Protein Alignment Ir84a and Gria2

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001344853.2
• Gene: Gria2 / 14800
• MGIID: 95809
• Length: 901
• Species: Mus musculus
• Alignment Length: 680
• Identity: 141/680 - (20%)
• Similarity: 261/680 - (38%)
• Gaps: 147/680 - (21%)

  Fly    49 HVLVVRGDDADGD-WKIECHQKLLANYRVQFYRPEMSANF-------EDLMFYGS-----PRTAV 100
            |.::......||| .||:.....::.:::..|...:.:.|       |:..:.|:     ..|:.
Mouse   234 HYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSA 298

  Fly   101 LVLNSEHVL------VRRQVFGVA--SEAG--YFNNSLAWFILGSGRESLPVEQLIDQL----LS 151
            |..::..|:      :|:|...::  ..||  ..|.::.|   |.|.|   :|:.:.|:    ||
Mouse   299 LTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPW---GQGVE---IERALKQVQVEGLS 357

  Fly   152 GYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLWTH-----------SGGYQK 205
            |           .::...|...:.|.:..:..:.|.|   .|.|.|:.           ..|...
Mouse   358 G-----------NIKFDQNGKRINYTINIMELKTNGP---RKIGYWSEVDKMVVTLTELPSGNDT 408

  Fly   206 FGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERM 270
            .|            ..|.|::.:|:| |.|       |:...|..:.|:..:|.......|...:
Mouse   409 SG------------LENKTVVVTTIL-ESP-------YVMMKKNHEMLEGNERYEGYCVDLAAEI 453

  Fly   271 -----FNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHT 329
                 |...|.|....|:|.. .|...|:|::|::...:||.|:.|:...|.|:..:.:|....:
Mouse   454 AKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518

  Fly   330 QNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRL--------------ER 379
            ..|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|.              |.
Mouse   519 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRET 583

  Fly   380 MLSNMENRFSF---VWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIV 437
            ..|...|.|..   :||: |..::|||    |     |..|.|::..:...|:.:::..|.|.:.
Mouse   584 QSSESTNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANLA 642

  Fly   438 GSLLSESARSIVNLQALYD----SNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM 498
            ..|..|  |.:..:::..|    :.:|.|..:.......|..:...:...::.  ..:|.|.::.
Mouse   643 AFLTVE--RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT--YMRSAEPSVF 703

  Fly   499 --SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS---GSV 552
              :..:|..|:  .:|::|:          |||..|:|    .:.||..:|..||  ||   |..
Mouse   704 VRTTAEGVARVRKSKGKYAY----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGYGIA 756

  Fly   553 MPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC----SLFKTSQAEVDLEHFAPALFALA 613
            .||||..|..:..|:|.....|:|.....||...:.:|    |..|...:.:.|.:.|...:.|.
Mouse   757 TPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILV 821

  Fly   614 LAMVASALVFLLELFLHWLPDFRRRLGTMS 643
            ..:..:.||.|:|.......:.:|...|:|
Mouse   822 GGLGLAMLVALIEFCYKSRAEAKRMKMTLS 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	12/76 (16%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	19/74 (26%)
		Lig_chan	353..602	CDD:459656	62/288 (22%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	34/183 (19%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	92/410 (22%)