DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1227 and MARK4

DIOPT Version :9

Sequence 1:	NP_001287207.1	Gene:	CG1227 / 40872	FlyBaseID:	FBgn0037491	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_001186796.1	Gene:	MARK4 / 57787	HGNCID:	13538	Length:	752	Species:	Homo sapiens

Alignment Length:	296	Identity:	76/296 - (25%)
Similarity:	123/296 - (41%)	Gaps:	48/296 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RGCLFSCRKETLNINGSRYTIRERLATGGFSLIDLGENASTRRSYAIKRITCHSIDDQNI--ALR 74
            |..:.||.:|..::  ..|.:...:..|.|:.:.|..:..|.|..|||.|....::..::  ..|
Human    43 RNSIASCPEEQPHV--GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFR 105

  Fly    75 EIENCRKIDSENVIRVVDYELKGQADIVINTTSTLFIVLPYYKHGSLADHLQLRSRKQDHMPEAQ 139
            |:...:.::..|::::.:         ||.|..||::|:.|...|.:.|:|....|.::....|:
Human   106 EVRIMKGLNHPNIVKLFE---------VIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAK 161

  Fly   140 ILQIFLGVCEGLKAIHEAMPVPLAHRDLKTANICLSDSFEPIIVDLGSMTEARLQIVGQTDAQRL 204
            ..||       :.|:|......:.|||||..|:.|.......|.|.|...|..|       ..:|
Human   162 FRQI-------VSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTL-------GSKL 212

  Fly   205 QDEAEERSSIVYRAPELFTVKTYCTIDERTDIWSLGCVLYAMCYFNSPYD-----PIYERGDSVA 264
            ....   .|..|.|||||..|.|  .....||||||.:||.:...:.|:|     .:.||
Human   213 DTFC---GSPPYAAPELFQGKKY--DGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRER----- 267

  Fly   265 LAVLSGNINIPEDSIY-TEDMHELIKYMLRTDPMER 299
              ||.|...:|   .| :.|...:::..|..:|.:|
Human   268 --VLRGKYRVP---FYMSTDCESILRRFLVLNPAKR 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1227	NP_001287207.1	STKc_16	29..314	CDD:270888	72/279 (26%)
CG1227	NP_001287207.1	S_TKc	30..300	CDD:214567	72/278 (26%)
MARK4	NP_001186796.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		STKc_MARK	58..310	CDD:270974	72/279 (26%)
		S_TKc	59..310	CDD:214567	72/278 (26%)
		UBA_MARK3_4	328..370	CDD:270590
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..614
		MARK4_C	654..752	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910