Protein Alignment Ir84a and Grin2a

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_036705.3
• Gene: Grin2a / 24409
• RGDID: 2737
• Length: 1464
• Species: Rattus norvegicus
• Alignment Length: 692
• Identity: 126/692 - (18%)
• Similarity: 228/692 - (32%)
• Gaps: 197/692 - (28%)

  Fly    83 MSANFED--------------LMFYGSPRTAVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFI- 132
            :..:|||              ::.|.|...|||:|:.            |...|.......|.:
  Rat   206 LDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSE------------ARSLGLTGYDFFWIVP 258

  Fly   133 -LGSGRESLPVEQLIDQLLS-GYRMGIDADITVALRGPDNASMLF-----------------YDV 178
             |.||...|..::....|:| .|.   |.|.::..|..|...:|.                 ...
  Rat   259 SLVSGNTELIPKEFPSGLISVSYD---DWDYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASC 320

  Fly   179 YRISRQANTPL----------IIEKKGLWTHSGGYQ-----------------KFGNFKNTWVIR 216
            |..:.:..|||          ..:.|.|.....|||                 |.|.::|.
  Rat   321 YGQAEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQ---- 381

  Fly   217 RRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQL-------------QQLDPMQ----------R 258
                   ||.....:..:...|.|.|  .||..|             :.:||:.          |
  Rat   382 -------TLSLRHAVWPRYKSFSDCE--PDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCR 437

  Fly   259 KTYQL------------------FQLVERM-----FNLSLAISLTDKWGELLDNGSWSGVMGQVT 300
            |..::                  ..:::::     |...|.:....|.|:.::| .|:|::|:|.
  Rat   438 KFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNN-VWNGMIGEVV 501

  Fly   301 SREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNIFFEPLSNQVW--WCVLAL 363
            .:.|..||..:....:|...|.:|.......|..:......:...:.|.||.|..||  ..|:.|
  Rat   502 YQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLL 566

  Fly   364 VTGSTILLLFH----VRLERMLS----------NMENRFSFVWFTMLETYLQ-QGPANEIFRLFS 413
            :..:..:.:|.    |...|.|:          .:......:|..:....:. |.|...     :
  Rat   567 IVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT-----T 626

  Fly   414 TRLLISLSCIFSFMLMQFYGAFIVGSLLSE------SARSIVNLQALYDSN--LAIGM------- 463
            :::::|:...|:.:.:..|.|.:...::.|      :..|....|..:|.:  ...|.
  Rat   627 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTE 691

  Fly   464 ENISYNFPIFTNTSNQLVRDVYVKKICKSG-EHNIMSLQQGAERIIQGRFAFHTAIDRMYRLLLE 527
            .||..|:|....         |:.:..:.| |..::||:.|.    ...|.:..|:       |.
  Rat   692 RNIRNNYPYMHQ---------YMTRFNQRGVEDALVSLKTGK----LDAFIYDAAV-------LN 736

  Fly   528 LQMDEAEFCDLQEVMFNLPYDS---GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPD 589
            .:....|.|.|..:.....:.:   |..:.|||||:..:..|||.|...|.::..:..|:.....
  Rat   737 YKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH 801

  Fly   590 CSLFKTSQAEVDLEHFAPALFALALAMVASALVFLLELFLHW 631
            ....:...:::|:::.|...:.||.||..|.:.|:.|...:|
  Rat   802 NEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYW 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	9/42 (21%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	18/72 (25%)
		Lig_chan	353..602	CDD:459656	49/284 (17%)
Grin2a	NP_036705.3	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	38/206 (18%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	74/424 (17%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1	599..620		1/20 (5%)
		NMDAR2_C	839..1464	CDD:463148	1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1083
		PDZ-binding. /evidence=ECO:0000305	1462..1464