Protein Alignment Ir84a and Grin2a

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 692
• Identity: 127/692 - (18%)
• Similarity: 228/692 - (32%)
• Gaps: 197/692 - (28%)

  Fly    83 MSANFED--------------LMFYGSPRTAVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFI- 132
            :..:|||              ::.|.|...|||:|:.            |...|.......|.:
Mouse   206 LDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSE------------ARSLGLTGYDFFWIVP 258

  Fly   133 -LGSGRESLPVEQLIDQLLS-GYRMGIDADITVALRGPDNASMLF-----------------YDV 178
             |.||...|..::....|:| .|.   |.|.::..|..|...:|.                 ...
Mouse   259 SLVSGNTELIPKEFPSGLISVSYD---DWDYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASC 320

  Fly   179 YRISRQANTPL----------IIEKKGLWTHSGGYQ-----------------KFGNFKNTWVIR 216
            |..:.:..|||          ..:.|.|.....|||                 |.|.::|.
Mouse   321 YGQTEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQ---- 381

  Fly   217 RRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQL-------------QQLDPMQ----------R 258
                   ||.....:..:...|.|.|  .||..|             :.:||:.          |
Mouse   382 -------TLSLRHAVWPRYKSFSDCE--PDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCR 437

  Fly   259 KTYQL------------------FQLVERM-----FNLSLAISLTDKWGELLDNGSWSGVMGQVT 300
            |..::                  ..:::::     |...|.:....|.|:.::| .|:|::|:|.
Mouse   438 KFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNN-VWNGMIGEVV 501

  Fly   301 SREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNIFFEPLSNQVW--WCVLAL 363
            .:.|..||..:....:|...|.:|.......|..:......:...:.|.||.|..||  ..|:.|
Mouse   502 YQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLL 566

  Fly   364 VTGSTILLLFH----VRLERMLS----------NMENRFSFVWFTMLETYLQ-QGPANEIFRLFS 413
            :..:..:.:|.    |...|.|:          .:......:|..:....:. |.|...     :
Mouse   567 IVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT-----T 626

  Fly   414 TRLLISLSCIFSFMLMQFYGAFIVGSLLSE------SARSIVNLQALYDSN--LAIGM------- 463
            :::::|:...|:.:.:..|.|.:...::.|      :..|....|..:|.:  ...|.
Mouse   627 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTE 691

  Fly   464 ENISYNFPIFTNTSNQLVRDVYVKKICKSG-EHNIMSLQQGAERIIQGRFAFHTAIDRMYRLLLE 527
            .||..|:|....         |:.|..:.| |..::||:.|.    ...|.:..|:       |.
Mouse   692 RNIRNNYPYMHQ---------YMTKFNQRGVEDALVSLKTGK----LDAFIYDAAV-------LN 736

  Fly   528 LQMDEAEFCDLQEVMFNLPYDS---GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPD 589
            .:....|.|.|..:.....:.:   |..:.|||||:..:..|||.|...|.::..:..|:.....
Mouse   737 YKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH 801

  Fly   590 CSLFKTSQAEVDLEHFAPALFALALAMVASALVFLLELFLHW 631
            ....:...:::|:::.|...:.||.||..|.:.|:.|...:|
Mouse   802 NEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYW 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	9/42 (21%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	18/72 (25%)
		Lig_chan	353..602	CDD:459656	50/284 (18%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	38/206 (18%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	75/424 (18%)
		NMDAR2_C	839..1464	CDD:463148	1/5 (20%)