Protein Alignment Ir84a and Grin3a

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_612555.1
• Gene: Grin3a / 191573
• RGDID: 621704
• Length: 1135
• Species: Rattus norvegicus
• Alignment Length: 810
• Identity: 164/810 - (20%)
• Similarity: 282/810 - (34%)
• Gaps: 212/810 - (26%)

  Fly     4 LQVKVISWPLIILTAFLRVLQIESINTNFLELAAFEDFLRSEHLSHVLVVRGDD--------ADG 60
            |.:.|:|   |:...|.|    ||.|...|:| :.|:.|.|:....|.::..::        ...
  Rat   216 LHIPVLS---IVRHEFPR----ESQNPLHLQL-SLENSLSSDADVTVSILTMNNWYNFSLLLCQE 272

  Fly    61 DWKIECHQKLLANYRVQFYRP---EMSANF---EDLMFY----------GSPRTAVLVLNSEHVL 109
            ||.| ....||.....:|:..   .::||.   :||:.:          .:|...:...:.:.:
  Rat   273 DWNI-TDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSI- 335

  Fly   110 VRRQVFGVASEAGYFNNSLAWFILGSGRESLPVEQLIDQLLSGYRMGIDAD-------------- 160
              ||:|.::::.|.....|.| :||   :|..||:|..:   |..:|:.|.
  Rat   336 --RQIFEMSTQFGLSPPELHW-VLG---DSQNVEELRTE---GLPLGLIAHGKTTQSVFEYYVQD 391

  Fly   161 ---------ITVALRGPDNA----SMLFYDV---------YRISRQANTPL-----IIEKKG--- 195
                     .|..:..|:.|    :|...||         |.....|||..     .|:.||
  Rat   392 AMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTI 456

  Fly   196 --------------------LWTHSGGYQ--KFGNFKNTWV---------IRRRNFLNVTLIGST 229
                                :||..|.:|  :.......|.         .:..|.|::.::
  Rat   457 ISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVV--- 518

  Fly   230 VLTEKPPGFG---DMEYLADDKQLQQLDPMQRKTY---QLF------------------------ 264
            .|.|.|..|.   |.|.|....|| .||||...:.   :||
  Rat   519 TLIEHPFVFTREVDDEGLCPAGQL-CLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCID 582

  Fly   265 ---QLVERM-FNLSLAISLTDKWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSA 325
               ||.|.| |:..|.|....|:| ...||.|:|::|.:.|..|:.||........|...:.:::
  Rat   583 LLEQLAEDMNFDFDLYIVGDGKYG-AWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTS 646

  Fly   326 VLHTQNIHFLFRHPRRSHIKNIFFEPLSNQVWWCV-LALVTGSTILLLFHVRLE-RMLSNMENR- 387
            ...:.::..|.|....:.....|..||...:|..: :||...:..|.|:..:.. .|.....||
  Rat   647 PFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRN 711

  Fly   388 --FSF-----VWFTML--ETYLQQGPANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSE 443
              |||     |.:.:|  .|...:.|     :.::.|.|::|..||....:..|.|.:...::.|
  Rat   712 KVFSFSSALNVCYALLFGRTAAIKPP-----KCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGE 771

  Fly   444 SARSIVNLQALYDSNLAIGMENISYNFPIFT---NTSNQLVRDVYVKKICKSGEHNIMSLQQGAE 505
              :....|..::|..|    .:.|..|...|   :::...||..:.:.......:|:.:...|.:
  Rat   772 --KIYEELSGIHDPKL----HHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQ 830

  Fly   506 RIIQGRFAFHTAIDRMYRLLLELQMDEAEFCDLQEVMFNLPY---DSGSVMPKGSPWREHLAHAL 567
            .:..........|  |.:.||:.::.....|.|..|  ..|:   ..|..:|..||...:::..:
  Rat   831 YLKNDPEKLDAFI--MDKALLDYEVSIDADCKLLTV--GKPFAIEGYGIGLPPNSPLTSNISELI 891

  Fly   568 LHFRATGLLQYNDKKWMVRRPDC---SLFKTSQAEVDLEHFAPALFALALAMVASALVFL----- 624
            ..:::.|.:.....||....| |   |...|...::.::||:.....|.:....|.|..:
  Rat   892 SQYKSHGFMDVLHDKWYKVVP-CGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIV 955

  Fly   625 -------------LELFLHWLPDFRRRLGT 641
                         |:.:||....|.|.|.|
  Rat   956 HRLLLPRIKNKSKLQYWLHTSQRFHRALNT 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	11/81 (14%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	17/72 (24%)
		Lig_chan	353..602	CDD:459656	52/269 (19%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	58/298 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..117
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	87/415 (21%)
		Lig_chan	674..941	CDD:459656	55/282 (20%)
		PPP2CB binding site. /evidence=ECO:0000269|PubMed:11588171	951..987		7/35 (20%)
		GIT1-binding. /evidence=ECO:0000269|PubMed:24297929	1082..1115