Protein Alignment CG10445 and ercc6l

DIOPT Version :10

• Sequence 1: NP_649751.2
• Gene: CG10445 / 40938
• FlyBaseID: FBgn0037531
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001093563.2
• Gene: ercc6l / 100005291
• ZFINID: ZDB-GENE-060531-56
• Length: 1444
• Species: Danio rerio
• Alignment Length: 943
• Identity: 202/943 - (21%)
• Similarity: 311/943 - (32%)
• Gaps: 384/943 - (40%)

  Fly    68 EKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKLHL---EKLNARLEALGEFLDTLRLRED 129
            ||..:.|:..||     .::..|........||..|...|   |||..|::|:.:.:.    |||
Zfish    22 EKMGKYDRYRQK-----GKEAALNGELPHALELFQLAYQLQPSEKLKKRIQAIQDLIQ----RED 77

  Fly   130 QQEIKIEDNSELVDHTEQPKWSNL-YSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRP 193
            ::           |..|:.::.|: .|||..|                      |.||:
Zfish    78 EE-----------DEEEEEEFVNVNNSGLKLY----------------------KGLYD------ 103

  Fly   194 AIDDLEKQPALLLVRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNR 258
                          :|..||:..:.::....|....|||||||||||||:.:|:.:
Zfish   104 --------------KLYDHQKEGVAFLYSLYRDGRKGGILADDMGLGKTIQVISFL--------- 145

  Fly   259 KREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRIL 323
                                       ..|:|.|
Zfish   146 ---------------------------SGMYDAE------------------------------- 152

  Fly   324 DDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHEV 388
                                                  |:|      :||:|.|.|::..|..|.
Zfish   153 --------------------------------------LAN------HTLLVMPTSLIKNWVREF 173

  Fly   389 ASKVAQNAIRVLTFHGPNRHE--IGIEAF-RSYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVI 450
            |....  .:||..|||.::.|  ..:|.. |...::||:|.:::|..::.|:.... ...|:.||
Zfish   174 AKWTP--GMRVKEFHGSSKTERNRNLERIQRKGGVIITTYQMLINNYEQLGSNGHR-EFKWDYVI 235

  Fly   451 LDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKK---- 511
            |||||.|:.|.|....|...:.|.....||||||||...:::||..|....:.....:..|
Zfish   236 LDEAHKIKTSSTKTAKSAHAIPAKNRVLLTGTPVQNNLREMWALFDFACQGSLLGTSKTFKTEYE 300

  Fly   512 -----------NLNESMLGHR---RLNFIIKPLMLRRTKQKLQASG------------------- 543
                       ...|..||.|   .|..||||..|||||..:|...
Zfish   301 NPITRAREKDATPGEKALGLRISQNLTDIIKPYFLRRTKADVQQKKLKLEEGFEEEEDQENKCPN 365

  Fly   544 -----DMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQ 603
                 :||:|           ..|.::.|:..||::.:.|:.:|:             ||::..:
Zfish   366 AREGVEMPSL-----------TRKNDLIVWTYLSSVQEDIYNKFI-------------SLDQIKE 406

  Fly   604 FIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLM-------IGMLRG 661
            .:....|.                           |..|..|::.|.||.|:       :|:.||
Zfish   407 LLTTTRSP---------------------------LAELTVLKKLCDHPRLLSQRAVIQLGLERG 444

  Fly   662 ALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKE 726
                                              :|||....||.:|.
Zfish   445 ----------------------------------SDSELVHSDESESA----------------- 458

  Fly   727 ENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKII 791
                             ..|:|:.....|          |..|.||:.|: .|.|.|.....:.:
Zfish   459 -----------------VSQIDNISDHTL----------IEESGKLQFVV-SLMECLREEGHRTL 495

  Fly   792 VTSQWVSYLAIVRKRLQDLSWETLDFNG---QLTAKEREIVLRDFNANNEKRVLLLSLTAGGVGL 853
            :.||....|.|:.:.|::.::..|..:|   ||..:|:.|.|  |..:....:.||:...||||:
Zfish   496 IFSQSRKMLDIMERVLRNRNFRLLRLDGTVTQLAEREKRISL--FQTDKRYTIFLLTTQVGGVGI 558

  Fly   854 NLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVV 918
            .|..||.::|.|..|||..:.||.||.||.|||:...|||.:...|||::|...|..|..:
Zfish   559 TLTGANRVVIFDPSWNPATDAQAVDRAYRIGQTENVIIYRLITCGTVEEKIYRRQVFKDSL---- 619

  Fly   919 LPEEGGEVTKCVGGGLN------LAELKKLFEM 945
                   :.:..|...|      ..||::||::
Zfish   620 -------IRQTTGDKKNPFRYFSKQELRELFKL 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10445	NP_649751.2	HepA	<113..919	CDD:440319	183/861 (21%)
		DEAD-like_helicase_N	209..534	CDD:475120	79/345 (23%)
ercc6l	NP_001093563.2	TPR 1	27..60		8/37 (22%)
		DEAH box	237..240		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	647..669
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..804
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..999
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1028..1047
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1056..1076
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1089..1133
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1175..1336
		TPR 2	1395..1428