DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1227 and NEK3

DIOPT Version :9

Sequence 1:	NP_001287207.1	Gene:	CG1227 / 40872	FlyBaseID:	FBgn0037491	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_002489.1	Gene:	NEK3 / 4752	HGNCID:	7746	Length:	506	Species:	Homo sapiens

Alignment Length:	294	Identity:	77/294 - (26%)
Similarity:	132/294 - (44%)	Gaps:	42/294 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 YTIRERLATGGFSLIDLGENASTRRSYAIKRITC-HSIDDQNIALREIENCRKIDSENVIRVVD- 92
            |.:...:..|.|....|.::.|:.:.:|:|.|.. .|..:...:.:|.....|:...|::...:
Human     4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKES 68

  Fly    93 YELKGQADIVINTTSTLFIVLPYYKHGSLADHLQLRSRKQDHMPEAQILQIFLGVCEGLKAIHEA 157
            :|.:|.          |:||:.|...|.|..  :::.:|....||..||..|..:|.|:..||:.
Human    69 FEAEGH----------LYIVMEYCDGGDLMQ--KIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121

  Fly   158 MPVPLAHRDLKTANICLSDSFEPIIVDLGSMTEARLQIVGQTDAQRLQDEAEERSSIV----YRA 218
            .   :.|||:|:.||.|:.:.:   |.||....|||          |.:......:.|    |..
Human   122 R---VLHRDIKSKNIFLTQNGK---VKLGDFGSARL----------LSNPMAFACTYVGTPYYVP 170

  Fly   219 PELFTVKTYCTIDERTDIWSLGCVLYAMCYFNSPYDPIYERGDSVALAVLSGNINIPEDSIYTED 283
            ||::....|   :.::|||||||:||.:|....|:..  ....::.|.|..|.|: |..|.|:.:
Human   171 PEIWENLPY---NNKSDIWSLGCILYELCTLKHPFQA--NSWKNLILKVCQGCIS-PLPSHYSYE 229

  Fly   284 MHELIKYMLRTDPMERPFVFSVIER--THDLIQK 315
            :..|:|.|.:.:|..||...:::.|  ...|:||
Human   230 LQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQK 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1227	NP_001287207.1	STKc_16	29..314	CDD:270888	75/291 (26%)
CG1227	NP_001287207.1	S_TKc	30..300	CDD:214567	71/275 (26%)
NEK3	NP_002489.1	Interaction with VAV2. /evidence=ECO:0000269\|PubMed:15618286	1..285		77/294 (26%)
		STKc_Nek3	3..257	CDD:173759	74/286 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..325
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910