Protein Alignment Ir84a and Gria1

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_113796.1
• Gene: Gria1 / 50592
• RGDID: 621531
• Length: 907
• Species: Rattus norvegicus
• Alignment Length: 713
• Identity: 154/713 - (21%)
• Similarity: 268/713 - (37%)
• Gaps: 188/713 - (26%)

  Fly     1 MIKLQVKVISWPLIILTAFLRVLQIE-------SINTNFLELAAFEDFL---------RSEHLSH 49
            ::||:...|.:..|:  |.|..:.|:       ..|....:|..:.|.:         .|:...|
  Rat   216 IVKLEKNGIGYHYIL--ANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDH 278

  Fly    50 VLVVRGDDADGDWKIECHQKLLANYRVQFYRPEMSANFEDLMFYGSPRT--AVLVLNSEHVLVRR 112
            ..|        |||                ||:          |.|..|  .|.|:......:||
  Rat   279 TRV--------DWK----------------RPK----------YTSALTYDGVKVMAEAFQSLRR 309

  Fly   113 QVFGVA--SEAG--YFNNSLAWFILGSGRESLPVEQLIDQLLSGYRM-GIDADITVALRGPDNAS 172
            |...::  ..||  ..|.::.|   |.|   :.:::.:.|:    |. |:..::....:|
  Rat   310 QRIDISRRGNAGDCLANPAVPW---GQG---IDIQRALQQV----RFEGLTGNVQFNEKG----- 359

  Fly   173 MLFYDVYRISRQANTPL-IIEKK-------GLWTHSGGY-------QKFGNFKNTWVIRRRNFLN 222
                      |:.|..| :||.|       |.|.....:       |..|:  |:.|..|
  Rat   360 ----------RRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGD--NSSVQNR----- 407

  Fly   223 VTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERM-----FNLSLAISLTDK 282
             |.|.:|:| |.|       |:...|...|.:...|......:|...:     ::..|.|....|
  Rat   408 -TYIVTTIL-EDP-------YVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGK 463

  Fly   283 WGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKN 346
            :|.. .|..:|:|::|::....||.||.|:...|.|:..:.:|....:..|..:.:.|::|....
  Rat   464 YGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 528

  Fly   347 I-FFEPLSNQVWWCVLALVTGSTILLL--------------FHVRLERMLSNMENRFSF---VWF 393
            . |.:||:.::|.|::....|.:::|.              |....::..|:..|.|..   :||
  Rat   529 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWF 593

  Fly   394 TMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQAL 454
            : |..::|||    |     |..|.|::..:...|:.:::..|.|.:...|..|  |.:..:::.
  Rat   594 S-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVE--RMVSPIESA 650

  Fly   455 YD----SNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM--SLQQGAERI--IQGR 511
            .|    :.:|.|..........|..:...:...::.  ..||.|.::.  :.::|..|:  .:|:
  Rat   651 EDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWT--YMKSAEPSVFVRTTEEGMIRVRKSKGK 713

  Fly   512 FAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS---GSVMPKGSPWREHLAHALLH 569
            :|:          |||..|:|    .:.||..:|..||  ||   |...||||..|..:..|:|.
  Rat   714 YAY----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGYGIATPKGSALRNPVNLAVLK 766

  Fly   570 FRATGLLQYNDKKWMVRRPDC------SLFKTSQAEVDLEHFAPALFALALAMVASALVFLLE 626
            ....|||.....||...:.:|      |..|||  .:.|.:.|...:.|...:..:.||.|:|
  Rat   767 LNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTS--ALSLSNVAGVFYILIGGLGLAMLVALIE 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	10/59 (17%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	20/74 (27%)
		Lig_chan	353..602	CDD:459656	65/290 (22%)
Gria1	NP_113796.1	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	44/236 (19%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	94/416 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907