DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and cest-6

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_501070.1	Gene:	cest-6 / 177459	WormBaseID:	WBGene00020688	Length:	583	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	145/563 - (25%)
Similarity:	223/563 - (39%)	Gaps:	131/563 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NGDFIQQVISFKYEQRKLSTAIYSVIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFK 90
            |.|.:..|:...|...|...|  .||.|..|.:.|   |.|  |||.:|:||||||||:|.|||:
Worm     3 NFDMLIFVLLIVYSAYKSCEA--GVITTSLGSING---NQI--GSYQTFKKIPFAKPPIGKLRFQ 60

  Fly    91 APEAVEPWDQELDCT---------SPADKPLQTHMFFRKYAGSEDCLYLNVYVKD-LQPDKLRPV 145
            .|.|.|.|:..|:.|         |...|..|..:       .||||::|::..| ....|...|
Worm    61 KPMAAEKWEGILNATEYGPACMSNSSTSKSPQKWI-------DEDCLHINIFTTDTCLSSKNCSV 118

  Fly   146 MVWIYGGG--YQVGEASRDMYSPDFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQI 208
            :.:::||.  |.......|.|..|.|.|:||::|..|:|||......::|..: .|.|..|.|.:
Worm   119 VFYVHGGELVYDSAVMFEDKYLFDTFSSRDVILVIPAFRLGLFSHFVVEDQNV-APNNLALYDIL 182

  Fly   209 MALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQ--TEGLIHKAIVMSGSVLCPWTQPP 271
            :||.:|:..|..|||.|:.:|.||.|.||.....:|.|.:  |:....:.::...||
Worm   183 LALEFVKSEIHNFGGSSDRVTAFGHSYGGHVVSVMAFSTEINTDLSYFQRVICMSSV-------- 239

  Fly   272 RNNW---------AYRLAQ----------KLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSND 317
             |.|         ..|..|          |...|...:|..:.|.|:.:...|:::...::  .|
Worm   240 -NVWDSLEFEIEKTMRFIQYANCSVPQDLKSRMTSFEQDSYMMECLQDIDSMELLRIQRSL--ED 301

  Fly   318 EKH--HRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPA 380
            |.|  :..|....|:::      .|:.:..:|..:|     ||.:.|.|       |.|
Worm   302 EGHPIYSGLVLREPLIQ------NVLVQDFYEKPKN-----IPTLTGCT-------YKE------ 342

  Fly   381 TLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYR 445
             ||:.....|::.: ||.       ||| .:....|..|....:.::.|..:     |.:..:.:
Worm   343 -LDKFHAYHNIVET-LGY-------ENY-KECDDKYRDDRKYGRFDLNKHAD-----ETFGILAQ 392

  Fly   446 AALNRVRQ--SSAPTYLYRFD---HDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAP 505
            ..|...:|  ...|||.|.:.   |.|                   |.|||.||   |..|....
Worm   393 TKLKVDKQLDKGIPTYFYEYSYPKHPS-------------------HTDDLSYI---MGVHAFEK 435

  Fly   506 DSPEHKVITGMVDVWTSFAAHGDPNCESIKSLKFAPIENVTNF 548
            |..|..:.....:::.:|...|:|.    ...:.:..||.:.|
Worm   436 DENEIHLAKSYQEMFMNFVKFGEPG----GGFEMSTFENSSYF 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	136/532 (26%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	44/160 (28%)
cest-6	NP_501070.1	Abhydrolase	25..500	CDD:389770	139/539 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740