DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10445 and csb-1

DIOPT Version :9

Sequence 1:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_510607.2	Gene:	csb-1 / 181674	WormBaseID:	WBGene00000803	Length:	957	Species:	Caenorhabditis elegans

Alignment Length:	1008	Identity:	195/1008 - (19%)
Similarity:	345/1008 - (34%)	Gaps:	390/1008 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESSSPSDTTEIHKQSCSIQDQSSVPVPD----------------SSGEINNWMEPEPVDSLELSG 50
            |..:|...|   .::.|:.|...|.:.|                ||.:.:...|||..:.
Worm     6 EPENPDSGT---PKTLSVDDDDIVVIEDQNTPKYREAALRRSNSSSSDFDEKWEPELDEE----- 62

  Fly    51 EYADNESAIFV----SASEYNEKKAQIDQLV--------QKILTMEQQQRQLEENASETKELCDL 103
            ::.:|::.:..    |.|....:::...:.|        ::...:|:.:::..::.|.::...|
Worm    63 DFCENDADVLAEPISSKSRKKSRRSDSSEFVPSEESDDDEEYEVLEKSRKKGRKSGSSSRSSSD- 126

  Fly   104 KLHLEKLNARLEALGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKANHTA 168
                           :|:::    :|.::.|   ::.|:|..:.   .|..:.:::.:.:|.
Worm   127 ---------------DFIES----DDNEDYK---SAGLLDDNDS---KNFKARIDKLKPEAT--- 163

  Fly   169 AQFYQHKSNIIDSLKTLYEPI--QPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGG 231
                   |.::|:.....|..  ..:|     .|..|.:..:|.|.||..::|:| ::....|||
Worm   164 -------SELVDTRMVTSEEYGKSSKP-----WKVNAGVWNKLHKFQQEGVEWLQ-KKTDHRSGG 215

  Fly   232 ILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESG 296
            ||||:||||||:..:..:.:.:||
Worm   216 ILADEMGLGKTIQSVVFLRSIQET----------------------------------------- 239

  Fly   297 KEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEH 361
                      .|| |.||..::
Worm   240 ----------ART-HYKTTGLD------------------------------------------- 250

  Fly   362 LSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFH---GPNRHEIGIEAFRSYD---- 419
                     ..|:||.:|::.||..|:.....:..:.:|..|   |.....:| ..||...
Worm   251 ---------TALIVCHVSIIAQWIKELNQWFPKARVFLLHSHCSTGRQEDYVG-SIFRKLQRRRK 305

  Fly   420 ------LVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWA 478
                  :::|:|:| ..:||:     |:....|..|||||.|.|||..|.|..::.:|.....:.
Worm   306 EYPDGAIILTTYSL-FTKLKK-----PIVKHLWQVVILDEGHYIRNENTKCSIAMRKLMTTQRFI 364

  Fly   479 LTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNLNESMLGHRRLN-----------------FI 526
            |||||.|||..:.:.|:.||:.....|...:.:|....:.....||                 ..
Worm   365 LTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANLNCSPEAAAKAYECLVALHIA 429

  Fly   527 IKPLMLRRT----KQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQRE 587
            :|||:|||.    |:.||       ||..:..::..:|||.:..:|.                 |
Worm   430 VKPLILRRLQEDHKEVLQ-------LPEKQEIVLSCELSKRQRRLYM-----------------E 470

  Fly   588 KGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKS-LGYNPGEKILGIYILVLLLRLRQFCCH 651
            .|||                    .:.|||.||.||: :|.|               .|...|.|
Worm   471 YGNS--------------------HQVNEIIERRLKAFVGIN---------------HLTNICNH 500

  Fly   652 PGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFK 716
            ||:
Worm   501 PGI-------------------------------------------------------------- 503

  Fly   717 LEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEE 781
                                                .:.|:|.:|.|..|:.|.|::|.....::
Worm   504 ------------------------------------YRSLSPASPKFGSIKDSGKVEMTFKLFDD 532

  Fly   782 LLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKRVLLLSL 846
            ......:::|:.:|..:.:.::...|.:...:.:...|..:|..|..:::.|..:...:|.|::.
Worm   533 WFKSPTNRVILFTQRRTVITMMEYFLAEKGIKCVSLTGADSAAARPKIIKKFEDDVSIKVFLMTT 597

  Fly   847 TAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVE--QRIKSLQD 909
            .|||:||||..||.::|.|..||||.:.||::||||.|||....|||.:...|:|  :..|.:|
Worm   598 RAGGLGLNLTCANKVIIFDPDWNPQADNQAKNRIYRMGQTNDVAIYRLVSNGTIEDLKFFKQVQ- 661

  Fly   910 CKLEIAKVVLPEEGGEVTKCVGGGLNLAELKKL 942
             |..:|..:|  ...|:.:.|... .||:|.:|
Worm   662 -KENLAARLL--HNAEIDQFVPNN-TLADLFRL 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	178/892 (20%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	77/354 (22%)
csb-1	NP_510607.2	SNF2_N	197..503	CDD:278600	103/476 (22%)
		DEXDc	213..369	CDD:238005	55/266 (21%)
		Helicase_C	520..635	CDD:278689	33/114 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000