Protein Alignment Ir84a and grin2ca

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 687
• Identity: 127/687 - (18%)
• Similarity: 239/687 - (34%)
• Gaps: 183/687 - (26%)

  Fly    82 EMSAN-FEDLMFYGSPRTAVLVLNSEHVLV------RRQVFGVASEAGYFNNSLAWFI--LGSGR 137
            :|||: ..||    ..|..:..::::.:||      .:.:|.:|.|.|.......|||  |..|.
Zfish   211 DMSADGMNDL----RARRLLQQIDAQVLLVYCSHDEAQYLFSMAREVGLVGPGYIWFIPSLAVGN 271

  Fly   138 ------ESLPVEQLIDQLLSGYRMG----IDADITVALRG-----------------------PD 169
                  :|.|| .||..:...::|.    :...:.:.::|                       |.
Zfish   272 PNIAPPDSFPV-GLISIITDRWKMSLRNRVRDGVAIVVKGVESFRKQRGFIPDGHMDCLSPIRPA 335

  Fly   170 NASMLFYDVYRISRQ------------ANTPLII---EKKGLWTHSGGYQ------------KFG 207
            :...|:..:..:|.:            .|..:||   ::...|...|.|:            ::|
Zfish   336 SNGTLYRHMLNVSWENTDFSFNSDGYLVNPSMIIITLDRGRQWDKVGNYESGILQMRYPVWPRYG 400

  Fly   208 NF----------------------------------KNTWVIRRRNFLNVTLIGSTVLTEKP--- 235
            .|                                  .||...||::....|::|.|    :|
Zfish   401 TFLEPVSDNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPCRRQSNKTETIVGHT----EPYTK 461

  Fly   236 ---PGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERMFNLSLAISLTDKWGELLDNGSWSGVMG 297
               .||             .:|.:::.:..:      .|:..|.:....|.|:|: .|.|:|::|
Zfish   462 LCCKGF-------------CIDILKKLSRNI------KFSYDLYLVTNGKHGKLV-RGIWNGMIG 506

  Fly   298 QVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNIFFEPLSNQVW--WCV 360
            :|..:.||.|:..:....:|...:.:|.......|..:......:...:.|.||.|..||  ..|
Zfish   507 EVFYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFV 571

  Fly   361 LALVTGSTILLLFH----VRLERMLSNMEN----RFSF---VWFTMLETYLQQGPANEIFRLFST 414
            :.|...:..:.:|.    |...|.|.:.::    .|:.   ||......:....|. |..:..::
Zfish   572 MCLTVVAVTVFVFEYCSPVGYNRSLVSAKDPGGPTFTIGKSVWLLWGIVFNNSVPI-ENPKGTTS 635

  Fly   415 RLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYDSNLAIGMENI-SYNFPIFTNTSN 478
            ::::.:...|:.:.:..|.|.:...::.|  :.|..:..|.|.......:.. .:.|....|.|.
Zfish   636 KIMVLVWAFFAVIFLASYTANLAAFMIQE--QYIDTVSGLSDKKFQKPQDQYPPFRFGTVPNGST 698

  Fly   479 QL-VRDVYVKKICKSGEHNIMSLQQGAERIIQGR---FAFHTAIDRMYRLLLELQMDEAEFCDL- 538
            :. :|..|.:......::|...::.....:..|:   |.:..|:       |.....:.|.|.|
Zfish   699 ERNIRSNYPEMHSHMVKYNQKGVEDALNSLKTGKLDAFIYDAAV-------LNYMAGKDEGCKLV 756

  Fly   539 ----QEVMFNLPYDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAE 599
                .:|.....|  |..:.|.|.|:..:..|||.|.|.|..|.....|:.     .:.:..:.|
Zfish   757 TIGSGKVFATTGY--GIALQKESRWKRPIDLALLQFLADGDTQKLQTVWLT-----GICRNEKKE 814

  Fly   600 V-----DLEHFAPALFALALAMVASALVFLLELFLHW 631
            |     |:::.|...:.|.:||..|.|||..|..|:|
Zfish   815 VMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYW 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	8/36 (22%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	18/72 (25%)
		Lig_chan	353..602	CDD:459656	50/276 (18%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..393	CDD:380601	33/186 (18%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	78/441 (18%)
		NMDAR2_C	847..>938	CDD:463148	2/5 (40%)