAGPS-YSRPA-HVAVQM------TTDQLKTEFDKLFEDLKEDDRT 227

  Fly   198 LEKQPA-LLLVRLLKHQQSCLKWMQFRERQK----------------------------ISGGIL 233
            :|.:|| .:...||.||:..|.||..||..|                            :.||||
Mouse   228 VEMEPAEAIETPLLPHQKQALAWMIARENSKELPPFWEQRNDLYYNTITNFSVKERPENVHGGIL 292

  Fly   234 ADDMGLGKTLSMIALILAS----------------------EETKNR------KREE-------- 262
            ||||||||||:.||:||.:                      :||..|      |:|:
Mouse   293 ADDMGLGKTLTAIAVILTNFDDGRPLLSKRGKKNHPGKEYKDETIKRRGSNMDKKEDGHSESSTC 357

  Fly   263 ----------KKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKI 317
                      :|.:.||   .:.:.| |.:.||||:...|....:|.|..|.|:|....:|..::
Mouse   358 GEEPSISGTPEKSSCTL---SQLSSV-CPKRRKISVQYIESSDSEEIETSELPQKMKGKLKNVQL 418

  Fly   318 N-QFRILDDDDNDAGDKAVVEDE-----------QKDLLAKTPEPEVFSSDEEEEHLSNGRYPSA 370
            | :.|:       .|...|.||.           |:.:|.|.     .|..|..|....|....|
Mouse   419 NTKSRV-------KGSSKVKEDSKFALTFFASATQRKMLKKG-----MSMMECSEACDTGERTRA 471

  Fly   371 NTLVVCPMSVMCQWAHEVASKVAQNA-IRVLTFHGPNRHEIGIEAFRS-YDLVITSYNLVVNELK 433
             ||::||:||:..|..:....|.... :....::||:|  |...|:.| .|:::|:||::.::
Mouse   472 -TLIICPLSVLSNWIDQFGQHVKSEVHLNFYVYYGPDR--IRDSAWLSKQDIILTTYNILTHD-- 531

  Fly   434 RYG--NTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLR 496
             ||  :.|||.::.|.||||||.|.|||.......:|.:|.|...|.|||||:||...|:::||.
Mouse   532 -YGTKDDSPLHSIKWLRVILDEGHAIRNPNAQQTKAVLELEAERRWVLTGTPIQNSLKDLWSLLS 595

  Fly   497 FVNVPNFQDLQQWKKNLNESML-----GHRRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELI 556
            |:.:..|.|.:.|.:.:...:.     |.|||..:||.:.|||||........:..||..|:.:.
Mouse   596 FLKLKPFIDREWWYRIIQRPVTTGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQ 660

  Fly   557 CVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERF 621
            .:.||:.|..:||.:              :.:|.:.:..|..|.|   :..|.:|
Mouse   661 HITLSEEERKIYQSV--------------KNEGKAAIGRYFTEGT---VLAHYAD---------- 698

  Fly   622 LKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDV 686
                            :|.|||||||.|||..|:         ...:.:.....||...:|:..:
Mouse   699 ----------------VLGLLLRLRQICCHTHLL---------TNGMSSSGPSRSDTPEELRKML 738

  Fly   687 LAELDKFDETDSEDDCCDEEDST----------------------RRDGNFKLEVIKDEIKEENV 729
            :.::.....:.|:::|....||.                      ....:.|..:.::||..:|:
Mouse   739 IEKMKIILSSGSDEECAICLDSLTFPVITHCAHVFCKPCICQVIHSEQPHAKCPLCRNEIHGDNL 803

  Fly   730 PWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLT-GTNDKIIVT 793
            .....::|...|..|..::                 .:.|:|:..::..|.||.| ..|.|.:|.
Mouse   804 LECPPEELACDSDKESSME-----------------WKSSSKINALMHALIELRTKDPNIKSLVV 851

  Fly   794 SQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNE---KRVLLLSLTAGGVGLNL 855
            ||:.::|:::...|:...:.....:|.:..|:|...::.|. |.|   ..::||||.||||||||
Mouse   852 SQFTTFLSLIETPLKASGFVFTRLDGSMAQKKRVESIQRFQ-NTEAGSPTIMLLSLKAGGVGLNL 915

  Fly   856 NVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIA 915
            ..|:.:.::|..|||..|.|..||.:|.||.:...|.:::.:|:||:.:..:|:.|.::|
Mouse   916 CAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNTKRDLA 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	235/927 (25%)
		DEAD-like_helicase_N	209..534	CDD:475120	122/419 (29%)
Hltf	NP_033236.2	DNA-binding. /evidence=ECO:0000250	38..287		51/253 (20%)
		HIRAN	60..153	CDD:400928	13/84 (15%)
		DEXHc_HLTF1_SMARC3	240..638	CDD:350829	122/419 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..373		6/55 (11%)
		HepA	<468..980	CDD:440319	154/584 (26%)
		DEGH box	551..554		2/2 (100%)
		RING-HC_HLTF	749..803	CDD:438172	7/53 (13%)
		Interaction with SP1 and SP3. /evidence=ECO:0000250	919..1003		18/57 (32%)