Protein Alignment CG10445 and ercc6l

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_002936822.1
• Gene: ercc6l / 100135235
• XenbaseID: XB-GENE-988849
• Length: 1361
• Species: Xenopus tropicalis
• Alignment Length: 964
• Identity: 203/964 - (21%)
• Similarity: 314/964 - (32%)
• Gaps: 408/964 - (42%)

  Fly    38 MEPEPVDSLELSGEYADNESA---------IFVSASEYNEKKAQIDQLVQKILTMEQQQRQLEEN 93
            :|||.|:..||..:.|..|:.         .||.|||.:..
 Frog    22 VEPEQVERYELYVKKAKQEATSGNLEKAIKFFVKASEIHPS------------------------ 62

  Fly    94 ASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQEIKIEDNSELVDHTEQPKWSNLYSGLN 158
                          :|::.|:|.|.|.|:.|.|:||..:       :.||        .|.|||.
 Frog    63 --------------DKIHRRIEKLKEALEELDLQEDADD-------DFVD--------VLNSGLT 98

  Fly   159 RYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKWMQFR 223
            .|.:..|    :.::|:...:..|.:||                                    |
 Frog    99 IYNELYN----KLFEHQKEGVAFLYSLY------------------------------------R 123

  Fly   224 ERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISM 288
            :.:|  |||||||||||||:.:|..:                                    ..|
 Frog   124 DGRK--GGILADDMGLGKTIQVIGFL------------------------------------SGM 150

  Fly   289 FDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVF 353
            ||.|                                                   |.|
 Frog   151 FDSE---------------------------------------------------LIK------- 157

  Fly   354 SSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHE--IGIEAF- 415
                             ..|:|.|.:::..|..|......  .:||..|||.::.|  ..:|..
 Frog   158 -----------------YVLLVMPTTLISNWVKEFQKWTP--GLRVAEFHGTSKKERTRNLEKIQ 203

  Fly   416 RSYDLVITSYNLVVNELKRYGNTSPLFAVY------WNRVILDEAHIIRNSKTNCCNSVCQLRAH 474
            |...::||:|.:::|..::       .|.|      |:.:||||||.|:.|.|....|...:.|.
 Frog   204 RMSGIIITTYQMLINNWQQ-------LATYNGREFEWDYIILDEAHKIKTSSTKTAKSCHSIPAK 261

  Fly   475 CHWALTGTPVQNRGVDVFALLRF--------------------VNVPNFQDLQQWKKNLNESMLG 519
            ....|||||:||...:::||..|                    :.....:|....:|.|...:
 Frog   262 NRILLTGTPIQNNLREMWALYDFACQGTLLGTSKTFKMEYENPITRAREKDATPGEKALGLKI-- 324

  Fly   520 HRRLNFIIKPLMLRRTKQ----------KLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAI 574
            ...|..||:|..|||||.          :.|.:...|::|||        ..|.:..|:..||.|
 Frog   325 SENLMKIIQPYFLRRTKSDVQNKKTERTRAQDTSQGPSMPSL--------TRKNDFIVWVYLSTI 381

  Fly   575 SKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYIL 639
            .:.::.:|:             ||::..:.:....|.                           |
 Frog   382 QEDVYRKFI-------------SLDQIKELLMTTRSP---------------------------L 406

  Fly   640 VLLLRLRQFCCHPGLMI--GMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDC 702
            ..|..|::.|.||.|:.  ..::..|..:|..      |:.||..::     :.|||.
 Frog   407 AELNILKKLCDHPRLLSARACIQLGLEGDDYH------SNEEGDHEL-----VTKFDH------- 453

  Fly   703 CDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIR 767
                             :.|||                                        .|.
 Frog   454 -----------------LSDEI----------------------------------------LIE 461

  Fly   768 PSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRD 832
            .|.||.::||.|.: |.....:.:|.||....|.::.:.||:.:::.:..:|.:...|||..:..
 Frog   462 ESGKLLLLIDLLHK-LKEEGHRTLVFSQSRKMLDMIDRILQNKNFKVMRIDGTVALPEREKRISI 525

  Fly   833 FNANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQ 897
            |.:||...||||:...|||||.|..|:.::|.|..|||..:.||.||.||.||.:...|||.:..
 Frog   526 FQSNNNYSVLLLTTQVGGVGLTLTAADRVVIFDPSWNPATDAQAVDRAYRIGQQENVVIYRLITC 590

  Fly   898 DTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLN------LAELKKLFEM 945
            .|||::|...|..|..:           :.:..|...|      ..|||:||.:
 Frog   591 GTVEEKIYRRQIFKESL-----------IRQTTGDKKNPFRYFSKQELKELFSL 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	182/846 (22%)
		DEAD-like_helicase_N	209..534	CDD:475120	71/353 (20%)
ercc6l	XP_002936822.1	LapB	<21..123	CDD:442196	35/193 (18%)
		HepA	<106..613	CDD:440319	165/801 (21%)
		DEXHc_ERCC6L	107..339	CDD:350759	75/391 (19%)
		MPH1	<482..753	CDD:440728	53/163 (33%)
		Spy	1305..>1359	CDD:443119