Protein Alignment alpha-Est10 and cest-6

DIOPT Version :10

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_501070.1
• Gene: cest-6 / 177459
• WormBaseID: WBGene00020688
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 563
• Identity: 145/563 - (25%)
• Similarity: 223/563 - (39%)
• Gaps: 131/563 - (23%)

  Fly    26 NGDFIQQVISFKYEQRKLSTAIYSVIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFK 90
            |.|.:..|:...|...|...|  .||.|..|.:.|   |.|  |||.:|:||||||||:|.|||:
 Worm     3 NFDMLIFVLLIVYSAYKSCEA--GVITTSLGSING---NQI--GSYQTFKKIPFAKPPIGKLRFQ 60

  Fly    91 APEAVEPWDQELDCT---------SPADKPLQTHMFFRKYAGSEDCLYLNVYVKD-LQPDKLRPV 145
            .|.|.|.|:..|:.|         |...|..|..:       .||||::|::..| ....|...|
 Worm    61 KPMAAEKWEGILNATEYGPACMSNSSTSKSPQKWI-------DEDCLHINIFTTDTCLSSKNCSV 118

  Fly   146 MVWIYGGG--YQVGEASRDMYSPDFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQI 208
            :.:::||.  |.......|.|..|.|.|:||::|..|:|||......::|..: .|.|..|.|.:
 Worm   119 VFYVHGGELVYDSAVMFEDKYLFDTFSSRDVILVIPAFRLGLFSHFVVEDQNV-APNNLALYDIL 182

  Fly   209 MALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQ--TEGLIHKAIVMSGSVLCPWTQPP 271
            :||.:|:..|..|||.|:.:|.||.|.||.....:|.|.:  |:....:.::...||
 Worm   183 LALEFVKSEIHNFGGSSDRVTAFGHSYGGHVVSVMAFSTEINTDLSYFQRVICMSSV-------- 239

  Fly   272 RNNW---------AYRLAQ----------KLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSND 317
             |.|         ..|..|          |...|...:|..:.|.|:.:...|:::...::  .|
 Worm   240 -NVWDSLEFEIEKTMRFIQYANCSVPQDLKSRMTSFEQDSYMMECLQDIDSMELLRIQRSL--ED 301

  Fly   318 EKH--HRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPA 380
            |.|  :..|....|:::      .|:.:..:|..:|     ||.:.|.|       |.|
 Worm   302 EGHPIYSGLVLREPLIQ------NVLVQDFYEKPKN-----IPTLTGCT-------YKE------ 342

  Fly   381 TLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYR 445
             ||:.....|::.: ||.       ||| .:....|..|....:.::.|..:     |.:..:.:
 Worm   343 -LDKFHAYHNIVET-LGY-------ENY-KECDDKYRDDRKYGRFDLNKHAD-----ETFGILAQ 392

  Fly   446 AALNRVRQ--SSAPTYLYRFD---HDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAP 505
            ..|...:|  ...|||.|.:.   |.|                   |.|||.||   |..|....
 Worm   393 TKLKVDKQLDKGIPTYFYEYSYPKHPS-------------------HTDDLSYI---MGVHAFEK 435

  Fly   506 DSPEHKVITGMVDVWTSFAAHGDPNCESIKSLKFAPIENVTNF 548
            |..|..:.....:::.:|...|:|.    ...:.:..||.:.|
 Worm   436 DENEIHLAKSYQEMFMNFVKFGEPG----GGFEMSTFENSSYF 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..533	CDD:395084	136/523 (26%)
cest-6	NP_501070.1	alpha/beta hydrolases	25..500	CDD:473884	139/539 (26%)