Protein Alignment Ir84a and grin2bb

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001121809.1
• Gene: grin2bb / 559976
• ZFINID: ZDB-GENE-061207-27
• Length: 1770
• Species: Danio rerio
• Alignment Length: 725
• Identity: 121/725 - (16%)
• Similarity: 233/725 - (32%)
• Gaps: 214/725 - (29%)

  Fly    47 LSHVLVVRGDDADGDWKIECHQKLLANYRVQFYRPEMSANFEDLMFYGSPRTAVLVLNSEHVLVR 111
            |..||::.....|||.||:...|.|.:..:..|..:..|.
Zfish   273 LEEVLLLDMSVDDGDSKIQNQMKKLQSPVILLYCTKEEAT------------------------- 312

  Fly   112 RQVFGVASEAGYFNNSLAWFI---LGSGRESLP---VEQLIDQLLSGYRMGIDADI--TVALRGP 168
             .:|.||...|.......|.:   :....:::|   ...||......:..|::|.:  .||:...
Zfish   313 -TIFEVAHSVGLTGYGYTWIVPSLVAGDTDNVPNVFPTGLISVSYDEWDYGLEARVRDAVAIIAM 376

  Fly   169 DNASMLFYDVYRISRQANTPL------IIEKKGLWTHSGGYQKFGNFKNTWVIRRRNFLNVTLIG 227
            ..::|:      :.|..:|.|      ..:|||        .|.||....    .|..:|||..|
Zfish   377 ATSTMM------LDRGPHTLLKSGCHGAPDKKG--------SKSGNPNEV----LRYLMNVTFEG 423

  Fly   228 ST----------------VLTEKP---------------------PGF---GDMEYLADDKQ--- 249
            ..                :|..|.                     |.|   .|.|...||..
Zfish   424 RNLSFSEDGFQMHPKLVIILLNKERQYERVGKWENGSLAMKYHVWPRFELYSDAEEREDDHLSIV 488

  Fly   250 ---------LQQLDPMQ----------RKTYQLFQL-------VER-----------------MF 271
                     ::.:||:.          ||..:|..|       ::|                 .|
Zfish   489 TLEEAPFVIVEDVDPLSGTCMRNTVPCRKQLKLQNLTGDSGIYIKRCCKGFCIDILKKIAKSVKF 553

  Fly   272 NLSLAISLTDKWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLF 336
            ...|.:....|.|:.: ||:|:|::|:|..:.|..||..:....:|...:.:|.......|..:.
Zfish   554 TYDLYLVTNGKHGKKI-NGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMV 617

  Fly   337 RHPRRSHIKNIFFEPLSNQVW--WCVLALVTGSTILLLFH----VRLERMLSN----------ME 385
            .....:...:.|.||.|..||  ..|:.|:..:..:.:|.    |...|.|::          :.
Zfish   618 SRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIG 682

  Fly   386 NRFSFVWFTMLETYLQ-QGPANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIV 449
            .....:|..:....:. |.|...     ::::::|:...|:.:.:..|.|.:...::.|.....|
Zfish   683 KAIWLLWGLVFNNSVPVQNPKGT-----TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQV 742

  Fly   450 NLQALYDSNLAIGMENISYNFP-----------IFTNTSNQLVRDVYVKKICKSGEHNIM----- 498
            .           |:.:..:..|           :...::.:.:|:.|.:.      |:.|
Zfish   743 T-----------GLSDKKFQHPNDFSPPFRFGTVPNGSTERNIRNNYKEM------HSYMTSFHQ 790

  Fly   499 -SLQQGAERIIQGR---FAFHTAIDRMYRLLLELQMDEAEFCDLQEVMFNLPYDS---GSVMPKG 556
             ::.:....:..|:   |.:..|:       |.......|.|.|..:.....:.:   |..:.|.
Zfish   791 KNVNEALHSLKSGKLDAFIYDAAV-------LNYMAGRDEGCKLVTIGSGYIFATTGYGIAIQKD 848

  Fly   557 SPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAEVDLEHFAPALFALALAMVASAL 621
            |.|:..:..|:|.....|.::..:..|:.........:...:::|:::.|...:.|..||..|.:
Zfish   849 SGWKRAVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDVDNMAGVFYMLGAAMALSLI 913

  Fly   622 VFLLELFLHW 631
            .|:.|...:|
Zfish   914 TFIAEHLFYW 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	9/57 (16%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	18/72 (25%)
		Lig_chan	353..602	CDD:459656	39/288 (14%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..465	CDD:380601	41/235 (17%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	67/429 (16%)
		NMDAR2_C	919..1770	CDD:463148	1/5 (20%)