Protein Alignment Ir84a and Gria3

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_058582.4
• Gene: Gria3 / 53623
• MGIID: 95810
• Length: 888
• Species: Mus musculus
• Alignment Length: 602
• Identity: 143/602 - (23%)
• Similarity: 245/602 - (40%)
• Gaps: 131/602 - (21%)

  Fly    93 YGSPRT--AVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFILGSGRESLPVEQLIDQLLSGYRM 155
            |.|..|  |:||:......:|||...| |..|...:.||       ..::|..|
Mouse   299 YTSALTHDAILVIAEAFRYLRRQRVDV-SRRGSAGDCLA-------NPAVPWSQ----------- 344

  Fly   156 GIDADITVALRGPDNASM---LFYDVYRISRQANTPLII--------EKKGLWTHSGGYQKFGNF 209
            ||  ||..||:......|   :.:|.|  .|:.|..:.:        .|.|.|..   |::|..|
Mouse   345 GI--DIERALKMVQVQGMTGNIQFDTY--GRRTNYTIDVYEMKVSGSRKAGYWNE---YERFVPF 402

  Fly   210 KNTWVIR-RRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQR-------KTYQLFQL 266
            .:..:.. ..:..|.|::.:|:| |.|       |:...|..:||:..:|       ..|::.:.
Mouse   403 SDQQISNDSSSSENRTIVVTTIL-ESP-------YVMYKKNHEQLEGNERYEGYCVDLAYEIAKH 459

  Fly   267 VERMFNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQ 330
            |...:.||:...  .|:|.. .:...|:|::|::....||.||.|:...|.|:..:.:|....:.
Mouse   460 VRIKYKLSIVGD--GKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSL 522

  Fly   331 NIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLERMLSNMENR------- 387
            .|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|......::|:.
Mouse   523 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 587

  Fly   388 ------------FSFVWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFI 436
                        |:.:||: |..::|||    |     |..|.|::..:...|:.:::..|.|.:
Mouse   588 QSPPDPPNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANL 646

  Fly   437 VGSLLSESARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVR----DVYVK--KICKSGEH 495
            ...|..|  |.:..:::..|  ||...| |:|. .:.:.::.:..|    .||.|  ...||.|.
Mouse   647 AAFLTVE--RMVSPIESAED--LAKQTE-IAYG-TLDSGSTKEFFRRSKIAVYEKMWSYMKSAEP 705

  Fly   496 NIM--SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS--- 549
            ::.  :...|..|:  .:|:|||          |||..|:|    .:.||..:|..||  ||
Mouse   706 SVFTKTTADGVARVRKSKGKFAF----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGY 758

  Fly   550 GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC----SLFKTSQAEVDLEHFAPALF 610
            |...||||..|..:..|:|.....|:|.....||...:.:|    |..|...:.:.|.:.|...:
Mouse   759 GVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFY 823

  Fly   611 ----ALALAMVASALVF 623
                .|.|||:.:.:.|
Mouse   824 ILVGGLGLAMMVALIEF 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	6/20 (30%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	19/74 (26%)
		Lig_chan	353..602	CDD:459656	69/292 (24%)
Gria3	NP_058582.4	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	32/129 (25%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	100/416 (24%)