Protein Alignment Ir84a and gria4a

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_999971.1
• Gene: gria4a / 407735
• ZFINID: ZDB-GENE-020125-7
• Length: 898
• Species: Danio rerio
• Alignment Length: 613
• Identity: 140/613 - (22%)
• Similarity: 246/613 - (40%)
• Gaps: 151/613 - (24%)

  Fly    93 YGSPRT--AVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFILGSGRESLPVEQLIDQLLSGYRM 155
            |.|..|  .|||:......:|||...: |..|...:.||       ..:.|           :..
Zfish   291 YTSSLTYDGVLVMAEAFRNLRRQKIDI-SRRGNAGDCLA-------NPAAP-----------WNQ 336

  Fly   156 GIDADIT---VALRGPDNASMLFYDVYRISRQAN-TPLIIEKKGLWTHSGGYQKFGNFKN-TWVI 215
            |||.:.|   |.::|  ....:.:|.|  .|:.| |..:.|.|     |.|.:|.|.:.: ..::
Zfish   337 GIDMERTLKQVRIQG--LTGNIQFDHY--GRRVNYTMDVFELK-----SNGPRKIGYWNDLDKLV 392

  Fly   216 RRRNFL---------NVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERM- 270
            ..:|.|         |.|:|.:|:: |.|       |:           |.:|.:::::..|:.
Zfish   393 LVQNELSMGNDSAMENRTVIVTTIM-EGP-------YV-----------MLKKNWEMYEGNEQFE 438

  Fly   271 ---------------FNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQP 319
                           ....::|.|..|:|.. .:...|:|::|::...:|:.||.|:...|.|:.
Zfish   439 GYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLAITLVREE 503

  Fly   320 YVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLERMLSN 383
            .:.:|....:..|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|......:
Zfish   504 VIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH 568

  Fly   384 MENR------------------FSFVWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSF 426
            .|..                  |:.:||: |..::|||    |     |..|.|::..:...|:.
Zfish   569 TEEPEEGSDGPPSDQPPNEFGIFNSLWFS-LGAFMQQGCDFTP-----RSLSGRIVGGVWWFFTL 627

  Fly   427 MLMQFYGAFIVGSLLSESARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVR----DVYVK 487
            :::..|.|.:...|..|  |.:..:::..|  ||...| |:|. .:.:.::.:..|    .||.|
Zfish   628 IIISSYTANLAAFLTVE--RMVSPIESAED--LAKQTE-IAYG-TLDSGSTKEFFRRSKIAVYEK 686

  Fly   488 --KICKSGEHNIM--SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDLQEVM 542
              ...||.|..:.  :..:|..|:  .:|::||          |||..|:|    .:.||..:|.
Zfish   687 MWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAF----------LLESTMNEYTEQRKPCDTMKVG 741

  Fly   543 FNLPYDS---GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC------SLFKTSQA 598
            .||  ||   |...||||.....:..|:|.....|:|.....||...:.:|      |..|:|||
Zfish   742 GNL--DSKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKSSQA 804

  Fly   599 EVDLEHFAPALFALALAMVASALVFLLE 626
             :.|.:.|...:.|...:..:.||.|:|
Zfish   805 -LSLSNVAGVFYILVGGLGLAMLVALVE 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	6/20 (30%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	18/74 (24%)
		Lig_chan	353..602	CDD:459656	70/293 (24%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..395	CDD:380611	31/131 (24%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	94/424 (22%)