DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1227 and MYLK2

DIOPT Version :9

Sequence 1:	NP_001287207.1	Gene:	CG1227 / 40872	FlyBaseID:	FBgn0037491	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_149109.1	Gene:	MYLK2 / 85366	HGNCID:	16243	Length:	596	Species:	Homo sapiens

Alignment Length:	318	Identity:	70/318 - (22%)
Similarity:	136/318 - (42%)	Gaps:	54/318 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TLNINGSRYTIRERLATGG--FSLIDLGENASTRRSYAIKRITCHSIDDQNIALREIENCRKIDS 84
            |.|:: |.:::..:.|.||  |..:......:|....|.|.|...:..|:.:.|.|||...:::.
Human   276 TGNVS-SEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNH 339

  Fly    85 ENVIRVVDYELKGQADIVINTTSTLFIVLPYYKHGSLADHLQLRSRKQD-HMPEAQILQIFLGVC 148
            .|:|         |....|.|...:.:.:.|.:.|.|.:    |...:| |:.|...:.....:|
Human   340 RNLI---------QLYAAIETPHEIVLFMEYIEGGELFE----RIVDEDYHLTEVDTMVFVRQIC 391

  Fly   149 EGLKAIHEAMPVPLAHRDLKTANI-CLSDSFEPI-IVDLGSMTEARLQIVGQTDAQRLQDEAEER 211
            :|:..:|:   :.:.|.|||..|| |::.:...: |:|.|.             |:|.  ...|:
Human   392 DGILFMHK---MRVLHLDLKPENILCVNTTGHLVKIIDFGL-------------ARRY--NPNEK 438

  Fly   212 SSIVYRAPELFT--VKTYCTIDERTDIWSLGCVLYAMCYFNSPYDPIYERGDSVAL-AVLSGNIN 273
            ..:.:..||..:  |..|..|.::||:||:|.:.|.:.   |...|.....|:..| .|||||..
Human   439 LKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLL---SGLSPFLGDDDTETLNNVLSGNWY 500

  Fly   274 IPEDSI--YTEDMHELIKYMLRTDPMER---------PFVFSVIERTHDLIQKLEGRL 320
            ..|::.  .:::..:.:..::..|...|         |::.::.|:.....::|:.::
Human   501 FDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQI 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1227	NP_001287207.1	STKc_16	29..314	CDD:270888	66/303 (22%)
CG1227	NP_001287207.1	S_TKc	30..300	CDD:214567	64/288 (22%)
MYLK2	NP_149109.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..224
		STKc_MLCK2	280..540	CDD:271092	66/294 (22%)
		Calmodulin-binding. /evidence=ECO:0000250	574..586
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910