DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2616 and MTM1

DIOPT Version :9

Sequence 1:	NP_001287212.1	Gene:	CG2616 / 40915	FlyBaseID:	FBgn0037512	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_011773.3	Gene:	MTM1 / 853173	SGDID:	S000003489	Length:	366	Species:	Saccharomyces cerevisiae

Alignment Length:	371	Identity:	113/371 - (30%)
Similarity:	181/371 - (48%)	Gaps:	65/371 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 QQVISACTGAMITACFMTPLDVIKTRMQSQQS-PAHKC-------FFYSNGLMDHLFAS--GPN- 145
            ::::||..|:::|:..:||:||::.|:|.||. |...|       ...|:|.....|.:  |.|
Yeast    14 ERMLSAGAGSVLTSLILTPMDVVRIRLQQQQMIPDCSCDGAAEVPNAVSSGSKMKTFTNVGGQNL 78

  Fly   146 -----------GSELASLRQRPQFSSSWDALMKISRHEGLAALWSGLGPTLVSALPSTIIYFVAY 199
                       ..||.......:|:.:.:|..||:..||:.:||.|:..||:.|:|:.::||..|
Yeast    79 NNAKIFWESACFQELHCKNSSLKFNGTLEAFTKIASVEGITSLWRGISLTLLMAIPANMVYFSGY 143

  Fly   200 EQFKARYLQIYESHYNKSQEPRHLEIRDTKKSLPSVVPMMSGVTARICAVTVVSPIELVRTKMQA 264
            |..:                    ::.....:.|::.|:..|..||:.|.|.::|:|||:||:|:
Yeast   144 EYIR--------------------DVSPIASTYPTLNPLFCGAIARVFAATSIAPLELVKTKLQS 188

  Fly   265 ------QRQTY---AQMLQFVRSVVALQG-VWGLWRGLRPTILRDVPFSGIYWPIYESLKQNLGH 319
                  ..:|:   ..:|...|..:.:.| ...|::||..|:.||||||.|||..||..|:.|..
Yeast   189 IPRSSKSTKTWMMVKDLLNETRQEMKMVGPSRALFKGLEITLWRDVPFSAIYWSSYELCKERLWL 253

  Fly   320 GSQ---------PSFSLSFLAGVMAGTVAAIVTTPFDVVKTHEQIEFGERVIFTDSPARDFGKKS 375
            .|.         ..|..||.:|.::|.:|||.|.||||.||..||.    ::....|......::
Yeast   254 DSTRFASKDANWVHFINSFASGCISGMIAAICTHPFDVGKTRWQIS----MMNNSDPKGGNRSRN 314

  Fly   376 TFSRLTGIYRTHGVRGLFAGCGPRLLKVAPACAIMISTFEYSKSFF 421
            .|..|..|:||.|:..|:.|...|::|:.|:||||||::|.||..|
Yeast   315 MFKFLETIWRTEGLAALYTGLAARVIKIRPSCAIMISSYEISKKVF 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2616	NP_001287212.1	Mito_carr	86..207	CDD:278578	38/136 (28%)
		Mito_carr	230..321	CDD:278578	35/100 (35%)
		Mito_carr	321..425	CDD:278578	40/110 (36%)
MTM1	NP_011773.3	Mito_carr	14..149	CDD:278578	38/154 (25%)
		Mito_carr	154..255	CDD:278578	35/100 (35%)
		Mito_carr	264..364	CDD:278578	39/101 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341334
Domainoid	1	1.000	71	1.000	Domainoid score	I2242
eggNOG	1	0.900	-	-		E1_KOG0761
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6040
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1011
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53824
OrthoFinder	1	1.000	-	-		FOG0001594
OrthoInspector	1	1.000	-	-		otm46805
orthoMCL	1	0.900	-	-		OOG6_101405
Panther	1	1.100	-	-	O	PTHR45760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2199
SonicParanoid	1	1.000	-	-		X1001
TreeFam	1	0.960	-	-
	15	14.790