Protein Alignment alphaTub84D and TUBE1

DIOPT Version :10

• Sequence 1: NP_524264.1
• Gene: alphaTub84D / 40904
• FlyBaseID: FBgn0003885
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_057346.1
• Gene: TUBE1 / 51175
• HGNCID: 20775
• Length: 475
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 145/483 - (30%)
• Similarity: 239/483 - (49%)
• Gaps: 74/483 - (15%)

  Fly     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSE-----TGAGK 60
            |.:.:.:.|||.|.|||...|:|...||.        :....|..|::.::||..     .|.|.
Human     1 MTQSVVVQVGQCGNQIGCCFWDLALREHA--------AVNQKGIYDEAISSFFRNVDTRVVGDGG 57

  Fly    61 HV---------PRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVD 116
            .:         .|||.:|:|..||:|:..|..|.:|..:||||....:.||:|.||...|....|
Human    58 SISKGKICSLKARAVLIDMEEGVVNEILQGPLRDVFDTKQLITDISGSGNNWAVGHKVFGSLYQD 122

  Fly   117 LVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAVYPAPQVSTAV 181
            .:|::.||.|:.|..||.|.|.||.|||||||..:.|::.|..::.:..:...::||:.: ...:
Human   123 QILEKFRKSAEHCDCLQCFFIIHSMGGGTGSGLGTFLLKVLEDEFPEVYRFVTSIYPSGE-DDVI 186

  Fly   182 VEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDI--------------------------- 219
            ..||||||......||:||...:||::::||..: :|:
Human   187 TSPYNSILAMKELNEHADCVLPIDNQSLFDIISK-IDLMVNSGKLGTTVKPKSLVTSSSGALKKQ 250

  Fly   220 ERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHF------PLVTYAPVISA 278
            .:..:..:|.::..::.::|:|.||:|:||:||.|...||||:|::|:      ||.|...|...
Human   251 HKKPFDAMNNIVANLLLNLTSSARFEGSLNMDLNEISMNLVPFPQLHYLVSSLTPLYTLTDVNIP 315

  Fly   279 EKAYHEQLSVAEITNACFEPANQMVKVDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQF 343
            .:...:..|.|      |...:|:::.||:|..|:||.::.||:|...|:...|..:|.  ::||
Human   316 PRRLDQMFSDA------FSKDHQLLRADPKHSLYLACALMVRGNVQISDLRRNIERLKP--SLQF 372

  Fly   344 VDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWY 408
            |.|...|:|..:...||.    |.    ..::..|:|.|.:...:..|..:|..:|.|:|.:|.|
Human   373 VSWNQEGWKTSLCSVPPV----GH----SHSLLALANNTCVKPTFMELKERFMRLYKKKAHLHHY 429

  Fly   409 VG-EGMEEGEFSEAREDLAALEKDYEEV 435
            :. |||||..|:||...|:||.::|:::
Human   430 LQVEGMEESCFTEAVSSLSALIQEYDQL 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub84D	NP_524264.1	PTZ00335	1..439	CDD:185562	145/483 (30%)
TUBE1	NP_057346.1	epsilon_tubulin	2..457	CDD:276959	144/480 (30%)